Abstract:
BACKGROUND:Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children. AIMS:We aimed to investigate the perinatal and maternal risk factors involved in the development of chronic respiratory morbidity in preterm infants, with an emphasis on the importance of Foetal Inflammatory Response Syndrome (FIRS). STUDY DESIGN:Prospective cohort study. SUBJECTS:Demographic, antenatal, delivery and outcomes data were collected from 262 infants with less than 32 completed weeks of gestational age, over a 10-year period. OUTCOME MEASURES:Presence of chronic lung disease of prematurity and early childhood wheezing. RESULTS:In multivariate logistic regression analysis the presence of FIRS appears to be the most important risk factor for both, chronic lung disease of prematurity (OR 31.05, 95% CI 10.7-87.75, p<0.001) and early childhood wheezing (OR 5.63, 95% CI 2.42-13.05, p=0.01). In the alternative regression model for early childhood wheezing, with chronic lung disease included as a variable, the statistical significance of FIRS completely vanished (OR 1.15, 95% CI 0.39-3.34, p=0.79), whilst chronic lung disease became the most important risk factor (OR 23.45, 95% CI 8.5-63.25, p<0.001). CONCLUSIONS:Prenatal and early neonatal events are of utmost importance in the development of chronic respiratory symptoms in children. The influence of FIRS on the development of chronic respiratory symptoms goes far beyond its impact on gestational age and may be related to direct inflammation-mediated lung tissue damage. CLD appears to be an intermittent step on the way from FIRS to ECW.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Dessardo NS,Dessardo S,Mustać E,Banac S,Petrović O,Peter Bdoi
10.1016/j.earlhumdev.2014.07.002subject
Has Abstractpub_date
2014-09-01 00:00:00pages
493-9issue
9eissn
0378-3782issn
1872-6232pii
S0378-3782(14)00161-3journal_volume
90pub_type
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journal_title:Early human development
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journal_title:Early human development
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journal_title:Early human development
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doi:10.1016/j.earlhumdev.2012.12.002
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90105-p
更新日期:1992-02-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,多中心研究
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更新日期:1999-06-01 00:00:00
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journal_title:Early human development
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journal_title:Early human development
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2007.06.001
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0378-3782(95)01706-2
更新日期:1996-03-22 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.11.006
更新日期:2015-01-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2009.09.003
更新日期:2009-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01626-e
更新日期:1995-06-21 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章,评审
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更新日期:1998-12-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1998-07-10 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00