Abstract：
:The purpose of this study was to investigate prostanoid synthesis in different segments of the umbilicoplacental vascular tree and its relationship to impaired maternal glucose tolerance. Segments from the umbilical artery and vein, allantochorionic artery branches, and the cotyledon artery from 21 women with diabetes or impaired glucose tolerance and 10 healthy women were studied. Production of prostacyclin (PGI2) and thromboxane (TxA2) metabolites was determined. The Mann-Whitney U test, Wilcoxon signed-ranks matched-pairs test, Kruskal-Wallis test, analysis of variance, and simple linear regression analysis were used. A two-tailed P value of < 0.05 was considered statistically significant. From the umbilical artery distal to the cotyledon artery, the PGI2 synthesis decreased and the TxA2 synthesis increased gradually towards the periphery in normal pregnancy. The PGI2/TxA2 ratio was more than 200 times higher in the umbilical artery than in the cotyledon artery. The TxA2 production tended in general to be higher in the diabetic group than in the control group, resulting in significantly lower PGI2/TxA2 ratios in some vessels. The prostanoid production was not significantly correlated to maternal HbA1c or cord C-peptide concentrations. The balance between vascular prostacyclin and thromboxane synthesis in the umbilicoplacental arterial tree changed gradually towards the periphery: the more peripheral, the lower the prostacyclin and the higher the thromboxane production. The physiological role of this phenomenon is unknown, but may be of importance for the equilibration of vascular tone between arteries of different calibers. The altered prostanoid balance found in diabetic pregnancy was not directly attributable to the degree of maternal glycemic control, but may reflect increased free radical activity and peroxide production in diabetes.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Saldeen P,Olofsson P,Parhar RS,al-Sedairy Sdoi
10.1016/s0378-3732(97)00036-2subject
Has Abstractpub_date
1998-01-09 00:00:00pages
175-83issue
2eissn
0378-3782issn
1872-6232pii
S0378-3732(97)00036-2journal_volume
50pub_type
杂志文章abstract：:Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(13)70005-7
更新日期：2013-06-01 00:00:00
abstract：:221 small-for-dates (SFD) and 244 average-for-dates (AFD) children were personally examined at birth, and seen thereafter at regular intervals up to 4 years, when a thorough assessment was made. There was an excess of SFD children with major congenital abnormalities; but no difference between the groups in the number ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90007-5
更新日期：1983-10-01 00:00:00
abstract：:Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct inte...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2010.01.008
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Early iron supplementation in women with sufficient reserves could provoke iron excess resulting in haemoconcentration and low infant birth weight (IBW). AIM:To clarify the influence of early iron supplementation on maternal iron status and the IBW, taking into account pre-pregnancy iron deposits. STUDY DE...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.06.003
更新日期：2011-12-01 00:00:00
abstract：:The modern successes of reproductive medicine are based on the achievements in the fields of artificial fertilization and cryobiology over the last 50years. Cryopreservation of oocytes makes it possible to preserve their reproductive potential after surgical interventions, treatment of cancer, for delayed pregnancy an...
journal_title：Early human development
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.earlhumdev.2018.08.016
更新日期：2018-11-01 00:00:00
abstract：:The effect of type-I diabetes on the quality of general movements (GMs) was studied longitudinally in 12 human fetuses. GMs were analysed at two-weekly intervals from 16 weeks until delivery. A pregnancy optimality-score and a diabetes optimality-score were used to cover the course of the pregnancy and delivery and th...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00089-3
更新日期：1997-11-24 00:00:00
abstract：:To precisely measure the events of the fetal breath cycle it is necessary to have an accurate hard copy record. Two approaches to this have been made using either M-mode or Doppler ultrasound. It was the aim of this paper to compare these methods. Hard copy records of fetal breathing movements were produced by simulta...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90010-8
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Recent evidence suggests that cord insertion type of one twin correlates with chorionic plate vascularization of the monochorionic co-twin. Specifically, for twins with paracentral cords, chorionic plate vascularization is significantly greater when the co-twin has a velamentous, rather than paracentral cord...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.01.009
更新日期：2013-04-01 00:00:00
abstract：:There is increasing evidence that sleep plays a major role in the development of neural pathways in the neonatal brain. Several studies have suggested evidence-based approaches to improve sleep for infants admitted to the neonatal intensive care unit (NICU); however, in many neonatal centers very few of these strategi...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:Nurses worldwide have striven to establish nursing as a profession, autonomous but complementary to the medical profession. Literature as far back as the Renaissance demonstrates an overall derogatory attitude toward the nurse's role. The modern notion of the nurse working side by side the medical practitioner continu...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2020.105015
更新日期：2020-06-01 00:00:00
abstract：:Meconium aspiration syndrome (MAS) is a common neonatal problem and, sadly, results in acute and chronic respiratory morbidity. Although meconium aspiration can occur prior to delivery even in the absence of labour, in many infants this condition could be prevented by appropriate suctioning at birth. More accurate pre...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(95)01625-d
更新日期：1995-04-28 00:00:00
abstract：BACKGROUND:Children with major anatomical congenital anomalies (CA) often need prolonged hospitalization with surgical interventions in the neonatal period and thereafter. Better intensive care treatment has reduced mortality rates, but at the cost of more morbidity. AIM:To study motor-function and exercise capacity i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.06.014
更新日期：2010-08-01 00:00:00
abstract：:Twenty-eight very low birth weight (VLBW) and 32 full term infants were prospectively assessed at one year of age for hearing, language development and neurological status. The prevalence of conductive hearing deficits was the same in both groups. Language scores in VLBW infants were significantly lower than in fullte...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90007-6
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:Gastroschisis and omphalocele are the most common anterior abdominal wall defects affecting infants. There are few large cohort studies describing the frequency of associated anomalies in infants with these 2 conditions. We describe associated anomalies and outcomes in infants with these defects using a larg...
