Abstract：
BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated phosphoprotein 43 (GAP43) is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Therefore, the characteristics of GAP43-positive elements and their association with serotonergic neurons were here investigated in the brainstem of SIDS victims. MATERIALS AND METHODS:The materials of this study included 26 cases of SIDS and 12 control cases. The brainstem material was collected and the immunohistochemistry of GAP43 and tryptophan hydroxylase (TrypH) carried out. The density of GAP43-positive neurons and dendrites and of TrypH-positive neurons were measured quantitatively. Nonparametric analyses of GAP43 between SIDS and non-SIDS and correlation analyses between GAP43 and TrypH were performed. RESULTS:No significant difference in GAP43-associated findings was found between SIDS and non-SIDS nor any significant correlation between GAP43-associated findings and TrypH-positive neurons. CONCLUSIONS:The results of this study were not in agreement with the association of GAP43 with SIDS and with serotonergic innervation in SIDS.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Sawaguchi T,Patricia F,Kadhim H,Groswasser J,Sottiaux M,Nishida H,Kahn Adoi
10.1016/j.earlhumdev.2003.08.017keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
S139-46eissn
0378-3782issn
1872-6232pii
S0378378203001269journal_volume
75 Supplpub_type
杂志文章abstract：OBJECTIVE:To determine whether placental lesions are risk factors for neurologic morbidities in intrauterine growth restricted (IUGR) infants, we compared the incidence of cranial ultrasound (CUS) abnormalities and the number and type of placental lesions in IUGR cases and gestational age-matched appropriate for gestat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(01)00114-1
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Evaluation of cerebellar morphology and measurement of its biometric parameters such as cerebellar vermis height and transverse cerebellar diameter may assist the neonatologist in monitoring cerebellar growth and development and detect abnormalities resulting from malformations, hemorrhage or ischemic infarc...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.10.001
更新日期：2013-12-01 00:00:00
abstract：:The brain glycoconjugates, glycosidases and lipids have been studied in a case of human congenital athyroidism never treated with hormonal replacement. Increase of membrane-bound mucopolysaccharides has been found in the grey matter. Total lipids in the white matter, and phospholipids, and total glycolipids and choles...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90009-9
更新日期：1983-10-01 00:00:00
abstract：BACKGROUND:There is concern that exposure of preterm infants to noxious insults over a prolonged period may have long term effects on their developing nervous system. AIMS:To investigate medium and long term effects of heel pricks in infants over the first year of life. STUDY DESIGN:Study 1-a longitudinal study, 2 da...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.09.018
更新日期：2008-06-01 00:00:00
abstract：:Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life. Gastro-oesophageal reflux may be a primary gastro-intestinal motility disorder, but it may also be secondary to other conditions such as cow's milk protein allergy. Objective diagnosis can be ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.10.011
更新日期：2005-12-01 00:00:00
abstract：:A proportion of symptomatic neonates with congenital heart disease have lesions requiring urgent stabilisation. Despite increasing antenatal diagnoses, the importance of early recognition of symptomatic neonates is highlighted by the fact that up to 10% of all deaths in congenital heart disease continue to occur in ch...
journal_title：Early human development
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.earlhumdev.2008.01.011
更新日期：2008-03-01 00:00:00
abstract：:Interest in determining the quality of life of children and adults is now considered a priority. This is a result of a shift in thinking with greater transparency in finding out not only the health outcomes, but also the personal burden of illness and life satisfaction for the individual. However, there is still no co...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.01.012
更新日期：2013-04-01 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
abstract：:Interfacility transport is a necessary part of hospital care. Neonates often need to access specialist input at different sites necessitating a reliable transfer process. Services have evolved significantly over the last ten years to meet this need. This followed the recognition that ad hoc arrangements were unreliabl...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The importance of an infant's intra-oral vacuum in milk removal from the breast has been established. However, the relationship between the vacuum curve and milk transfer is not well understood. AIMS:To investigate the parameters of the infant suck cycle in relation to the volume of milk removed from the br...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.02.003
更新日期：2016-05-01 00:00:00
abstract：:Urinary epidermal growth factor (EGF) excretion was studied serially in 36 newborn infants, from 26 to 40 weeks gestation, from birth to three months of age. All infants excreted EGF from birth. Excretion was significantly higher in term infants than in preterm infants at birth; in term infants excretion rose steadily...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90190-8
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:Acidemia at birth is very common but little is known about its long-term consequences. AIM:To determine if pH at birth is related to established tests of intellectual function. SUBJECTS:School children aged 6-8, for whom obstetric data were available, who had been delivered after labour at term, and had an...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.02.002
更新日期：2008-01-01 00:00:00
abstract：:We describe the managment of 2 sets of pre-term quadruplets born to 2 women pregnant concurrently following the induction of ovulation with gonadotrophin. Careful antenatal planning was necessary to provide for each of the 8 pre-term infants a standard of neonatal medical and nursing care comparable to that normally a...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(77)90028-7
更新日期：1977-10-01 00:00:00
abstract：:Blood flow velocity was measured in both main stem uterine arteries by means of a transvaginally inserted Duplex scanner (240 degrees sector, pulsed Doppler) and visual vessel recognition to investigate normal and abnormal uterine perfusion. Its relationship to fetal circulation and fetal outcome was studied. Fetal ve...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90115-j
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis....
