Abstract：
:805 normal-for-age human embryos and fetuses were used to study early prenatal fat development. The investigation included observations on stages of fat morphogenesis at the light microscopic level and computerized image analyses of fat lobule size and number. The buccal fat pad was selected as a model system for the analyses. Fat tissue differentiates between the 14th and the 16th weeks: there are five morphogenic phases in adipose tissue formation, strongly associated with the formation of blood vessels. Fat lobules are the earliest structures to be identified before typical vacuolated fat cells appear. Concerning fat lobule size and number, we show that after the 23rd week the total number of fat lobules remains approximately constant, while from the 23rd to 29th week the growth of adipose tissue is determined mainly by an increase in size of the lobules. These results suggest that the 14th through the 23rd week is a sensitive period in fat lobule development, and that disturbances of normal adipogenesis during this period may play a role in the etiology of obesity in later life.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Poissonnet CM,Burdi AR,Bookstein FLdoi
10.1016/0378-3782(83)90028-2subject
Has Abstractpub_date
1983-03-01 00:00:00pages
1-11issue
1eissn
0378-3782issn
1872-6232pii
0378-3782(83)90028-2journal_volume
8pub_type
杂志文章abstract：:To determine the assessments before discharge from the intensive care unit, that will predict outcome most accurately, a prospective longitudinal study in a cohort of 79 high risk VLBW children was conducted from birth to 3.6 years of age. Birthweight, gestational age, obstetrical and neonatal optimality, neonatal neu...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90040-n
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:The reported national case fatality rates (CFRs) for coronavirus disease 2019 (COVID-19) shows a sex bias with males > females. The relative lengths of the index (2D) and ring (4D) fingers (digit ratio; 2D:4D) is a sexually dimorphic (males < females) proxy of fetal sex steroids (low 2D:4D indicates high pre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105074
更新日期：2020-07-01 00:00:00
abstract：:A method has been developed for long-term continuous recordings of several physiological variables in humans, including body movements, core temperature, heart rate and respiratory rate. This method enabled us to study circadian rhythms of body temperature and rest-activity in preterm infants. In 5 out of 9 infants (r...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90137-8
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Visual cognitive functions of preverbal infants are evaluated by means of a behavioral assessment. Parents or primary caregivers may be appropriate to certify the acquisition of certain abilities. AIMS:To develop the PreViAs (Preverbal Visual Assessment) questionnaire to assess visual behavior of infants un...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.01.012
更新日期：2014-04-01 00:00:00
abstract：:In the last two decades the survival of extreme preterm infants and sick newborn infants has improved significantly due to the advances in perinatal medicine. Despite this advance, for some babies, withholding or withdrawal of life sustaining treatment may be the best option in the interest of the baby. An overview of...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.01.002
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Cognitive, behavioral, and learning problems are evident in extremely preterm/extremely low birth weight (EPT/ELBW, <28 weeks gestational age or <1000 g) children by early school age. However, we know little about how they function within the classroom once they start school. AIMS:To determine how EPT/ELBW ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.09.011
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To assess the applicability of Drotar model when the diagnosis of congenital malformation is made antenatally. METHODS:In a 3-year period (2000-2003) fifty mothers, counselled for fetal malformations amenable to surgical correction at birth, were interviewed. Statistical associations were sought between each...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.12.010
更新日期：2006-10-01 00:00:00
abstract：:Vascular tumours (haemangiomas and malformations) are common tumours of infancy and childhood. They represent a group of mostly benign conditions, which present early, can grow rapidly and be symptomatic or disfiguring. There are various management options, with different cosmetic and functional outcomes. Haemangiomas...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.08.017
更新日期：2010-10-01 00:00:00
abstract：:The objective of this work was to examine the changes in the fatty acid profiles of plasma lipid fractions and red blood cell membrane phospholipids in newborn infants during the first 6-8 h of life. Methyl esters of fatty acids from plasma free fatty acids and phospholipids and from membrane phosphatidylethanolamine,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(87)90041-7
更新日期：1987-03-01 00:00:00
abstract：:We have investigated 20 healthy full-term newborns between the 4th and the 6th day of life in standard conditions for laterality of arm movements, before and after introduction of a target. The durations of recording were: (a) 5 min continuously before target introduction; (b) five 1-min units during target presentati...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90099-6
更新日期：1989-04-01 00:00:00
abstract：:Pulse oximetry screening is a highly specific, moderately sensitive test for detecting critical congenital heart defects (CCHDs) that meets the criteria for universal screening. The possibility of using pulse oximetry as a screening test was first investigated over 10 years ago and since then data from more than 370,0...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(14)50006-0
更新日期：2014-09-01 00:00:00
abstract：:Whether preeclampsia affects the fetal hematologic system still remains a controversial issue. The purpose of this series was to examine the hypothesis that preeclampsia may or may not cause adverse effects on fetal hemogram, including erythrocytes, leukocytes, and platelets. In addition, no one, to date, has reported...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90150-3
更新日期：1994-05-01 00:00:00
abstract：:Stress due to earthquakes and other natural catastrophic events may result in a decline in the male to female ratio of newborn infants. One reason may be an increased death of male fetuses 3-5 months earlier. Another reason may relate to reduced conception of males and/or early male embryo demise 8-10 months earlier. ...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2019.104859
更新日期：2020-01-01 00:00:00
