Abstract：
:A review of the conundrum called mild hypoxic-ischemic encephalopathy (HIE) is provided. During the past decades, the definition of HIE has evolved to accommodate the short window of time required for the initiation of therapeutic hypothermia. Also, neurological evaluations have changed with the use of simpler staging systems that can be applied within the first 6 h of life. In this review, we discuss the challenges in the identification of newborns with "mild HIE" within 6 h after birth, the limitations in the existing early biomarkers of brain injury, and the current knowledge gaps in the long term neurodevelopmental outcomes of infants diagnosed with mild HIE. Progress in the understanding of mild HIE and its sequelae continues to be hindered by the lack of a standardized definition for mild HIE that will reliably identify at-risk infants who may benefit from neuroprotective strategies.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Chalak L,Latremouille S,Mir I,Sánchez PJ,Sant'Anna Gdoi
10.1016/j.earlhumdev.2018.02.008subject
Has Abstractpub_date
2018-05-01 00:00:00pages
88-94eissn
0378-3782issn
1872-6232pii
S0378-3782(18)30125-7journal_volume
120pub_type
杂志文章,评审abstract：:Whenever possible, oral feeding is the preferred method in neonatal feeding. However, many premature infants are unable to suck and swallow effectively; in these cases alternative methods of nutrient delivery must be used. We briefly review the different feeding methods used in neonatal units, with particular attentio...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(12)70011-7
更新日期：2012-05-01 00:00:00
abstract：:ELISA methods were used to determine the concentrations of CAI and CAII in spermatozoa, seminal plasma, ovarian follicular fluid, decidual tissues, chorionic villi and various fetal tissues at 8-11 weeks gestation. Both CAI and CAII were expressed in all subjects except ovarian follicular fluid samples. The possible p...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00119-9
更新日期：1998-07-10 00:00:00
abstract：:Increasing public awareness of the prone sleeping position, maternal smoking and overheating as potentially avoidable risk factors for the sudden infant death syndrome (SIDS) has been accompanied by a dramatic reduction in mortality. The results of two population based studies of SIDS in Avon are compared; the first o...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90208-9
更新日期：1994-09-15 00:00:00
abstract：:The diagnosis, acute management and follow-up of neonates with haemolytic disease of the newborn (HDN) still represents a significant area of activity for maternity/neonatal services. ABO incompatability is now the single largest cause of HDN in the western world. However, with increasing knowledge at the molecular le...
journal_title：Early human development
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.earlhumdev.2008.06.005
更新日期：2008-08-01 00:00:00
abstract：:Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct inte...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2010.01.008
更新日期：2010-07-01 00:00:00
abstract：:Interfacility transport is a necessary part of hospital care. Neonates often need to access specialist input at different sites necessitating a reliable transfer process. Services have evolved significantly over the last ten years to meet this need. This followed the recognition that ad hoc arrangements were unreliabl...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:A new protocol for Structured Observation of Motor Performance in Infants, SOMP-I, designed to describe both progress and quality of motor performance, was evaluated concerning its ability to describe and to discriminate between the motor performance observed in different groups of infants. Sixty-eight infants born at...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01678-3
更新日期：1995-11-24 00:00:00
abstract：:Cord blood thyroxine (T4) concentrations were measured in 4,068 infants from 28 wk gestation to term. Each chart was reviewed for the following factors: delivery by cesarean section, prolonged rupture of membranes, neonatal asphyxia, meconium-stained amniotic fluid, maternal diabetes mellitus and twinning. Each neonat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(78)90031-2
更新日期：1978-09-01 00:00:00
abstract：:Low birthweight has been associated with diseases and disorders later in life. It has been suggested that this is caused by the impaired development of abdominal organs, especially in cases of growth retardation. Besides general malnutrition of the fetus, preferential bloodflow to the heart and brain may further depri...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00073-x
更新日期：1998-04-17 00:00:00
abstract：BACKGROUND:The assessment of the quality of general movements (GMs) in young infants is a reliable and valid diagnostic tool for detecting brain dysfunction early in life. Of special interest is a type of GMs called fidgety movements (FMs) characteristic for 3- to 5-month-old infants. GMs are part of an infant's sponta...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.01.004
更新日期：2004-04-01 00:00:00
abstract：:The validity of the Wigglesworth experimental model to produce newborn rats that are small for gestational age by ligation of one of both uterine vessels was confirmed. Newborn rats from the opposite horns are used as controls in the classical model. It is concluded from this study that newborns from sham-operated dam...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90038-0
更新日期：1979-09-01 00:00:00
abstract：:The biochemical, dermatological and neurological motor disorders of biotinidase deficiency (multiple carboxylase deficiency) show a dramatic response to pharmacological doses of biotin. This condition is characterised by the accumulation of biocytin and depletion of biotin. Neuromuscular function returns to normal wit...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90086-6
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND:Higher parenting stress in mothers of children born very preterm may be in part a response to poorer neurobehavioral development, reflecting realistic concerns in addition to adaptation to the trauma of preterm delivery. To our knowledge, there are few longitudinal studies of parenting stress that have addre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.01.030
更新日期：2011-04-01 00:00:00
abstract：:Newborn infants fulfil some criteria of being conscious i.e. being aware of the body, the self and the world. They are able to differentiate between self and nonself touch, express emotions and show signs of shared feelings. They process sensory impressions including pain at a cortical level. They remember rhythmic so...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2009.08.017
