Abstract：
BACKGROUND:Few studies describe in detail the pregnancy and early development of infants with Prader-Willi syndrome (PWS). However, variations at these early stages may partially account for differences in the later phenotype. A recent paper described an abnormally high number of problems in pregnancy and early infancy in a large sample of people with PWS but this sample was not homogeneous with respect to age and potentially liable to cohort effects. AIMS:To describe the early development of infants with PWS, younger and more homogeneous for age, and to investigate whether such high rates of perinatal problems are still present despite medical advances and whether there are differences according to the genetic subtypes. STUDY DESIGN:Using a structured interview, data were collected from mothers and from relevant GP and hospital records. SUBJECTS:Forty-six babies with PWS, born in a six-year period 2000-2006, and their mothers. OUTCOME MEASURES:Problems arising during pregnancy, the birth process and the neonatal period and the birth characteristics of the babies. RESULTS:An abnormally high number of problems associated with the early developmental period similar to those previously reported were observed. The only significant difference between the genetic subtypes was that mother's age was positively correlated with birth weight for UPD (and negatively correlated for deletion subtypes). CONCLUSIONS:High rates of, and variability in, the nature and severity of problems arising during early development have been confirmed. To establish whether variability in the later phenotype is influenced by such differences requires a longitudinal study.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Whittington JE,Butler JV,Holland AJdoi
10.1016/j.earlhumdev.2007.08.007subject
Has Abstractpub_date
2008-05-01 00:00:00pages
331-6issue
5eissn
0378-3782issn
1872-6232pii
S0378-3782(07)00156-9journal_volume
84pub_type
杂志文章abstract：BACKGROUND:In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of several brain areas, including the cerebellum and the hippocampus. The most plausible reason for reduction would be the reduced cell formation following premature birth. However, no ...
journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90152-5
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pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90112-9
更新日期：1984-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90028-2
更新日期：1983-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,实务指引,评审
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更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Early human development
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journal_title：Early human development
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journal_title：Early human development
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.10.001
更新日期：2013-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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