Abstract：
BACKGROUND:Fetal cells exfoliate in the uterine cavity during early pregnancy and are a potential source of material for NIPD. AIMS:This study was designed to test the hypothesis that fetal cells obtained from the uterine cervix during the first trimester of pregnancy could be utilized for prenatal diagnosis of chromosomal aneuploidy. STUDY DESIGN:Fetal cells retrieved from the distal endocervical canal during the first trimester of pregnancy were hybridized with chromosome 21 specific FISH probes and analyzed with an automated fluorescence microscope. SUBJECTS AND OUTCOME MEASURES:Cells with 3 copies of chromosome 21 were detected in 5 out of 5 trisomy 21 pregnancies. RESULTS:The number of trisomic cells detected ranged from 1 to 27 with a median value of 5. CONCLUSIONS:FISH-based scanning can identify trisomy 21 pregnancies by analysis of routine cervical brushings. The approach offers the potential for non-invasive prenatal diagnosis as early as 5 weeks gestation.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Sifakis S,Ghatpande S,Seppo A,Kilpatrick MW,Tafas T,Tsipouras P,Fejgin M,Amiel Adoi
10.1016/j.earlhumdev.2010.04.005subject
Has Abstractpub_date
2010-05-01 00:00:00pages
311-3issue
5eissn
0378-3782issn
1872-6232pii
S0378-3782(10)00088-5journal_volume
86pub_type
临床试验,杂志文章abstract：BACKGROUND:Maternal smoking during pregnancy is associated with short-term and also long-term harmful effects on offspring. OBJECTIVE:The aim of this study is to evaluate the associations of maternal smoking during pregnancy with offspring bone health at 18years old, and the role of birth weight and contemporaneous he...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.08.024
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:In the general framework of relating birthing events to later mental development, this study addresses the hypothesis that uneventful non-vertex delivery is associated with higher intelligence than uneventful vertex delivery. STUDY DESIGN:In the course of a developmental obstetrical survey, data was gathered...
journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.01.002
更新日期：2016-03-01 00:00:00
abstract：AIMS:To study longitudinal growth pattern of head circumference of full-term symmetric and asymmetric small for gestational age (SGA) infants of the two sexes during first year of life. STUDY DESIGN:Mixed-longitudinal growth research design. SUBJECTS:Head circumference amongst full-term 100 symmetric, 100 asymmetric ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.11.007
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abstract：:Near infrared spectroscopy (NIRS) monitoring is a new challenge for clinicians who deal with early detection of dangerous hypoperfusion in the brain, as well as in splanchnic and renal districts in critically ill preterm infants. Previous studies performed on infants and children with congenital heart disease, demonst...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(13)70014-8
更新日期：2013-06-01 00:00:00
abstract：:Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.10.008
更新日期：2012-06-01 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
abstract：:Maturation of spontaneous fetal body and breathing movements of 24- to 33-week-old fetuses in 168 pregnancies threatening to deliver prematurely were examined on the basis of newborn outcome (premature compromised, premature healthy, term healthy). Maturation of fetuses in 60 low-risk pregnancies delivering as healthy...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00007-9
更新日期：1999-05-01 00:00:00
abstract：:This study documents the longitudinal development of head control in 104 infants born at 25-33 weeks gestation. Protective side turning of the head was found to have a developmental sequence of reducing spinal extension. In the 93 infants with normal motor outcome, individual differences in the rate of development cor...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90074-x
更新日期：1985-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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abstract：:It is becoming increasingly apparent that pyridoxine responsive homocystinuria patients are being missed by newborn screening programs. The possibility that screening for homocystine, rather than the methionine, might be more effective was investigated by comparing homocystine and methionine levels of non-responsive p...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(96)01860-9
更新日期：1997-04-25 00:00:00
abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are prescribed in 2-8% during pregnancy. Whether prenatal exposure to SSRIs has long-term effects on the children's development is unknown. AIM:The aim of this study was to determine the effect of prenatal exposure to SSRIs on children's cognitive, motor, and ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105075
