Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations.

Abstract:

:Twenty publications from twelve prospective cohorts have evaluated associations between flavonoid intakes and incidence or mortality from cardiovascular disease (CVD) among adults in Europe and the United States. The most common outcome was coronary heart disease mortality, and four of eight cohort studies reported significant inverse associations for at least one flavonoid class (multivariate adjusted p(trend) < 0.05). Three of seven cohorts reported that greater flavonoid intake was associated with lower risk of incident stroke. Comparisons among the studies were difficult because of variability in the flavonoid classes included, demographic characteristics of the populations, outcomes assessed, and length of follow-up. The most commonly examined flavonoid classes were flavonols and flavones combined (11 studies). Only one study examined all seven flavonoid classes. The flavonol and flavone classes were most strongly associated with lower coronary heart disease mortality. Evidence for protection from other flavonoid classes and CVD outcomes was more limited. The hypothesis that flavonoid intakes are associated with lower CVD incidence and mortality requires further study.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Peterson JJ,Dwyer JT,Jacques PF,McCullough ML

doi

10.1111/j.1753-4887.2012.00508.x

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

491-508

issue

9

eissn

0029-6643

issn

1753-4887

journal_volume

70

pub_type

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