Abstract：
BACKGROUND:Retinopathy of prematurity (ROP) is often associated with visual impairment and multiple developmental disabilities. AIMS:As most of the previous studies include infants with brain lesions, that can determine visual impairment per se, a cohort of low neurological risk preterm infants without ROP and with various degree of severity of ROP was assessed in order to establish visual and neurodevelopmental outcome. STUDY DESIGN:Preterm infants born at <31 weeks gestation, without major brain lesions, underwent visual function assessment at 1 year corrected age and neurodevelopmental assessment at 2 years corrected age. SUBJECTS:One hundred and five infants were included in the study: 42 infants did not develop ROP, 7 reached stage 1 in zone 2 ROP, 37 reached prethreshold (untreated) type 2 ROP. The remaining 19 infants were classified as type 1 ROP. OUTCOME MEASURES:Visual function (including fixing, tracking, visual acuity, visual field, attention at distance and nystagmus) were assessed at 12 months corrected age and Griffiths Scales at 2 years corrected age. RESULTS:The severity of ROP was strongly correlated (p < 0.001) with both visual function at 1 year and neurodevelopment at 2 years. Similarly, the presence of nystagmus was also strongly correlated with visual and neurodevelopmental sequelae. CONCLUSIONS:Infants with no or milder retinopathy showed normal visual function at 1 year and neurodevelopment at 2 years. Infants who underwent treatment more frequently showed abnormal results on several aspects of visual function. Presence of nystagmus appeared to increase the risk for abnormal visual function and neurodevelopmental outcome.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Ricci D,Lucibello S,Orazi L,Gallini F,Staccioli S,Serrao F,Olivieri G,Quintiliani M,Sivo S,Rossi V,Leone D,Ferrantini G,Romeo DM,Frezza S,Amorelli GM,Molle F,Vento G,Lepore D,Mercuri Edoi
10.1016/j.earlhumdev.2020.105134subject
Has Abstractpub_date
2020-09-01 00:00:00pages
105134eissn
0378-3782issn
1872-6232pii
S0378-3782(20)30310-8journal_volume
148pub_type
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