Abstract:
BACKGROUND:Hydatidiform mole is an abnormal pregnancy with over-proliferation of the placenta, which causes the dysfunction of placenta. Although more than 80% of hydatidiform moles are benign with good outcome, hydatidiform moles are associated with developing very early onset preeclampsia. However the association between hydatidiform mole and very early onset preeclampsia is unclear. Preeclampsia is associated with altered levels of angiogenic factors, like vascular endothelial growth factor (VEGF) and soluble endoglin. AIM:The aim of this study is to investigate the levels of VEGF and endoglin in hydatidiform molar placenta. STUDY DESIGN:21 placentas from complete hydatidiform mole, 9 placentas from partial hydatidiform mole and 18 placentas from gestation matched placenta were collected in this study. SUBJECTS:The subjects of this study are human placentas. OUTCOME MEASURES:The protein levels and mRNA levels of VEGF and endoglin were measured using immunohistochemistry, western blotting and real time PCR. RESULTS:The protein levels of VEGF measured by immunohistochemistry and western blotting were significant increased, as well as mRNA levels of VEGF quantified by real time PCR in hydatidiform molar placenta in comparison to normal controls. There was no difference in the protein levels of VEGF between complete and partial hydatidiform moles. In contrast, the levels of protein and mRNA in endoglin were no difference between hydatidiform molar placenta and normal controls. CONCLUSION:In this study our data show that hydatidiform moles produce more VEGF than normal early pregnant placenta. The increased levels of angiogenic factors VEGF in hydatidiform moles may link to the mechanism of developing very early onset preeclampsia.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Zhao M,Yin Y,Guo F,Wang J,Wang K,Chen Qdoi
10.1016/j.earlhumdev.2013.02.008subject
Has Abstractpub_date
2013-08-01 00:00:00pages
583-8issue
8eissn
0378-3782issn
1872-6232pii
S0378-3782(13)00038-8journal_volume
89pub_type
杂志文章abstract::Lenticulostriate vasculopathy (LSV) is a diagnosis dependent on neonatal cranial ultrasound (US). The diagnosis of LSV requires the presence of linear or branching echogenicities in the area of the basal ganglia and/or thalamus on gray scale cranial US. Although the diagnosis of LSV is dependent on cranial US, there a...
journal_title:Early human development
pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Maternal smoking during pregnancy is associated with short-term and also long-term harmful effects on offspring. OBJECTIVE:The aim of this study is to evaluate the associations of maternal smoking during pregnancy with offspring bone health at 18years old, and the role of birth weight and contemporaneous he...
journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
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journal_title:Early human development
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journal_title:Early human development
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
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journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Early human development
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journal_title:Early human development
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journal_title:Early human development
pub_type: 杂志文章,实务指引
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journal_title:Early human development
pub_type: 临床试验,杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90105-p
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00063-8
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.05.021
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.04.010
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journal_title:Early human development
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章,多中心研究
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.10.019
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00