abstract：:This study examined the risk factors for respiratory distress syndrome (RDS) in preterm infants from pregnancies complicated by placenta previa. Forty preterm infants born to mothers with placenta previa between January 1989 and December 1995 in a medical center were enrolled. Each of these patients was matched in ges...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00121-3
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Evaluation of cerebellar morphology and measurement of its biometric parameters such as cerebellar vermis height and transverse cerebellar diameter may assist the neonatologist in monitoring cerebellar growth and development and detect abnormalities resulting from malformations, hemorrhage or ischemic infarc...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.10.001
更新日期：2013-12-01 00:00:00
abstract：UNLABELLED:During the previous two decades smoking among pregnant women in the developed world declined by about 60-75%. Nevertheless, prenatal smoking remains a common habit and accounts for a significant proportion of fetal morbidity and mortality through both a direct (fetal) and an indirect (placental) effect. The ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2007.08.002
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Preterm birth is a known risk factor for infant development but it is less clear whether fetal growth restriction (FGR) and early term birth between 37 and 39 weeks gestation are associated with risks for infant development. AIMS:This study investigated risk factors for adverse developmental outcomes at 12 ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.104951
更新日期：2020-03-01 00:00:00
abstract：:To learn if chemoreceptor control of breathing is abnormal in babies whose mothers took narcotics, cocaine, or both drugs during pregnancy, we performed hypoxia and hypercapnia challenges on 28 babies (greater than or equal to 36 weeks gestation). Six babies were exposed to narcotics, six to cocaine, nine to both drug...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90193-7
更新日期：1991-12-01 00:00:00
abstract：:Bakan's hypothesis that sinistrality is caused by perinatal insult was investigated by attempting to relate the handedness of 1094 six-year-old children to many aspects of their birth history ascertained from hospital records. Handedness of the children and their families was obtained by questionnaire. A secular incre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(80)90011-0
更新日期：1980-03-01 00:00:00
abstract：:Cerebral blood flow velocity (CBFV) was measured using Doppler ultrasound on the first day of life in a consecutively admitted cohort of 52 very low birthweight infants. Recordings were made for a period of 1 min. The coefficient of variation for the area under the curve of 20 successive cardiac cycles was calculated,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(96)01769-0
更新日期：1997-01-03 00:00:00
abstract：BACKGROUND:Patent ductus arteriosus (PDA) is a frequent problem in preterm infants, and its incidence is inversely correlated with gestational age. The efficacy of medical treatment decreases with decreasing gestational age (GA), and failure rates as well as ductus ligation rates of 40% have been reported in <28 week G...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.06.012
更新日期：2010-08-01 00:00:00
abstract：:The relationship between blood glucose and body physique of 233 (42 hypo-and 191 normologycemic) intrauterine growth-retarded neonates was analyzed using different body measurements and indices of body proportions. Classification by combination of weight and length deficit for fetal age revealed that the disproportion...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(77)90027-5
更新日期：1977-10-01 00:00:00
abstract：:Dramatic improvements have occurred in the overall health of our children driven by rigorous research translated into clinical practice. However, all is not well for too many, not only for their health but for other outcomes of their lives. These outcomes reflect poorly on how professional groups in child life and hea...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2014.08.022
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Previous studies using ultrasound technology showed that fetal heart rate (HR) may be responsive to maternal aerobic exercise. Although it is recognized that cardiac autonomic control may be influenced by the intrauterine environment, little is known about how maternal exercise affects fetal heart developmen...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.03.002
更新日期：2010-04-01 00:00:00
abstract：:The calculation of descriptive statistics includes the calculation of standard error and confidence interval, an inevitable component of data analysis in inferential statistics. This paper provides pointers as to how to do this in Microsoft Excel™. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.01.013
更新日期：2018-03-01 00:00:00
abstract：:Pregnancy is characterized by physiological, endocrine and metabolic adaptations creating a pseudo-diabetogenic state of progressive insulin resistance. These adaptations occur to sustain continuous fetal requirements for nutrients and oxygen. Insulin resistance develops at the level of the skeletal muscle, and matern...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2016.01.008
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the newborn transient evoked otoacoustic emission (TEOAE) hearing screening tests of infants later diagnosed with the sudden infant death syndrome (SIDS). STUDY DESIGN:In a case-controlled study, the newborn TEOAE hearing screens of 31 infants who subsequently died of SIDS were retrospectively co...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.06.001
更新日期：2008-04-01 00:00:00
abstract：:The objectives of this study were (1) to detect vasoactive intestinal polypeptide in fetal blood obtained by cordocentesis (2) to examine possible changes in growth retarded fetuses and to establish relationships between its levels and fetal blood acid-base status as well as fetal haemodynamics as assessed by Doppler ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)01610-2
更新日期：1995-03-17 00:00:00
abstract：BACKGROUND:The kidney is one organ which presents distinct morphology depending on GA; the classic references for kidney measurements were established several years ago and it is not certain if they are still accurate. AIM:To evaluate the renal maturity using a computer-assisted morphometry in autopsied fetuses within...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.01.013
更新日期：2006-11-01 00:00:00
abstract：:This year is the 20th anniversary of the first successful trial of exogenous surfactant for respiratory distress syndrome in the newborn and it is perhaps a good time to review recent advances in basic science and clinical practice as they relate to surfactant therapy. ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/s0378-3782(00)00122-5
更新日期：2001-03-01 00:00:00
