Abstract：
UNLABELLED:While the role of antiepileptic drug (AED) therapy in teratogenesis has widely been investigated, there are few prospective studies on later postnatal development in offspring of epileptic women in utero exposed. The aim of this study was a prospective investigation of the psychomotor development in a selected population of infant born to women with epilepsy on AED therapy during pregnancy. PATIENTS AND METHODS:Children were assessed at various times until 30 months of age by general movement (GMs) observation (at 7 days and 4 and 13 weeks), traditional neurologic examination (at 7 days and 4 and 13 weeks, 6, 9 and 12 months) and Brunet-Lezine (B-L) administration (at 30 months). We present the preliminary results of our study conducted on 11 children. RESULTS:Psychomotor delay in children was confirmed by traditional neurological examinations scores at 7 days, 4 weeks, 13 weeks and 6 months and by B-L score at 30 months. Between 9 and 12 months of age, traditional neurologic examination became "silent". GM assessment was found to be a better predictor of psychomotor development. In fact, GM analysis, particularly at 4 weeks, was strongly correlated with the Brunet-Lezine score at 30 months. In conclusion, on the basis of these data we suggest a psychomotor delay in the offspring of epileptic women and that GMs and neurologic evaluation provide complementary information concerning psychomotor development and later outcome of these children.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Parisi P,Francia A,Vanacore N,Fiore S,Giallonardo AT,Manfredi Mdoi
10.1016/s0378-3782(03)00083-5keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
97-108issue
2eissn
0378-3782issn
1872-6232pii
S0378378203000835journal_volume
74pub_type
杂志文章abstract：:A significant improvement has been achieved in perinatal mortality figures during the last decade in Japan with a neonatal mortality rate of 2.6 and a stillbirth rate of 4.1 for 1989. With its unique obstetric and neonatal services, there are advantages and also disadvantages in respect of clinical and basic research....
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90185-j
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journal_title：Early human development
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90132-z
更新日期：1992-06-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2017-10-01 00:00:00
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更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0378-3782(83)90028-2
更新日期：1983-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.06.001
更新日期：2008-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1992-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.07.015
更新日期：2012-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.01.002
更新日期：2010-01-01 00:00:00
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journal_title：Early human development
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doi：10.1016/0378-3782(85)90100-8
更新日期：1985-07-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-10-01 00:00:00
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更新日期：1989-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-04-01 00:00:00
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pub_type： 杂志文章,实务指引
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更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90113-6
更新日期：1985-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