更新日期：2009-10-01 00:00:00
abstract：INTRODUCTION:Little is known about sex differences in human fetal heart and behaviour. PATIENTS AND METHODS:One hundred twenty-three nulliparous healthy women carrying a male (n=56) or female (n=67) fetus participated in this study. All pregnancies remained uncomplicated and delivery was uneventful. Ultrasound observa...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(03)00047-1
更新日期：2003-08-01 00:00:00
abstract：:Phosphatidylcholine (PC) is the predominant phospholipid in natural surfactant preparations. A metabolic intermediate, lyso-PC, is potentially injurious to the lungs. In the present study, tracheal aspirates from preterm babies with respiratory distress syndrome treated with surfactant were examined for the presence o...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)01885-9
更新日期：1997-09-19 00:00:00
abstract：BACKGROUND:Routine oropharyngeal suctioning in term vigorous neonates immediately after birth is a questionable practice. Current recommendations favor suctioning only in the presence of considerable obstruction due to secretions, blood or other matter. We aimed to analyze the influence of oropharyngeal suctioning on c...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.01.005
更新日期：2015-02-01 00:00:00
abstract：:The Golgi-Cox method was used to study the maturation of the large pyramidal cells of the Vth cortical layer in three groups of adult rats: one subjected to undernutrition during the first month of life, another throughout the first 2 mth of life, and the last one during gestation and the suckling period. The main alt...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90186-6
更新日期：1986-12-01 00:00:00
abstract：INTRODUCTION:The sex ratio at birth (usually denoted as M/T=male divided by total births) is influenced by cultural factors. The Chinese Zodiac holds that women born in the Fire Horse year (1966) would be unlucky. It has been shown that significantly less children were born in Japan in this year. This study was carried...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.08.011
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Intrauterine growth restriction (IUGR) is a fetal condition characterized by growth-rate reduction. Afflicted fetuses tend to display abnormalities in heart rate. OBJECTIVE:To study the differences in the heart-rate variability of low-risk fetuses and IUGR fetuses during different behavioral states. METHOD...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.07.002
更新日期：2013-10-01 00:00:00
abstract：:The modern successes of reproductive medicine are based on the achievements in the fields of artificial fertilization and cryobiology over the last 50years. Cryopreservation of oocytes makes it possible to preserve their reproductive potential after surgical interventions, treatment of cancer, for delayed pregnancy an...
journal_title：Early human development
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.earlhumdev.2018.08.016
更新日期：2018-11-01 00:00:00
abstract：:Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life. Gastro-oesophageal reflux may be a primary gastro-intestinal motility disorder, but it may also be secondary to other conditions such as cow's milk protein allergy. Objective diagnosis can be ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.10.011
更新日期：2005-12-01 00:00:00
abstract：:Placental tissue from five women undergoing elective caesarean did not present differences in fatty acids or mRNA expression of FATP-1, FATP-4 and H-FABP in different placental locations. mRNA expression of FATP-1 and FATP-4 was significantly higher than H-FABP. The expression of L-FABP was too low in placenta for acc...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.02.001
更新日期：2006-10-01 00:00:00
abstract：:Hepatic glucose production by glycogenolysis and gluconeogenesis is essential to maintain blood glucose levels, and the glucose-6-phosphatase system catalyses the terminal step of both pathways. Developmental delays in the postnatal up-regulation of hepatic glucose-6-phosphatase enzyme activity are common in preterm i...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.005
更新日期：2005-01-01 00:00:00
abstract：:Spectral analysis was performed on ventilation and instantaneous heart rate data recorded in 15 term infants during quiet sleep in the first week after delivery, and in 11 of these infants during active sleep. There was a close relation between the main peaks of the ventilation spectra and the corresponding histograms...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90050-9
更新日期：1989-11-01 00:00:00
abstract：:One hundred consecutive cranial computed tomographic scans were reviewed in children aged 0-2 years, presenting to the Royal Belfast Hospital for Sick Children. The mean age at scanning was 8.3 months and 73% of the scans were abnormal. The majority of scans were performed electively (78%). The commonest indication fo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90011-q
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:Movement by an infant during the first year of life might influence its activity level and thereby influence growth in early childhood. AIM:To examine whether the time that an infant is able to move unrestrictedly and time spent in baby seats are related to weight and waist circumference at age 9 months and...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：:We have investigated 20 healthy full-term newborns between the 4th and the 6th day of life in standard conditions for laterality of arm movements, before and after introduction of a target. The durations of recording were: (a) 5 min continuously before target introduction; (b) five 1-min units during target presentati...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90099-6
更新日期：1989-04-01 00:00:00
abstract：:The potential use of a piglet as a model for investigation of brain blood flow was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn piglets. Blood pressure was altered by phlebotomy. When the mean arterial blood pressure was greater than 50 mm Hg, no significant change in bra...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90063-9
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:Fluconazole prophylaxis has demonstrated efficacy in single and multicenter randomized controlled trials without side effects or emergence of resistance. Additional evidence based on incidence of invasive Candida infections, multicenter data, resistance, and safety is desired. METHODS:We conducted a case-co...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0378-3782(14)70026-X
更新日期：2014-03-01 00:00:00
