Abstract:
:Thrombocytopenia is a very frequent problem among sick neonates, affecting up to 35% of all infants admitted to the neonatal intensive care unit (NICU), and serves as an important indicator of multiple clinical conditions. The cause of the thrombocytopenia is unclear in up to 60% of affected neonates. A clinical classification of thrombocytopenia is based on the time of presentation, early (≤72 hours of life) vs. late (>72 hours of life). Early thrombocytopenia is commonly associated with feto-maternal conditions, is most commonly caused by disorders associated with placental insufficiency, and is generally mild to moderate and resolves spontaneously within 7-10 days without any intervention. In contrast, neonates who develop late-onset thrombocytopenia frequently have bacterial sepsis or necrotizing enterocolitis. It is often severe (platelets <50,000/μL), prolonged and frequently requires multiple platelet transfusions. Platelet transfusions represent the only specific therapy currently available for most thrombocytopenic neonates, even though much evidence suggests that platelet transfusions are not benign. Many of the prophylactic platelet transfusions currently given to NICU patients are unnecessary, convey no benefits, and carry known and unknown risks. For this reason, pharmacological alternatives have been investigated as potential therapies for thrombocytopenia, but they still have limited use treating the common varieties of neonatal thrombocytopenia.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Del Vecchio Adoi
10.1016/S0378-3782(14)50014-Xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
S51-5eissn
0378-3782issn
1872-6232pii
S0378-3782(14)50014-Xjournal_volume
90 Suppl 2pub_type
杂志文章,评审abstract::Screening preschool children for potential school problems may allow early intervention. Children beginning first grade (N=980) were tested with Denver II. All with normal/questionable results had satisfactory school performance while 26% of those with abnormal Denver II had low school scores. 43%, 27% and 0% of child...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.12.001
更新日期:2007-09-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.11.007
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abstract:BACKGROUND:The reported national case fatality rates (CFRs) for coronavirus disease 2019 (COVID-19) shows a sex bias with males > females. The relative lengths of the index (2D) and ring (4D) fingers (digit ratio; 2D:4D) is a sexually dimorphic (males < females) proxy of fetal sex steroids (low 2D:4D indicates high pre...
journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 评论,信件
doi:10.1016/j.earlhumdev.2010.09.372
更新日期:2011-01-01 00:00:00
abstract::Low birthweight has been associated with diseases and disorders later in life. It has been suggested that this is caused by the impaired development of abdominal organs, especially in cases of growth retardation. Besides general malnutrition of the fetus, preferential bloodflow to the heart and brain may further depri...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(97)00073-x
更新日期:1998-04-17 00:00:00
abstract::No statistically significant relationships were observed between the red blood cell acid phosphatase polymorphism (ACP-1) and birth weight, duration of gestation and proportion of preterm infants in a large series of newborn infants (greater than 8000) in Cardiff. These results are contrasted with those of a similar, ...
journal_title:Early human development
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::To learn if chemoreceptor control of breathing is abnormal in babies whose mothers took narcotics, cocaine, or both drugs during pregnancy, we performed hypoxia and hypercapnia challenges on 28 babies (greater than or equal to 36 weeks gestation). Six babies were exposed to narcotics, six to cocaine, nine to both drug...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90193-7
更新日期:1991-12-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(94)90150-3
更新日期:1994-05-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00063-8
更新日期:2000-03-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.07.006
更新日期:2013-10-01 00:00:00
abstract::Breast- and formula-fed infants were compared with regard to behavior patterns, especially crying behavior. A diary concerning seven behaviors was completed by 188 mothers of breast- and formula-fed infants at the well baby clinic. Breast-fed infants were fed more frequently with longer feeding duration. They slept mo...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(00)00071-2
更新日期:2000-05-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) is associated with altered lung development in human and rat. The transcription factor PPARγ, is thought to contribute to lung development. PPARγ is activated by docosahexanoic acid (DHA). One contribution of PPARγ to lung development may be its direct regulation of chromatin mod...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.08.026
更新日期:2010-12-01 00:00:00
abstract::Comparisons of the components of ventilator waveform were made in two groups of preterm infants ventilated for the respiratory distress syndrome. Infants actively expiring against positive pressure inflation were compared to infants not showing this interaction. The actively expiring infants were ventilated with a hig...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(88)80051-3
更新日期:1988-05-01 00:00:00
abstract::Behavioural state observations were carried out on 12 fetuses which subsequently had birthweights below the 10th percentile. Their gestational ages at the time of study ranged from 32 to 40 weeks. Real-time ultrasound scanning was used to detect fetal body and eye movements, and the fetal heart rate was continuously r...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90181-1
更新日期:1985-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90034-z
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Bright constant light levels in the NICU may have negative effects on the growth and development of preterm infants OBJECTIVE:The aim of this study is to evaluate the benefits of an alternating light/dark cycle in the NICU on weight gain and early discharge from the therapy in premature infants. PATIENTS A...
journal_title:Early human development
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2014.04.015
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Many women with a bipolar disorder are of reproductive age and will need to continue lithium treatment during pregnancy. The teratogenic and perinatal effects of lithium are known, but not the long-term effects of lithium on neurodevelopment of the children. This study investigates growth, neurological, co...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.09.013
更新日期:2012-06-01 00:00:00
abstract::Vascular tumours (haemangiomas and malformations) are common tumours of infancy and childhood. They represent a group of mostly benign conditions, which present early, can grow rapidly and be symptomatic or disfiguring. There are various management options, with different cosmetic and functional outcomes. Haemangiomas...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.08.017
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Kangaroo care, i.e., skin-to-skin cohabitation (SSC) between an infant and caregiver, is often used in neonatal intensive care units to promote bonding, breastfeeding and infant growth. The direct salutary effects of SSC on cardio-respiratory control in preterm infants remain equivocal; some reports suggest ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.08.015
更新日期:2014-12-01 00:00:00
abstract::CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosis and treatment of congenita...
journal_title:Early human development
pub_type: 杂志文章,实务指引
doi:10.1016/j.earlhumdev.2011.08.021
更新日期:2011-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.07.006
更新日期:2005-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.10.001
更新日期:2013-12-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.01.012
更新日期:2013-04-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(00)00079-7
更新日期:2000-06-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.10.008
更新日期:2012-06-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(14)70017-9
更新日期:2014-03-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90140-e
更新日期:1990-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.104970
更新日期:2020-05-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.01.013
更新日期:2006-11-01 00:00:00
abstract::Several studies have described an association between very preterm birth and behavioral and psychiatric outcomes in childhood and adolescence. The exact mechanisms underlying this association are unknown, but impaired neurodevelopment has been proposed as a possible etiological factor. Existing research suggests a sel...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.02.002
更新日期:2013-04-01 00:00:00