Discovery of the hemochromatosis gene will require rethinking the regulation of iron metabolism.

Abstract:

:The identity of the protein responsible for hemochromatosis, the iron overload disease, has eluded scientists for years. However, a recent report identifies the gene where the hemochromatosis defect lies. It is a gene that encodes a major histocompatibility complex (MHC) class-1-like protein called HLA-H. The mechanism by which an HLA-H defect alters iron metabolism is still unidentified. However, this new discovery will certainly ignite a new wave of study into the physiology of iron metabolism and its regulation.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Fleet JC

doi

10.1111/j.1753-4887.1996.tb03949.x

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

285-7

issue

9

eissn

0029-6643

issn

1753-4887

journal_volume

54

pub_type

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