Neonatal apnea and gastroesophageal reflux (GER): is there a problem?

Abstract:

:Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is a temporal relationship apnea may be more likely to predispose to GER via esophageal sphincter relaxation than vice versa. Measurement of multiple intraluminal impedance via esophageal catheter in addition to esophageal pH has enhanced our understanding of GER, although it also did not demonstrate a causal relationship between apnea and GER. The incidence of GER may be modified by thickening feeds and position change without adverse effects. In contrast, pharmacotherapy including acid suppression therapy may have adverse effects and should only be used in infants with clear evidence of clinical benefit.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Abu Jawdeh EG,Martin RJ

doi

10.1016/S0378-3782(13)70005-7

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

S14-6

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(13)70005-7

journal_volume

89 Suppl 1

pub_type

杂志文章,评审
  • Thrombopoietin (Tpo) in the fetus and neonate: Tpo concentrations in preterm and term neonates, and organ distribution of Tpo and its receptor (c-mpl) during human fetal development.

    abstract::Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/s0378-3782(98)00077-2

    authors: Sola MC,Juul SE,Meng YG,Garg S,Sims P,Calhoun DA,Dame JB,Christensen D

    更新日期:1999-01-01 00:00:00

  • Retinol-binding protein and prealbumin in cord blood of term and preterm infants.

    abstract::Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(83)90068-3

    authors: Bhatia J,Ziegler EE

    更新日期:1983-07-01 00:00:00

  • Transthyretin levels are not related to Apgar score in low birth weight and very low birth weight infants.

    abstract:BACKGROUND:Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decrea...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2008.01.001

    authors: Su PH,Wang SL,Chen JY,Hu JM,Chang HP,Chen SJ

    更新日期:2008-08-01 00:00:00

  • Two-year neonatal outcome following PPROM prior to 25 weeks with a prolonged period of oligohydramnios.

    abstract:BACKGROUND:Improved neonatal survival data have been reported following early preterm prelabour rupture of membranes (PPROM) prior to 25 weeks gestation with a prolonged latency to delivery and persistent oligohydramnios. However, data regarding long-term respiratory and neurological morbidity are lacking. AIMS:To eva...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2012.01.012

    authors: Williams O,Michel B,Hutchings G,Debauche C,Hubinont C

    更新日期:2012-08-01 00:00:00

  • The contributions of fetal growth restriction and gestational age to developmental outcomes at 12 months of age: A cohort study.

    abstract:BACKGROUND:Preterm birth is a known risk factor for infant development but it is less clear whether fetal growth restriction (FGR) and early term birth between 37 and 39 weeks gestation are associated with risks for infant development. AIMS:This study investigated risk factors for adverse developmental outcomes at 12 ...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2020.104951

    authors: Baumgartel K,Jensen L,White SW,Wong K,Straker L,Leonard H,Finlay-Jones A,Downs J

    更新日期:2020-03-01 00:00:00

  • Fetal growth retardation as a cause of impaired ovarian development.

    abstract::Low birthweight has been associated with diseases and disorders later in life. It has been suggested that this is caused by the impaired development of abdominal organs, especially in cases of growth retardation. Besides general malnutrition of the fetus, preferential bloodflow to the heart and brain may further depri...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/s0378-3782(97)00073-x

    authors: de Bruin JP,Dorland M,Bruinse HW,Spliet W,Nikkels PG,Te Velde ER

    更新日期:1998-04-17 00:00:00

  • Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants.

    abstract:BACKGROUND:Term equivalent age (TEA) brain MRI identifies preterm infants at risk for adverse neurodevelopmental outcomes. But some infants may experience neurodevelopmental impairments even in the absence of neuroimaging abnormalities. OBJECTIVE:Evaluate the association of TEA amplitude-integrated EEG (aEEG) measures...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2018.02.010

    authors: El Ters NM,Vesoulis ZA,Liao SM,Smyser CD,Mathur AM

    更新日期:2018-04-01 00:00:00

  • The effects of maternal stress and child language ability on behavioral outcomes of children with congenital hearing loss at 18-24months.

    abstract:BACKGROUND:Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss ...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2011.06.006

    authors: Topol D,Girard N,St Pierre L,Tucker R,Vohr B

    更新日期:2011-12-01 00:00:00

  • A study on neonatal behaviour comparing between two groups from different cultural backgrounds.

    abstract::Fifty-one British newborn infants and 51 Japanese newborn infants were compared using Prechtl's neonatal neurological examination and Brazelton's neonatal behavioural assessment scale on the 5th day after birth. Statistically significant differences were found between the two groups. British infants were more responsi...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(92)90172-d

    authors: Eishima K

    更新日期:1992-03-01 00:00:00

  • Development of the Preverbal Visual Assessment (PreViAs) questionnaire.

    abstract:BACKGROUND:Visual cognitive functions of preverbal infants are evaluated by means of a behavioral assessment. Parents or primary caregivers may be appropriate to certify the acquisition of certain abilities. AIMS:To develop the PreViAs (Preverbal Visual Assessment) questionnaire to assess visual behavior of infants un...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2014.01.012

    authors: Pueyo V,García-Ormaechea I,González I,Ferrer C,de la Mata G,Duplá M,Orós P,Andres E

