Abstract:
:Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is a temporal relationship apnea may be more likely to predispose to GER via esophageal sphincter relaxation than vice versa. Measurement of multiple intraluminal impedance via esophageal catheter in addition to esophageal pH has enhanced our understanding of GER, although it also did not demonstrate a causal relationship between apnea and GER. The incidence of GER may be modified by thickening feeds and position change without adverse effects. In contrast, pharmacotherapy including acid suppression therapy may have adverse effects and should only be used in infants with clear evidence of clinical benefit.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Abu Jawdeh EG,Martin RJdoi
10.1016/S0378-3782(13)70005-7subject
Has Abstractpub_date
2013-06-01 00:00:00pages
S14-6eissn
0378-3782issn
1872-6232pii
S0378-3782(13)70005-7journal_volume
89 Suppl 1pub_type
杂志文章,评审abstract::Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00077-2
更新日期:1999-01-01 00:00:00
abstract::Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(83)90068-3
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decrea...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.01.001
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Improved neonatal survival data have been reported following early preterm prelabour rupture of membranes (PPROM) prior to 25 weeks gestation with a prolonged latency to delivery and persistent oligohydramnios. However, data regarding long-term respiratory and neurological morbidity are lacking. AIMS:To eva...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.01.012
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Preterm birth is a known risk factor for infant development but it is less clear whether fetal growth restriction (FGR) and early term birth between 37 and 39 weeks gestation are associated with risks for infant development. AIMS:This study investigated risk factors for adverse developmental outcomes at 12 ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.104951
更新日期:2020-03-01 00:00:00
abstract::Low birthweight has been associated with diseases and disorders later in life. It has been suggested that this is caused by the impaired development of abdominal organs, especially in cases of growth retardation. Besides general malnutrition of the fetus, preferential bloodflow to the heart and brain may further depri...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(97)00073-x
更新日期:1998-04-17 00:00:00
abstract:BACKGROUND:Term equivalent age (TEA) brain MRI identifies preterm infants at risk for adverse neurodevelopmental outcomes. But some infants may experience neurodevelopmental impairments even in the absence of neuroimaging abnormalities. OBJECTIVE:Evaluate the association of TEA amplitude-integrated EEG (aEEG) measures...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2018.02.010
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.06.006
更新日期:2011-12-01 00:00:00
abstract::Fifty-one British newborn infants and 51 Japanese newborn infants were compared using Prechtl's neonatal neurological examination and Brazelton's neonatal behavioural assessment scale on the 5th day after birth. Statistically significant differences were found between the two groups. British infants were more responsi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90172-d
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Visual cognitive functions of preverbal infants are evaluated by means of a behavioral assessment. Parents or primary caregivers may be appropriate to certify the acquisition of certain abilities. AIMS:To develop the PreViAs (Preverbal Visual Assessment) questionnaire to assess visual behavior of infants un...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.01.012
更新日期:2014-04-01 00:00:00
abstract:UNLABELLED:While the role of antiepileptic drug (AED) therapy in teratogenesis has widely been investigated, there are few prospective studies on later postnatal development in offspring of epileptic women in utero exposed. The aim of this study was a prospective investigation of the psychomotor development in a select...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(03)00083-5
更新日期:2003-11-01 00:00:00
abstract::The aims of the study were (1) to replicate previous quantitative studies of motor activity in low-risk and high-risk preterm infants and (2) to apply a new method of systematic analysis of the qualitative characteristics of general movements in these two groups of infants. Sequential one-hour videorecordings of the u...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90013-9
更新日期:1990-09-01 00:00:00
abstract::This study documents the longitudinal development of head control in 104 infants born at 25-33 weeks gestation. Protective side turning of the head was found to have a developmental sequence of reducing spinal extension. In the 93 infants with normal motor outcome, individual differences in the rate of development cor...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90074-x
更新日期:1985-09-01 00:00:00
abstract::The fatty acid content of fetal tissues was utilized to estimate essential fatty acid accretion during intrauterine growth. These rates of essential fatty acid accretion were used to predict that 400 mg/kg of body weight for omega-6 fatty acids and 50 mg/kg of body weight for omega-3 fatty acids per day would be used ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(81)90016-5
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:The requirement of essential fatty acids (EFA) for the development of the brain is well documented. OBJECTIVE:To investigate the early neurological development at term and 44 weeks gestational age in preterm infants in relation to EFA concentrations in breast milk and in infants' and mothers' plasma phospho...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.05.017
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Sensitive screening for phenylketonuria (PKU) and other disorders requires accurate measurement of analytes in blood eluted from filter paper. The development of new quantitative methods for phenylalanine measurement in dried blood spots for PKU screening has introduced an increased number of calibrators p...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(96)01762-8
更新日期:1996-07-19 00:00:00
abstract:UNLABELLED:During the previous two decades smoking among pregnant women in the developed world declined by about 60-75%. Nevertheless, prenatal smoking remains a common habit and accounts for a significant proportion of fetal morbidity and mortality through both a direct (fetal) and an indirect (placental) effect. The ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2007.08.002
更新日期:2007-11-01 00:00:00
abstract::Six month infant-mother interaction patterns were observed and 10 month Bayley MDI scores were obtained in 10 fullterm and 14 healthy preterm (less than 37 weeks) infants. Relationships among interaction parameters and intellectual performance are compared with those among earlier interaction patterns and development....
