Abstract:
:Mitochondria exert crucial physiological functions that create complex links among nutrition, health, and disease. While mitochondrial dysfunction with subsequent impairment of oxidative phosphorylation (OXPHOS) is the hallmark of the rare inherited OXPHOS diseases, OXPHOS dysfunction also plays a central role in the pathophysiology of common conditions such as type 2 diabetes and various neurodegenerative disorders. Dietary interventions, especially calorie restriction, have been shown to improve the course of these diseases and to extend the lifespan. Few data are available on the impact of nutraceuticals (macronutrients, vitamins, and cofactors) on primary inherited OXPHOS diseases. This review presents recent knowledge about the impact of nutritional modulation on mitochondria and lifespan regulation and about the development of potential treatments for mitochondrial dysfunction diseases.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Schiff M,Bénit P,Coulibaly A,Loublier S,El-Khoury R,Rustin Pdoi
10.1111/j.1753-4887.2010.00363.xsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
65-75issue
2eissn
0029-6643issn
1753-4887journal_volume
69pub_type
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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journal_title:Nutrition reviews
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pub_type: 杂志文章,评审
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