    更新日期:2014-04-01 00:00:00

  • Psychomotor development and general movements in offspring of women with epilepsy and anticonvulsant therapy.

    abstract:UNLABELLED:While the role of antiepileptic drug (AED) therapy in teratogenesis has widely been investigated, there are few prospective studies on later postnatal development in offspring of epileptic women in utero exposed. The aim of this study was a prospective investigation of the psychomotor development in a select...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/s0378-3782(03)00083-5

    authors: Parisi P,Francia A,Vanacore N,Fiore S,Giallonardo AT,Manfredi M

    更新日期:2003-11-01 00:00:00

  • Qualitative changes of general movements in preterm infants with brain lesions.

    abstract::The aims of the study were (1) to replicate previous quantitative studies of motor activity in low-risk and high-risk preterm infants and (2) to apply a new method of systematic analysis of the qualitative characteristics of general movements in these two groups of infants. Sequential one-hour videorecordings of the u...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(90)90013-9

    authors: Ferrari F,Cioni G,Prechtl HF

    更新日期:1990-09-01 00:00:00

  • The early development of head control in preterm infants.

    abstract::This study documents the longitudinal development of head control in 104 infants born at 25-33 weeks gestation. Protective side turning of the head was found to have a developmental sequence of reducing spinal extension. In the 93 infants with normal motor outcome, individual differences in the rate of development cor...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(85)90074-x

    authors: Lacey JL,Henderson-Smart DJ,Edwards DA,Storey B

    更新日期:1985-09-01 00:00:00

  • Fatty acid utilization in perinatal de novo synthesis of tissues.

    abstract::The fatty acid content of fetal tissues was utilized to estimate essential fatty acid accretion during intrauterine growth. These rates of essential fatty acid accretion were used to predict that 400 mg/kg of body weight for omega-6 fatty acids and 50 mg/kg of body weight for omega-3 fatty acids per day would be used ...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(81)90016-5

    authors: Clandinin MT,Chappell JE,Heim T,Swyer PR,Chance GW

    更新日期:1981-09-01 00:00:00

  • Early behaviour and development in breast-fed premature infants are influenced by omega-6 and omega-3 fatty acid status.

    abstract:BACKGROUND:The requirement of essential fatty acids (EFA) for the development of the brain is well documented. OBJECTIVE:To investigate the early neurological development at term and 44 weeks gestational age in preterm infants in relation to EFA concentrations in breast milk and in infants' and mothers' plasma phospho...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2010.05.017

    authors: Lundqvist-Persson C,Lau G,Nordin P,Strandvik B,Sabel KG

    更新日期:2010-07-01 00:00:00

  • Need for a standardized procedure in the preparation of phenylalanine calibrators.

    abstract:INTRODUCTION:Sensitive screening for phenylketonuria (PKU) and other disorders requires accurate measurement of analytes in blood eluted from filter paper. The development of new quantitative methods for phenylalanine measurement in dried blood spots for PKU screening has introduced an increased number of calibrators p...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(96)01762-8

    authors: Dhondt JL,Paux E,Farriaux JP

    更新日期:1996-07-19 00:00:00

  • Epidemiology of prenatal smoking and perinatal outcomes.

    abstract:UNLABELLED:During the previous two decades smoking among pregnant women in the developed world declined by about 60-75%. Nevertheless, prenatal smoking remains a common habit and accounts for a significant proportion of fetal morbidity and mortality through both a direct (fetal) and an indirect (placental) effect. The ...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/j.earlhumdev.2007.08.002

    authors: Salihu HM,Wilson RE

    更新日期:2007-11-01 00:00:00

  • Interaction and development in the first year. I. The effects of prematurity.

    abstract::Six month infant-mother interaction patterns were observed and 10 month Bayley MDI scores were obtained in 10 fullterm and 14 healthy preterm (less than 37 weeks) infants. Relationships among interaction parameters and intellectual performance are compared with those among earlier interaction patterns and development....

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(86)90008-3

    authors: Watt J

    更新日期:1986-04-01 00:00:00

  • gamma-Aminobutyric acid concentrations in the cerebrospinal fluid of newborn infants.

    abstract::gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(82)90007-x

    authors: Hedner T,Iversen K,Lundborg P

    更新日期:1982-10-01 00:00:00

  • Father-infant interaction at the first contact after delivery.

    abstract::The behavior exhibited by human fathers at their first contact with the young was studied on 15 fathers of full-term infants delivered by cesarean section. The naked infant was presented to the father approximately 15 min after delivery, and photographs were taken every second during the first 7 min of contact. An ord...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(79)90017-3

    authors: Rödholm M,Larsson K

    更新日期:1979-03-01 00:00:00

  • Autoregulation of brain blood flow in the newborn piglet: regional differences in flow reduction during hypotension.