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(86)90008-3
更新日期:1986-04-01 00:00:00
abstract::gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90007-x
更新日期:1982-10-01 00:00:00
abstract::The behavior exhibited by human fathers at their first contact with the young was studied on 15 fathers of full-term infants delivered by cesarean section. The naked infant was presented to the father approximately 15 min after delivery, and photographs were taken every second during the first 7 min of contact. An ord...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(79)90017-3
更新日期:1979-03-01 00:00:00
abstract::The potential use of a piglet as a model for investigation of brain blood flow was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn piglets. Blood pressure was altered by phlebotomy. When the mean arterial blood pressure was greater than 50 mm Hg, no significant change in bra...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90063-9
更新日期:1982-01-01 00:00:00
abstract::In the last two decades the survival of extreme preterm infants and sick newborn infants has improved significantly due to the advances in perinatal medicine. Despite this advance, for some babies, withholding or withdrawal of life sustaining treatment may be the best option in the interest of the baby. An overview of...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2012.01.002
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:This pilot study compared the physiological and behavioural changes in premature infants undergoing three different methods of screening for retinopathy of prematurity (ROP). STUDY DESIGN:Prospective randomized cross-over pilot study. SUBJECTS AND METHODS:Fifteen premature infants requiring screening for ROP ...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2004.09.005
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:The long-term effect of early intervention in infants at risk for developmental disorders is unclear. The VIP project (n=46, originally) evaluated by means of a randomised controlled trial the effect of the family centred early intervention programme COPCA (Coping with and Caring for infants with special nee...
journal_title:Early human development
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2017.02.002
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Human milk contains a range of host defence proteins that appear to contribute to health and wellbeing, but their variability in abundance among individuals has not been very well characterised. Milk from mothers of premature infants has altered composition, but the effect of gestation length on the host-def...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.11.006
更新日期:2015-01-01 00:00:00
abstract::Prevention of extra-uterine growth retardation is of extreme importance, as the achievement of adequate growth has been associated with a favorable neurodevelopmental outcome through childhood. In addition, as disturbances in growth that take place early in life may affect adult health, a full understanding of the gro...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.08.004
更新日期:2013-10-01 00:00:00
abstract::The evolution of ultrasound findings in 59 infants with transient periventricular densities is described and the neurodevelopmental outcome of 53 of these infants was compared with 92 of 107 infants with normal ultrasound scans, born during the same 24-month period. Four of the 53 infants with transient periventricula...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(88)90103-x
更新日期:1988-03-01 00:00:00
abstract::Oesophageal pressure and ventilation were recorded during sleep in healthy full-term neonates with sleep state defined by one of two methods; in 35 infants by combined behavioural and electroencephalographic criteria, and in a further 13 infants by behavioural criteria alone. Spontaneous oesophageal contractions occur...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(88)90054-0
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND AND AIM:To investigate whether neonates with prenatally detected congenital heart defects (CHD) demonstrate cerebral abnormalities on early preoperative cranial ultrasound (CUS), compared to healthy neonates, and to measure brain structures to assess brain growth and development in both groups. STUDY DESIGN...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105097
更新日期:2020-09-01 00:00:00
abstract::Cardiorespiratory interactions in healthy full term newborns were investigated. Spectral analysis was used on heart rate and breathing data from 22 neonates 2-5 days old to reveal coincident frequencies in the breathing and heart rate variability (HRV) spectra, thus identifying respiratory sinus arrhythmia (RSA). The ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(93)90197-3
更新日期:1993-01-01 00:00:00