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Fluconazole prophylaxis has demonstrated efficacy in single and multicenter randomized controlled trials without side effects or emergence of resistance. Additional evidence based on incidence of invasive Candida infections, multicenter data, resistance, and safety is desired. METHODS:We conducted a case-co...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0378-3782(14)70026-X
更新日期：2014-03-01 00:00:00
abstract：:The purpose of this study was to investigate prostanoid synthesis in different segments of the umbilicoplacental vascular tree and its relationship to impaired maternal glucose tolerance. Segments from the umbilical artery and vein, allantochorionic artery branches, and the cotyledon artery from 21 women with diabetes...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3732(97)00036-2
更新日期：1998-01-09 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.07.004
更新日期：2005-03-01 00:00:00
abstract：:There is a wide differential diagnosis of early onset respiratory distress especially in term babies, and interstitial lung disease (chILD) is a rare but important consideration in this context. chILD manifesting immediately after birth is usually related to mutations in surfactant protein genes, or conditions related...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105186
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Higher parenting stress in mothers of children born very preterm may be in part a response to poorer neurobehavioral development, reflecting realistic concerns in addition to adaptation to the trauma of preterm delivery. To our knowledge, there are few longitudinal studies of parenting stress that have addre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.01.030
更新日期：2011-04-01 00:00:00
abstract：:ELISA methods were used to determine the concentrations of CAI and CAII in spermatozoa, seminal plasma, ovarian follicular fluid, decidual tissues, chorionic villi and various fetal tissues at 8-11 weeks gestation. Both CAI and CAII were expressed in all subjects except ovarian follicular fluid samples. The possible p...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00119-9
更新日期：1998-07-10 00:00:00
abstract：:Delayed emergence of movement patterns and disturbances in the development of behavioural states are often observed in the fetuses of diabetic women. The developmental course of specific fetal movement patterns was studied in 20 women with type-1 diabetes during the first trimester of pregnancy. The aim was to investi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90190-e
更新日期：1991-05-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.03.010
更新日期：2016-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
abstract：:In this study of 167 neonates who demonstrated a total of 1010 transitions between arousal states, we considered whether specific state transitions were associated with umbilical cord blood lead levels. We found that the arousal patterns of neonates with varying levels (<1, 1-10 and >10 microg/dL) of lead exposure cou...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.06.002
更新日期：2008-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.11.007
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS:Eighty-one preterm infants b...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:The world's literature has been scoured to obtain data on 492 examples of the fetal alcohol syndrome (FAS) in the Northern Hemisphere. The seasonally pattern of FAS birth prevalence rates is compared with the seasonality pattern of ethanol intakes to estimate the time-lag between them and hence the timing of ethanol d...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90065-8
更新日期：1983-07-01 00:00:00
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journal_title：Early human development
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2012-02-01 00:00:00
abstract：:No statistically significant relationships were observed between the red blood cell acid phosphatase polymorphism (ACP-1) and birth weight, duration of gestation and proportion of preterm infants in a large series of newborn infants (greater than 8000) in Cardiff. These results are contrasted with those of a similar, ...
journal_title：Early human development
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.08.017
更新日期：2003-12-01 00:00:00
abstract：:Doctors are frequently depicted as important protagonists in science fiction, including in the science fiction franchise Star Trek. This paper will profile Drs. Philip Boyce and Mark Piper from the first two Star Trek pilot episodes. These doctors are interdisciplinarians with a variety of skills that permit them to c...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2020.104988
更新日期：2020-05-01 00:00:00
abstract：:In the scholarly environment, research findings are disseminated as journal papers which support/dispute extant knowledge or add further to what is already known. The entire manuscript needs to be cited (in-text) and referenced (at the end of article), in order for readers to ascertain the validity of the research cla...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.09.012
更新日期：2019-01-01 00:00:00
