Transcriptional switches in the control of macronutrient metabolism.

Abstract:

:This review shows how some transcription factors respond to alterations in macronutrients. Carbohydrates induce enzymes for their metabolism and fatty acid synthesis. Fatty acids reduce carbohydrate processing, induce enzymes for their metabolism, and increase both gluconeogenesis and storage of fat. Fat stores help control carbohydrate uptake by other cells. The following main transcription factors are discussed: carbohydrate response element-binding protein; sterol regulatory element-binding protein-1c, cyclic AMP response element-binding protein, peroxisome proliferator-activated receptor-alpha, and peroxisome proliferator-activated receptor-gamma.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Wise A

doi

10.1111/j.1753-4887.2008.00039.x

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

321-5

issue

6

eissn

0029-6643

issn

1753-4887

pii

NURE039

journal_volume

66

pub_type

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