Abstract:
:The Golgi-Cox method was used to study the maturation of the large pyramidal cells of the Vth cortical layer in three groups of adult rats: one subjected to undernutrition during the first month of life, another throughout the first 2 mth of life, and the last one during gestation and the suckling period. The main alterations consist of a decrease in the number and span of dendritic basilar processes of large pyramidal cells. In animals malnourished during prenatal life and the suckling period the reduction of the basal dendritic arborization was more apparent. It is postulated that the vulnerable period for the basal dendritic development occupies the period from the end of pregnancy until the first 3 wk of postnatal life in the rat (suckling period). Noxious influences acting during this phase induce sequelae that cannot be reversed by subsequent refeeding. A maintained nutritional insult during prenatal and early postnatal life induces the most severe changes in dendritic arborizations, compared to those resulting from a prolonged postnatal malnutrition.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Cordero ME,Trejo M,García E,Barros T,Rojas AM,Colombo Mdoi
10.1016/0378-3782(86)90186-6subject
Has Abstractpub_date
1986-12-01 00:00:00pages
245-58issue
3-4eissn
0378-3782issn
1872-6232pii
0378-3782(86)90186-6journal_volume
14pub_type
杂志文章abstract:OBJECTIVE:To compare paired antepartum fetal/maternal COHb ratios in whole blood from control and alloimmunized pregnancies and to examine the relationships between fetal and maternal COHb. METHODS:COHb levels were measured in paired fetal and maternal blood samples obtained at cordocentesis in 47 control and 16 Rh-al...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(00)00079-7
更新日期:2000-06-01 00:00:00
abstract::Nearly 10% of premature infants are born very preterm at 32weeks gestational age or less in the United States. Up to 35% of these very preterm survivors are at risk for cognitive and behavioral deficits. Yet accurate diagnosis of such deficits cannot be made until early childhood. Resting-state fMRI provides noninvasi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.06.002
更新日期:2016-07-01 00:00:00
abstract::We report a breast-fed preterm infant (31 weeks gestation) who developed nutritional zinc deficiency 13 weeks post delivery. Serial samples of his mothers breast milk from early lactation (2 weeks post delivery) contained very low zinc concentrations, although her serum zinc and sweat zinc concentrations were normal. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90062-3
更新日期:1985-01-01 00:00:00
abstract::Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct inte...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2010.01.008
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Neonatal sepsis has been associated with poor neurodevelopmental outcome, however the evidence regarding the exact mechanism of the inflammation to the developing neonatal brain are inconclusive. AIMS:To investigate association between cerebral oxygenation during neonatal sepsis and neurodevelopmental outco...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.07.008
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Children with major anatomical congenital anomalies (CA) often need prolonged hospitalization with surgical interventions in the neonatal period and thereafter. Better intensive care treatment has reduced mortality rates, but at the cost of more morbidity. AIM:To study motor-function and exercise capacity i...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.06.014
更新日期:2010-08-01 00:00:00
abstract::The magnitude of inflating pressure necessary for effective resuscitation was examined in 70 preterm infants. The median pressure to cause adequate chest wall expansion was 22.8 cmH2O; no infant required a peak inflating pressure greater than 30 cmH2O. No further increase in inflation pressure was used during resuscit...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90045-5
更新日期:1991-07-01 00:00:00
abstract:INTRODUCTION:In neonates with spina bifida aperta (SBA), leg movements by myotomes caudal to the meningomyelocele (MMC) are transiently observed. It is unclear whether these leg movements relate to functional neural conduction through the MMC. For optimal therapeutical intervention, pathophysiological insight in these ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.09.002
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Fluconazole prophylaxis has demonstrated efficacy in single and multicenter randomized controlled trials without side effects or emergence of resistance. Additional evidence based on incidence of invasive Candida infections, multicenter data, resistance, and safety is desired. METHODS:We conducted a case-co...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0378-3782(14)70026-X
更新日期:2014-03-01 00:00:00
abstract::Vascular tumours (haemangiomas and malformations) are common tumours of infancy and childhood. They represent a group of mostly benign conditions, which present early, can grow rapidly and be symptomatic or disfiguring. There are various management options, with different cosmetic and functional outcomes. Haemangiomas...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.08.017
更新日期:2010-10-01 00:00:00
abstract::COVID-19 remains pandemic. Social distancing and travel restrictions have avoided countless deaths and infections but disrupted livelihoods and economies. The global loss of gross (world) product is unprecedented as COVID-19 has inflicted both a supply-side and a demand-side shock. While public health measures have mi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105209
更新日期:2020-10-01 00:00:00
abstract::Low birthweight has been associated with diseases and disorders later in life. It has been suggested that this is caused by the impaired development of abdominal organs, especially in cases of growth retardation. Besides general malnutrition of the fetus, preferential bloodflow to the heart and brain may further depri...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(97)00073-x
更新日期:1998-04-17 00:00:00
abstract:BACKGROUND:Retinopathy of prematurity (ROP) is often associated with visual impairment and multiple developmental disabilities. AIMS:As most of the previous studies include infants with brain lesions, that can determine visual impairment per se, a cohort of low neurological risk preterm infants without ROP and with va...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105134
更新日期:2020-09-01 00:00:00
