Abstract：
OBJECTIVE:A short course of moderately early dexamethasone therapy with a starting dose of 0.5 mg/kg/day improves lung compliance and shortens the duration of ventilatory support in preterm infants with respiratory distress syndrome (RDS). We conducted a double-blind, randomized study to evaluate whether a moderately early 14-day weaning course of low-dose dexamethasone affects adrenal function and facilitates weaning from the ventilator. PATIENTS AND METHODS:Thirty-six preterm infants with a gestational age < or =32 weeks who required ventilatory support for RDS on days 7-14 were randomized to a 14-day treatment course with dexamethasone (0.2 mg/kg/day start, tapering doses) or placebo (equivalent amounts of normal saline). Prior to the first study treatment and the day after completion of the treatment course, adrenal function was assessed from serum cortisol levels drawn before and 30 min after intravenous administration of 0.1 mg Cortrosyn. Extubation rate during treatment in both groups was compared. RESULTS:In both groups baseline serum cortisol levels decreased significantly during treatment, but stimulated cortisol levels did not change. After the 14-day treatment course, stimulated cortisol levels increased significantly from baseline levels in both groups (p<0.001), following Cortrosyn administration. More infants in the dexamethasone group were extubated within 7-14 days of study entry than in the placebo group (p<0.05). Hyperglycemia was more frequently diagnosed in the dexamethasone group and open-label dexamethasone treatment was given more frequently in the control group. CONCLUSIONS:A moderately early 14-day weaning course of low-dose dexamethasone does not significantly suppress the adrenal function of very preterm infants with RDS, but accelerates weaning from the ventilator.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Walther FJ,Findlay RD,Durand Mdoi
10.1016/s0378-3782(03)00082-3keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
37-45issue
1eissn
0378-3782issn
1872-6232pii
S0378378203000823journal_volume
74pub_type
临床试验,杂志文章,随机对照试验abstract：AIMS:Mastitis in lactating mothers reduces milk production and alters the cellular composition of milk. Changes occurring in the mammary gland during the inflammatory response are believed to increase the permeability of the blood-milk barrier. This study examined the effect of mastitis during lactation on the macronut...
journal_title：Early human development
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journal_title：Early human development
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doi：10.1016/j.earlhumdev.2013.03.013
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journal_title：Early human development
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abstract：:Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.10.008
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Early human development
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.02.005
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.08.009
更新日期：2013-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.01.002
更新日期：2012-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2006-05-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0378-3782(90)90137-8
更新日期：1990-08-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,实务指引
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1986-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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abstract：BACKGROUND:Hydatidiform mole is an abnormal pregnancy with over-proliferation of the placenta, which causes the dysfunction of placenta. Although more than 80% of hydatidiform moles are benign with good outcome, hydatidiform moles are associated with developing very early onset preeclampsia. However the association bet...
journal_title：Early human development
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss ...
journal_title：Early human development
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1993-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
abstract：:This century has seen marked improvement in perinatal outcomes but prematurity remains a problem the world over. To improve these results requires more attention to early pregnancy or even pre-pregnancy care. Control of pre-existing conditions, improved social behavior in nutrition, smoking cessation and other factors...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90064-n
更新日期：1992-06-01 00:00:00
