Abstract:
BACKGROUND:Neonatal sepsis has been associated with poor neurodevelopmental outcome, however the evidence regarding the exact mechanism of the inflammation to the developing neonatal brain are inconclusive. AIMS:To investigate association between cerebral oxygenation during neonatal sepsis and neurodevelopmental outcome. STUDY DESIGN:Follow-up assessment of a previously described prospective case-control study. SUBJECTS:A cohort of late preterm (34-37 weeks' gestation) and preterm (<34 weeks' gestation) infants with sepsis and healthy controls, evaluated at 18-24 months of corrected gestational age with Bayley-III Scales for Infant and Toddler Development (BSID-III). OUTCOME MEASURES:To evaluate the association between cerebral tissue oxygenation index (cTOI) and fractional tissue oxygen extraction (FTOE), measured with near-infrared spectroscopy, during sepsis and the composite cognitive and motor index scores. RESULTS:Thirty-one infants with blood culture confirmed neonatal sepsis and thirty-five controls were recruited. The cerebral oxygenation was significantly lower in septic neonates, compared to controls (61 ± 7 compared to 72 ± 5; p < 0.001). Infants with sepsis had significantly lower cognitive and motor index scores and higher proportion of suboptimal cognitive (16% compared to 3%, p = 0.045) and motor (16% compared to none, p = 0.008) index score. The low mean cTOI and FTOE noted in septic infants were significantly associated with worse cognitive and motor composite index scores. CONCLUSIONS:Infants with lower cerebral oxygenation during neonatal sepsis are at increased risk of worse cognitive and motor scores in the neurodevelopmental assessment.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Rallis D,Karagianni P,Goutsiou E,Soubasi-Griva V,Banerjee J,Tsakalidis Cdoi
10.1016/j.earlhumdev.2019.07.008subject
Has Abstractpub_date
2019-09-01 00:00:00pages
49-53eissn
0378-3782issn
1872-6232pii
S0378-3782(19)30236-1journal_volume
136pub_type
杂志文章abstract::Abnormal hypertonia of the neck extensor muscles in newborns may be appreciated by observing spontaneous posture, evaluating resistance to repeated passive flexion of the head, and eliciting the head straightening reflexes. This sign correlates well with other signs of insult to the central nervous system. Of 1743 new...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(77)90019-6
更新日期:1977-10-01 00:00:00
abstract::Index and regression methods of selecting babies whose heads are out of proportion to their body weight are examined and compared. The ratios head circumference3/birthweight and head circumference3/birthweightP (where P is a power found by regression methods) are used, and the regression of head circumference 3 on bir...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(80)90039-0
更新日期:1980-12-01 00:00:00
abstract:OBJECTIVE:To assess patterns of nutritive sucking in very preterm infants ≤32 weeks of gestation. STUDY DESIGN:Very preterm infants who attained independent oral feeding were prospectively assessed with an instrumented feeding bottle that measures nutritive sucking. The primary outcome measure was nutritive sucking pe...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105044
更新日期:2020-07-01 00:00:00
abstract::Candidal chorioamnionitis is an uncommon and apparently rather indolent intrauterine infection in which the fetus is able to marshal some of the immunological forces at its disposal against an easily visualized antigen impinging on lung mucosal surfaces. In a retrospective histological study of one of the largest repo...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90113-6
更新日期:1985-05-01 00:00:00
abstract::Posture and spontaneous motor patterns during the first days of life were studied in ten healthy fullterm infants by direct observation and videorecording. The aim of the study was to provide a description of motor and postural characteristics of normal newborns. The infants were recorded for 1 h on their first and fo...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(89)90020-0
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:The second-to-fourth digit ratio (2D:4D) reflects prenatal estrogen and testosterone exposure, and is established in utero. Sex steroids are implicated in development and progression of primary brain tumors. AIMS:To investigate whether there is a link between 2D:4D ratio and primary brain tumors, and age at...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.10.003
更新日期:2016-12-01 00:00:00
abstract::Here presented are the different human fetal larynx functions. Analysis and observation of the organ show at least three behavioural patterns: swallowing, respiratory and phonetic. The respiratory function coincides with a blood aspiration through the venosus duct (phenomenon measured by pulsed Doppler) which increase...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01721-6
更新日期:1996-07-05 00:00:00
abstract::Neonatal sepsis is frequently accompanied by significant and sometimes life-threatening coagulopathy. More complete understanding is needed of the molecular and cellular mechanisms underlying the interaction of the inflammatory and hemostatic systems. Such information may help focus future studies toward novel ways to...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(14)70008-8
更新日期:2014-03-01 00:00:00
abstract::The transitional circulation of the preterm infant differs significantly from the term infant. The preterm infant is uniquely at risk of hypotension and low systemic blood flow states due to failure or delay in the normal transitional circulation processes. The maintenance of normal tissue oxygenation requires mainten...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2005.03.006
更新日期:2005-05-01 00:00:00
abstract::Standards for Research (StaR) in Child Health, founded in 2009, addresses the current scarcity of and deficiencies in pediatric clinical trials. StaR Child Health brings together leading international experts devoted to developing practical, evidence-based standards to enrich the reliability and relevance of pediatric...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.09.011
更新日期:2013-11-01 00:00:00
abstract::The behavior exhibited by human fathers at their first contact with the young was studied on 15 fathers of full-term infants delivered by cesarean section. The naked infant was presented to the father approximately 15 min after delivery, and photographs were taken every second during the first 7 min of contact. An ord...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(79)90017-3
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children. AIMS:We aimed to investigate the perinatal and maternal risk factors involved in the development of chronic respiratory morbidity in preterm infants, with an emphasis on the importance of Foetal Inflamm...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.07.002
