Abstract：
BACKGROUND:Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decreased in sick infants, it is not known if physical condition influences TTR levels. Serial concentrations of TTR following birth have not previously been reported. AIMS:To measure serial serum concentrations of TTR in premature infants following birth, and determine whether TTR levels are related to physical condition. METHODS:A cohort of 65 premature very low birth weight (VLBW) and LBW infants were studied. Serum samples were obtained on the day of birth, and for 8 weeks following birth. Apgar scores at birth as well as the incidence of respiratory distress syndrome (RDS) were noted. RESULTS:Baseline serum T4 concentrations and Apgar scores were significantly lower in VLBW infants, while the severity of RDS was significantly higher in the VLBW group. Multivariate analyses revealed that T4 levels were negatively associated with RDS, while TSH concentrations were positively related to gestational age. TTR concentrations were not related to gestational age at birth, Apgar score, or RDS, and did not change markedly over 8 weeks. CONCLUSIONS:These findings suggest that serum TTR concentrations are not related to birth weight/gestational age and are not associated with either clinical condition at birth (as assessed by Apgar score) or the occurrence of RDS. Reference values for TTR concentrations in VLBW and LBW infants are provided from birth to 8 weeks of age.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Su PH,Wang SL,Chen JY,Hu JM,Chang HP,Chen SJdoi
10.1016/j.earlhumdev.2008.01.001subject
Has Abstractpub_date
2008-08-01 00:00:00pages
533-8issue
8eissn
0378-3782issn
1872-6232pii
S0378-3782(08)00005-4journal_volume
84pub_type
杂志文章abstract：:Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct inte...
journal_title：Early human development
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journal_title：Early human development
pub_type： 杂志文章,评审
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journal_title：Early human development
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journal_title：Early human development
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abstract：BACKGROUND:Several studies report increased minor neurodevelopment dysfunctions in children born very low birth weight (VLBW). Usefulness of preventive early intervention programs to improve neurodevelopment outcome of VLBW infants is still under investigation. AIMS:To evaluate the effects of an early post-discharge d...
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pub_type： 杂志文章,随机对照试验
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更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the preschool neurodevelopmental outcome in CDH survivors between 2 and 5 years of age and to identify perinatal and postnatal factors that may be predictive of persistent neurological deficits. METHODS:The study cohort consists of 60 CDH survivors that were enrolled in our prospective, follow-up...
journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章,多中心研究
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更新日期：2014-08-01 00:00:00
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journal_title：Early human development
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更新日期：1996-12-30 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.08.015
更新日期：2014-12-01 00:00:00
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journal_title：Early human development
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更新日期：2020-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1997-01-03 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90163-b
更新日期：1992-06-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Natural cell death due to apoptotic mechanisms has been described in various species. Relatively few studies examined this process in humans. AIM:To investigate the distribution of apoptosis in fetal brain tissue. DESIGN:We examined apoptosis in the frontal region of human fetal brain by the TUNEL method i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(02)00116-0
更新日期：2003-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2006-05-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-07-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1982-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.08.015
更新日期：2015-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：1993-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00100-5
更新日期：1999-04-01 00:00:00