journal_title：Early human development
pub_type： 杂志文章,多中心研究
doi：10.1016/j.earlhumdev.2014.05.006
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Previous studies using ultrasound technology showed that fetal heart rate (HR) may be responsive to maternal aerobic exercise. Although it is recognized that cardiac autonomic control may be influenced by the intrauterine environment, little is known about how maternal exercise affects fetal heart developmen...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.03.002
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Respiratory syncytial virus (RSV) is a leading cause of hospitalization for children <1year old and is more severe in premature infants. OBJECTIVE:To assess whether late preterm (LPT) birth is an independent risk factor for RSV hospitalization and more severe RSV disease in children less than 24months old. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.06.009
更新日期：2015-09-01 00:00:00
abstract：:Spectral analysis was performed on ventilation and instantaneous heart rate data recorded in 15 term infants during quiet sleep in the first week after delivery, and in 11 of these infants during active sleep. There was a close relation between the main peaks of the ventilation spectra and the corresponding histograms...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90050-9
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:A short course of moderately early dexamethasone therapy with a starting dose of 0.5 mg/kg/day improves lung compliance and shortens the duration of ventilatory support in preterm infants with respiratory distress syndrome (RDS). We conducted a double-blind, randomized study to evaluate whether a moderately e...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-3782(03)00082-3
更新日期：2003-10-01 00:00:00
abstract：:Intra-uterine growth restriction (IUGR) is a severe and quite common problem in obstetrics. A condition of placental dysfunction can lead to a cardiovascular adaptation in the fetus characterized by a redistribution of cardiac output to maintain oxygen supply to the heart, adrenal glands and brain - the so-called brai...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.07.006
更新日期：2013-10-01 00:00:00
abstract：AIMS:1. To determine the survival and morbidity of infants at discharge with a birthweight of less than 1500 g in the geographically defined population of East Anglia. 2. To demonstrate a cost-effective method of regional data collection. 3. To determine whether there were any changes in the demand for neonatal care. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.10.019
更新日期：2006-02-01 00:00:00
abstract：:The relative role of perinatal factors (birthweight, gestational age, gender, asphyxia, mechanical ventilation and cerebral lesions), developmental factors (neuromotor development during the first 18 months of life) and environmental factors (socio-economic status and bilingualism) on cognitive abilities was evaluated...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01673-2
更新日期：1995-10-02 00:00:00
abstract：:Behavioural state observations were carried out on 12 fetuses which subsequently had birthweights below the 10th percentile. Their gestational ages at the time of study ranged from 32 to 40 weeks. Real-time ultrasound scanning was used to detect fetal body and eye movements, and the fetal heart rate was continuously r...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90181-1
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND:Evaluation of cerebellar morphology and measurement of its biometric parameters such as cerebellar vermis height and transverse cerebellar diameter may assist the neonatologist in monitoring cerebellar growth and development and detect abnormalities resulting from malformations, hemorrhage or ischemic infarc...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.10.001
更新日期：2013-12-01 00:00:00
abstract：:The introduction of exchange transfusion made it possible to prevent severe hyperbilirubinemia and kernicterus, but kernicterus has never completely disappeared and it is still occurring in North America and, more frequently in Western Europe and the developing world. I discuss the epidemiology and major causes of sev...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2009.09.003
更新日期：2009-11-01 00:00:00
abstract：:Whenever possible, oral feeding is the preferred method in neonatal feeding. However, many premature infants are unable to suck and swallow effectively; in these cases alternative methods of nutrient delivery must be used. We briefly review the different feeding methods used in neonatal units, with particular attentio...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(12)70011-7
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:In the general framework of relating birthing events to later mental development, this study addresses the hypothesis that uneventful non-vertex delivery is associated with higher intelligence than uneventful vertex delivery. STUDY DESIGN:In the course of a developmental obstetrical survey, data was gathered...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90065-5
更新日期：1994-09-30 00:00:00
abstract：:A comparison has been made of protein accretion and growth in premature infants fed banked drip breast milk (BBM) or a preterm formula (PF). Protein accretion was calculated from the difference between dietary nitrogen intake and output in urine and stools, measured in a nutrient balance study. As expected, only the i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90152-5
更新日期：1985-12-01 00:00:00
abstract：OBJECTIVE:Many preterm children show difficulties in attention at (pre)school age. The development of attention capacities of preterm and term toddlers was compared using a longitudinal and multi-method approach at 12, 18 and 24months. METHOD:Attention was measured for 123 preterm (32-36weeks gestation) and 101 term b...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.08.015
更新日期：2015-12-01 00:00:00
abstract：:Lung surfactant was obtained by postmortem lavage from: (A) premature babies: 34 dying acutely within 2 days of birth from Hyaline Membrane Disease (HMD), 20 dying several days after birth with HMD and its consequences, 8 dying from causes other than HMD; (B) mature babies: 24 dying stillborn, 15 dying soon after birt...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(88)90094-1
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND:The requirement of essential fatty acids (EFA) for the development of the brain is well documented. OBJECTIVE:To investigate the early neurological development at term and 44 weeks gestational age in preterm infants in relation to EFA concentrations in breast milk and in infants' and mothers' plasma phospho...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.05.017
更新日期：2010-07-01 00:00:00