    abstract::The potential use of a piglet as a model for investigation of brain blood flow was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn piglets. Blood pressure was altered by phlebotomy. When the mean arterial blood pressure was greater than 50 mm Hg, no significant change in bra...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(82)90063-9

    authors: Laptook A,Stonestreet BS,Oh W

    更新日期:1982-01-01 00:00:00

  • Withholding or withdrawal of life sustaining treatment for newborn infants.

    abstract::In the last two decades the survival of extreme preterm infants and sick newborn infants has improved significantly due to the advances in perinatal medicine. Despite this advance, for some babies, withholding or withdrawal of life sustaining treatment may be the best option in the interest of the baby. An overview of...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/j.earlhumdev.2012.01.002

    authors: Aladangady N,de Rooy L

    更新日期:2012-02-01 00:00:00

  • Pilot study of the systemic effects of three different screening methods used for retinopathy of prematurity.

    abstract:PURPOSE:This pilot study compared the physiological and behavioural changes in premature infants undergoing three different methods of screening for retinopathy of prematurity (ROP). STUDY DESIGN:Prospective randomized cross-over pilot study. SUBJECTS AND METHODS:Fifteen premature infants requiring screening for ROP ...

    journal_title:Early human development

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.earlhumdev.2004.09.005

    authors: Mehta M,Adams GG,Bunce C,Xing W,Hill M

    更新日期:2005-04-01 00:00:00

  • Effect of early intervention on functional outcome at school age: Follow-up and process evaluation of a randomised controlled trial in infants at risk.

    abstract:BACKGROUND:The long-term effect of early intervention in infants at risk for developmental disorders is unclear. The VIP project (n=46, originally) evaluated by means of a randomised controlled trial the effect of the family centred early intervention programme COPCA (Coping with and Caring for infants with special nee...

    journal_title:Early human development

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.earlhumdev.2017.02.002

    authors: Hamer EG,Hielkema T,Bos AF,Dirks T,Hooijsma SJ,Reinders-Messelink HA,Toonen RF,Hadders-Algra M

    更新日期:2017-01-01 00:00:00

  • Effect of gestation length on the levels of five innate defence proteins in human milk.

    abstract:BACKGROUND:Human milk contains a range of host defence proteins that appear to contribute to health and wellbeing, but their variability in abundance among individuals has not been very well characterised. Milk from mothers of premature infants has altered composition, but the effect of gestation length on the host-def...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2014.11.006

    authors: Broadhurst M,Beddis K,Black J,Henderson H,Nair A,Wheeler T

    更新日期:2015-01-01 00:00:00

  • Nutrition and growth in infants born preterm from birth to adulthood.

    abstract::Prevention of extra-uterine growth retardation is of extreme importance, as the achievement of adequate growth has been associated with a favorable neurodevelopmental outcome through childhood. In addition, as disturbances in growth that take place early in life may affect adult health, a full understanding of the gro...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/j.earlhumdev.2013.08.004

    authors: Giannì ML,Roggero P,Garbarino F,Bracco B,Fumagalli M,Agosti M,Mosca F

    更新日期:2013-10-01 00:00:00

  • Ultrasound evolution and later outcome of infants with periventricular densities.

    abstract::The evolution of ultrasound findings in 59 infants with transient periventricular densities is described and the neurodevelopmental outcome of 53 of these infants was compared with 92 of 107 infants with normal ultrasound scans, born during the same 24-month period. Four of the 53 infants with transient periventricula...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(88)90103-x

    authors: De Vries LS,Regev R,Pennock JM,Wigglesworth JS,Dubowitz LM

    更新日期:1988-03-01 00:00:00

  • Oesophageal motor activity and sleep state in the newborn human infant.

    abstract::Oesophageal pressure and ventilation were recorded during sleep in healthy full-term neonates with sleep state defined by one of two methods; in 35 infants by combined behavioural and electroencephalographic criteria, and in a further 13 infants by behavioural criteria alone. Spontaneous oesophageal contractions occur...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(88)90054-0

    authors: Manning DJ,Bowden PJ,Hathorn MK,Stothers JK

    更新日期:1988-12-01 00:00:00

  • A low incidence of preoperative neurosonographic abnormalities in neonates with heart defects.

    abstract:BACKGROUND AND AIM:To investigate whether neonates with prenatally detected congenital heart defects (CHD) demonstrate cerebral abnormalities on early preoperative cranial ultrasound (CUS), compared to healthy neonates, and to measure brain structures to assess brain growth and development in both groups. STUDY DESIGN...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2020.105097

    authors: Jansen FAR,Haak MC,van Wesemael MS,Ten Harkel ADJD,van Lith JMM,Blom NA,Steggerda SJ

    更新日期:2020-09-01 00:00:00

  • Heart rate variability in healthy term newborns: the contribution of respiratory sinus arrhythmia.

    abstract::Cardiorespiratory interactions in healthy full term newborns were investigated. Spectral analysis was used on heart rate and breathing data from 22 neonates 2-5 days old to reveal coincident frequencies in the breathing and heart rate variability (HRV) spectra, thus identifying respiratory sinus arrhythmia (RSA). The ...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(93)90197-3

    authors: Thompson CR,Brown JS,Gee H,Taylor EW

    更新日期:1993-01-01 00:00:00