Mitochondrial response to controlled nutrition in health and disease.

Abstract:

:Mitochondria exert crucial physiological functions that create complex links among nutrition, health, and disease. While mitochondrial dysfunction with subsequent impairment of oxidative phosphorylation (OXPHOS) is the hallmark of the rare inherited OXPHOS diseases, OXPHOS dysfunction also plays a central role in the pathophysiology of common conditions such as type 2 diabetes and various neurodegenerative disorders. Dietary interventions, especially calorie restriction, have been shown to improve the course of these diseases and to extend the lifespan. Few data are available on the impact of nutraceuticals (macronutrients, vitamins, and cofactors) on primary inherited OXPHOS diseases. This review presents recent knowledge about the impact of nutritional modulation on mitochondria and lifespan regulation and about the development of potential treatments for mitochondrial dysfunction diseases.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Schiff M,Bénit P,Coulibaly A,Loublier S,El-Khoury R,Rustin P

doi

10.1111/j.1753-4887.2010.00363.x

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

65-75

issue

2

eissn

0029-6643

issn

1753-4887

journal_volume

69

pub_type

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