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.09.010
更新日期：2006-04-01 00:00:00
abstract：INTRODUCTION:COVID-19 is pandemic. International travel bans in March 2020 dampened viral spread and resulted in an overnight global economic crisis. As countries ease travel and social distancing restrictions, viral resurgences are expected. This study was carried out in order to delineate the development of a second ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105211
更新日期：2020-10-03 00:00:00
abstract：:Twenty-eight very low birth weight (VLBW) and 32 full term infants were prospectively assessed at one year of age for hearing, language development and neurological status. The prevalence of conductive hearing deficits was the same in both groups. Language scores in VLBW infants were significantly lower than in fullte...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90007-6
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:Neonatal Encephalopathy (NE) is a prominent cause of infant mortality and neurodevelopmental disability. Hypothermia is an effective neuroprotective therapy for newborns with encephalopathy. Post-hypothermia functional-anatomical correlation between neonatal neurobehavioral abnormalities and brain injury fin...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.05.006
更新日期：2013-09-01 00:00:00
abstract：UNLABELLED:During the previous two decades smoking among pregnant women in the developed world declined by about 60-75%. Nevertheless, prenatal smoking remains a common habit and accounts for a significant proportion of fetal morbidity and mortality through both a direct (fetal) and an indirect (placental) effect. The ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2007.08.002
更新日期：2007-11-01 00:00:00
abstract：:This study examined the oral sensitivity and feeding skills of low-risk pre-term infants at 11-17 months corrected age. Twenty pre-term infants (PT) born between 32 and 37 weeks at birth without any medical comorbidities were assessed. All of this PT group received supplemental nasogastric (NG) tube feeds during their...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.10.001
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Postural control differs between infants born preterm and full term at 1-3weeks of age. It is unclear if differences persist or alter the development of early behaviors. The aim of this longitudinal study was to compare changes in postural control variability during development of head control and r...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.01.006
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decrea...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.01.001
更新日期：2008-08-01 00:00:00
abstract：:The relative role of perinatal factors (birthweight, gestational age, gender, asphyxia, mechanical ventilation and cerebral lesions), developmental factors (neuromotor development during the first 18 months of life) and environmental factors (socio-economic status and bilingualism) on cognitive abilities was evaluated...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01673-2
更新日期：1995-10-02 00:00:00
abstract：OBJECTIVE:To compare paired antepartum fetal/maternal COHb ratios in whole blood from control and alloimmunized pregnancies and to examine the relationships between fetal and maternal COHb. METHODS:COHb levels were measured in paired fetal and maternal blood samples obtained at cordocentesis in 47 control and 16 Rh-al...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00079-7
更新日期：2000-06-01 00:00:00
abstract：AIM:To determine whether maternal state and trait anxiety levels affect fetal movements or fetal heart rate (FHR) in the third trimester. SUBJECTS:Forty-one healthy pregnant nulliparous women not on medication and with a singleton pregnancy. STUDY DESIGN:Maternal anxiety was assessed using the Spielberger State- Trai...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(01)00256-0
更新日期：2002-04-01 00:00:00
abstract：:Adrenocortical response to stress in neonates was assessed by estimating salivary concentrations of cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S). Behavioral responses to stress were also scored clinically, according to the method of Lewis and Thomas [15]. The modulation of these ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(96)01749-5
更新日期：1996-09-20 00:00:00
abstract：:Low nephron endowment secondary to intrauterine growth restriction (IUGR) results in compensatory hypertrophy of the remaining glomeruli, which in turn is associated with hypertension. However, gender differences exist in the response of the kidney to injury, and IUGR female offspring seems protected from an unfavorab...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.12.015
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:To assess the influence of mother-child interaction on children's cognitive development in a group of children prenatally exposed to methadone or buprenorphine. STUDY DESIGN:The study is part of a prospective longitudinal project investigating the development of children born to women in opioid maintenance t...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.08.013
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:We evaluated the effect of maternal administration of betamethasone (0.2 mg/kg per day) on mitogen-induced lymphocyte proliferation and interleukin-2 (IL-2) production by maternal, fetal, and neonatal rat splenic lymphocytes. STUDY DESIGN:Betamethasone was injected intramuscularly on days 19 and 20 of gestat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90028-0
更新日期：1994-01-01 00:00:00
abstract：:Altogether 2159 pregnancies among black and white Americans in the Collaborative Perinatal Study and dental casts from the children at the age of 5-12 years were studied to find out the effect of maternal smoking on deciduous tooth crown growth. Minor crown size reduction (2-3%) in some dimensions was found in childre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90086-v
更新日期：1992-08-01 00:00:00