abstract::Measurement of methionine levels in dried blood spots has been one of the items of neonatal screening in Taiwan for more than 20 years. In 1,701,591 newborns, 17 cases of hypermethioninemia were detected, but among them only one had homocystinuria. More than half of the 16 cases of isolated hypermethioninemia had muta...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.11.005
更新日期:2005-06-01 00:00:00
abstract::The validity of the Wigglesworth experimental model to produce newborn rats that are small for gestational age by ligation of one of both uterine vessels was confirmed. Newborn rats from the opposite horns are used as controls in the classical model. It is concluded from this study that newborns from sham-operated dam...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(79)90038-0
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:Using pure oxygen (PO) in neonatal resuscitation increases oxidative stress and mortality in full-term hypoxic infants. International neonatal resuscitation guidelines recommend air or blended oxygen for resuscitation regardless of gestational age but this requires education and equipment that may not be glo...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.01.005
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To identify obstetric risk factors and to elucidate the effect of prolonged rupture of the membranes on the development of cystic periventricular leukomalacia (PVL) in preterm infants. METHODS:A retrospective case-control study of 95 preterm infants with the diagnosis of PVL and 245 healthy controls matched ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.07.007
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decrea...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.01.001
更新日期:2008-08-01 00:00:00
abstract::Candidal chorioamnionitis is an uncommon and apparently rather indolent intrauterine infection in which the fetus is able to marshal some of the immunological forces at its disposal against an easily visualized antigen impinging on lung mucosal surfaces. In a retrospective histological study of one of the largest repo...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90113-6
更新日期:1985-05-01 00:00:00
abstract::There is convincing evidence that breast-feeding is protective against gastro-enteritis and diarrhoea, but for other infections the situation is less clear cut. There is evidence that breast-fed infants are at increased risk of one infection (infant botulism). They are probably not significantly protected from upper r...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(97)00056-x
更新日期:1997-10-29 00:00:00
abstract::A new protocol for structured observation of motor performance in infants, SOMP-I, was applied to 72 neonatally healthy fullterm infants at 0, 2, 4, 6 and 10 months of age. It contains 13 items, formed as ascending scales, consisting of detailed descriptions of motor performance in different body positions and body pa...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(94)01598-J
更新日期:1995-01-30 00:00:00
abstract:BACKGROUND:Fetal cells exfoliate in the uterine cavity during early pregnancy and are a potential source of material for NIPD. AIMS:This study was designed to test the hypothesis that fetal cells obtained from the uterine cervix during the first trimester of pregnancy could be utilized for prenatal diagnosis of chromo...
journal_title:Early human development
pub_type: 临床试验,杂志文章
doi:10.1016/j.earlhumdev.2010.04.005
更新日期:2010-05-01 00:00:00
abstract::Near infrared spectroscopy (NIRS) monitoring is a new challenge for clinicians who deal with early detection of dangerous hypoperfusion in the brain, as well as in splanchnic and renal districts in critically ill preterm infants. Previous studies performed on infants and children with congenital heart disease, demonst...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(13)70014-8
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Acidemia at birth is very common but little is known about its long-term consequences. AIM:To determine if pH at birth is related to established tests of intellectual function. SUBJECTS:School children aged 6-8, for whom obstetric data were available, who had been delivered after labour at term, and had an...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2007.02.002
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of single and repeated courses of antenatal corticosteroids on brain growth in very preterm babies. DESIGN:Retrospective study of 110 very preterm babies delivered at a single University Teaching Hospital between 1992 and 1999 who had a full necropsy including detailed examination...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(01)00144-x
更新日期:2001-07-01 00:00:00
abstract:AIMS:Mastitis in lactating mothers reduces milk production and alters the cellular composition of milk. Changes occurring in the mammary gland during the inflammatory response are believed to increase the permeability of the blood-milk barrier. This study examined the effect of mastitis during lactation on the macronut...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.03.009
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Many preterm children show difficulties in attention at (pre)school age. The development of attention capacities of preterm and term toddlers was compared using a longitudinal and multi-method approach at 12, 18 and 24months. METHOD:Attention was measured for 123 preterm (32-36weeks gestation) and 101 term b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.08.015
更新日期:2015-12-01 00:00:00
abstract::According to animal studies myoinositol decreases surfactant phosphatidylglycerol and increases phosphatidylinositol. In the present study lung effluent phospholipids and serum myoinositol were analyzed in respiratory distress syndrome (RDS, 19 cases), in other lung disease (6 cases) and in 22 newborn with no lung dis...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90055-6
更新日期:1985-01-01 00:00:00
abstract::The anatomical findings of sirenomelia in a 12-weeks aborted embryo are reported. The occurrence of sirenomelia in material from spontaneous abortions is discussed. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(87)90080-6
更新日期:1987-07-01 00:00:00
abstract::Bilirubin-albumin binding was quantitated (peroxidase method) before, during, and after phototherapy in 21 jaundiced infants. Binding was analyzed at two different serum dilutions (1:1.8 and 1:57) to determine whether binding competitors are present during phototherapy. No significant changes in binding were found at ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90099-8
更新日期:1982-04-01 00:00:00