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Lyso-phosphatidylcholine and outcome of preterm babies with respiratory distress syndrome treated with surfactant.

Abstract：

:Phosphatidylcholine (PC) is the predominant phospholipid in natural surfactant preparations. A metabolic intermediate, lyso-PC, is potentially injurious to the lungs. In the present study, tracheal aspirates from preterm babies with respiratory distress syndrome treated with surfactant were examined for the presence of lyso-PC to determine if there was any correlation with outcome. Eighteen babies were assigned to receive initially either 100 or 200 mg/kg Curosurf followed by up to three further 100-mg/kg doses if required. Lyso-PC was present in aspirates taken 12-24 h after the last treatment from nine of 11 infants who initially received 200 mg/kg but in only one from seven receiving 100 mg/kg initially, and was dependent on the total dose of phospholipid administered. Three babies in the low-dose group developed bronchopulmonary dysplasia, whereas two in the high-dose group were non-survivors, however we could not correlate the presence of lyso-PC with adverse long-term outcome in this group of preterm infants.

journal_name

Early Hum Dev

journal_title

Early human development

authors

O'Hare MM,Bingham AM,McMaster C,Halahakoon WL,Corcoran JD,Halliday HL

doi

10.1016/s0378-3782(97)01885-9

subject

Has Abstract

pub_date

1997-09-19 00:00:00

pages

135-41

issue

2

eissn

0378-3782

issn

1872-6232

pii

S0378378297018859

journal_volume

49

pub_type

杂志文章

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