更新日期:2014-09-01 00:00:00
abstract::Cerebral blood flow velocity (CBFV) was measured using Doppler ultrasound on the first day of life in a consecutively admitted cohort of 52 very low birthweight infants. Recordings were made for a period of 1 min. The coefficient of variation for the area under the curve of 20 successive cardiac cycles was calculated,...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(96)01769-0
更新日期:1997-01-03 00:00:00
abstract::Oesophageal pressure and ventilation were recorded during sleep in healthy full-term neonates with sleep state defined by one of two methods; in 35 infants by combined behavioural and electroencephalographic criteria, and in a further 13 infants by behavioural criteria alone. Spontaneous oesophageal contractions occur...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(88)90054-0
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Birthweight is an important predictor of various fundamental aspects of childhood health and development. AIM:To examine the impact of birthweight on childhood balance performance classification and verify if this is replicable and consistent in different populations. STUDY DESIGN:Prospective birth cohort ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2018.01.010
更新日期:2019-03-01 00:00:00
abstract::The aim is to know whether antenatal olfactory learning have a greater effect than postnatal olfactory learning on infant feeding even in the absence of triggering signals. We evaluated the sucking behavior of infants completely separated from their mothers for 10-14 days since birth. The 12 infants admitted to Chiba ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2003.10.003
更新日期:2004-02-01 00:00:00
abstract::Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00077-2
更新日期:1999-01-01 00:00:00
abstract::Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-1 (IGFBP-1) were measured in amniotic fluid, extraembryonic coelomic fluid and maternal serum from 23 women with apparently normal first trimester pregnancies prior to termination. The levels of IGF-1 and IGFBP-1 were significantly hig...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90105-p
更新日期:1992-02-01 00:00:00
abstract::Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life. Gastro-oesophageal reflux may be a primary gastro-intestinal motility disorder, but it may also be secondary to other conditions such as cow's milk protein allergy. Objective diagnosis can be ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2005.10.011
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:The importance of an infant's intra-oral vacuum in milk removal from the breast has been established. However, the relationship between the vacuum curve and milk transfer is not well understood. AIMS:To investigate the parameters of the infant suck cycle in relation to the volume of milk removed from the br...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.02.003
更新日期:2016-05-01 00:00:00
abstract::Case-control studies are frequently performed in prenatal and perinatal epidemiology. For data collection, these studies often rely on self-administered questionnaires or personal interviews. Although of importance, validation of these measurement instruments received little attention in epidemiologic research so far....
journal_title:Early human development
pub_type: 评论,信件
doi:10.1016/j.earlhumdev.2010.09.372
更新日期:2011-01-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.04.007
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Few studies describe in detail the pregnancy and early development of infants with Prader-Willi syndrome (PWS). However, variations at these early stages may partially account for differences in the later phenotype. A recent paper described an abnormally high number of problems in pregnancy and early infancy...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2007.08.007
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:Extremely low birth weight (ELBW; <1kg) adolescents are at risk for special health care needs (SHCN) and poor math achievement compared to normal birth weight (NBW) peers. SHCN are associated with poor academic achievement among NBW children. We hypothesize that SHCN explain the effect of ELBW on math achiev...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2017.09.019
更新日期:2017-12-01 00:00:00
abstract::Maternal milk four days post partum contained immunoreactive calcitonin in concentrations which were 22-89 times higher than those noted in concomitantly sampled maternal sera. Neurotensin-like immunoreactivity was barely detectable in milk. It is suggested that calcitonin may be a prerequisite for the concentration o...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90060-3
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:The requirement of essential fatty acids (EFA) for the development of the brain is well documented. OBJECTIVE:To investigate the early neurological development at term and 44 weeks gestational age in preterm infants in relation to EFA concentrations in breast milk and in infants' and mothers' plasma phospho...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.05.017
更新日期:2010-07-01 00:00:00
abstract::The cephalocaudal progression of jaundice was studied in 136 mature, clinically well newborns. The yellow colour of the skin was measured with the transcutaneous bilirubinometer. Significant positive correlation was found between the yellow colour of the skin in four regions and the plasma bilirubin concentration (for...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90022-b
更新日期:1990-04-01 00:00:00
abstract::The possibility of assembling this series of Best Practice Guidelines papers pertaining to WASP (Write a Scientific Paper) arose from the international WASP course, and the realisation that the Statistics at Square One papers initially published in the British Medical Journal in the 1970s, dealing with medical statist...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.05.012
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Postural control differs between infants born preterm and full term at 1-3weeks of age. It is unclear if differences persist or alter the development of early behaviors. The aim of this longitudinal study was to compare changes in postural control variability during development of head control and r...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.01.006
更新日期:2014-03-01 00:00:00
abstract::The essential fatty acid (EFA) composition of umbilical vessel walls is increasingly being studied as a longer-term reflection of the fetal EFA status. We evaluated the EFA content of umbilical artery and vein vessel walls in 43 preterm infants and compared it with that of 43 full-term cord vessels. In addition, relat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01656-n
更新日期:1995-08-18 00:00:00