Abstract：
:To learn if chemoreceptor control of breathing is abnormal in babies whose mothers took narcotics, cocaine, or both drugs during pregnancy, we performed hypoxia and hypercapnia challenges on 28 babies (greater than or equal to 36 weeks gestation). Six babies were exposed to narcotics, six to cocaine, nine to both drugs, and seven babies were controls. Studies were done at 3 and 8 weeks and 3 and 5 months of age. Gestational ages were similar, but birth weight was lower in the cocaine group. Respiratory rate was higher in both groups of cocaine-exposed babies at 3 weeks. End-tidal partial pressure of CO2 (PCO2) was decreased and partial pressure of O2 (PO2) increased at 3 and 8 weeks in babies exposed to narcotics plus cocaine. At 3 weeks, babies exposed to narcotics plus cocaine had a shift to the left in CO2 response with a normal slope; at 8 weeks, both intercept and slope were decreased. Responses to hypoxia were similar among the four groups. Babies exposed to narcotics plus cocaine before birth have abnormalities in control of breathing in the first months after birth.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
McCann EM,Lewis Kdoi
10.1016/0378-3782(91)90193-7subject
Has Abstractpub_date
1991-12-01 00:00:00pages
175-186issue
3eissn
0378-3782issn
1872-6232pii
0378-3782(91)90193-7journal_volume
27pub_type
杂志文章abstract：BACKGROUND:Studies on motor performance and its early markers are rare in China, especially in very low birth weight (VLBW) infants. OBJECTIVE:Apart from the assessment of the inter-scorer agreement, we aimed to analyze to what extent the motor repertoire at 10 to 18weeks postterm was related to neonatal complications...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.03.010
更新日期：2016-09-01 00:00:00
abstract：:In the scholarly environment, research findings are disseminated as journal papers which support/dispute extant knowledge or add further to what is already known. The entire manuscript needs to be cited (in-text) and referenced (at the end of article), in order for readers to ascertain the validity of the research cla...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.09.012
更新日期：2019-01-01 00:00:00
abstract：:Interest in determining the quality of life of children and adults is now considered a priority. This is a result of a shift in thinking with greater transparency in finding out not only the health outcomes, but also the personal burden of illness and life satisfaction for the individual. However, there is still no co...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.01.012
更新日期：2013-04-01 00:00:00
abstract：:Lenticulostriate vasculopathy (LSV) is a diagnosis dependent on neonatal cranial ultrasound (US). The diagnosis of LSV requires the presence of linear or branching echogenicities in the area of the basal ganglia and/or thalamus on gray scale cranial US. Although the diagnosis of LSV is dependent on cranial US, there a...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2015.04.003
更新日期：2015-07-01 00:00:00
abstract：AIMS:The aim of the current study was to developed and test the reliability of a technique for measuring temporal parameters of sucking in breastfeeding infants. METHODS:The technique was developed using a cohort of 11 term and 12 preterm infants, and subsequently evaluated using a cohort of 43 preterm infants. Measur...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.04.008
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Natural cell death due to apoptotic mechanisms has been described in various species. Relatively few studies examined this process in humans. AIM:To investigate the distribution of apoptosis in fetal brain tissue. DESIGN:We examined apoptosis in the frontal region of human fetal brain by the TUNEL method i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(02)00116-0
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Preterm children have problems with mathematics but knowledge about the predictors of specific mathematic abilities in preterm populations is scarce. AIMS:This study investigated neurodevelopmental pathways to children's general and specific mathematic abilities across the full gestational age range. STUDY...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.07.015
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The requirement of essential fatty acids (EFA) for the development of the brain is well documented. OBJECTIVE:To investigate the early neurological development at term and 44 weeks gestational age in preterm infants in relation to EFA concentrations in breast milk and in infants' and mothers' plasma phospho...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.05.017
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Infants whose mothers had low serum pregnancy-associated plasma protein-A (PAPP-A) in the first trimester were observed to have intrauterine growth retardation. AIM:Suggesting that PAPP-A plays an important role in the availability and activity of insulin-like growth factors (IGFs), which affect growth, we ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.10.005
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:The long-term effect of early intervention in infants at risk for developmental disorders is unclear. The VIP project (n=46, originally) evaluated by means of a randomised controlled trial the effect of the family centred early intervention programme COPCA (Coping with and Caring for infants with special nee...
journal_title：Early human development
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.earlhumdev.2017.02.002
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:Extremely low birth weight (ELBW; <1kg) adolescents are at risk for special health care needs (SHCN) and poor math achievement compared to normal birth weight (NBW) peers. SHCN are associated with poor academic achievement among NBW children. We hypothesize that SHCN explain the effect of ELBW on math achiev...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2017.09.019
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Maternal pre-pregnancy overweight is known to program offspring for adverse health outcomes later in life. AIMS:To investigate how growth patterns of weight, height and BMI from birth to 7years differ according to maternal pre-pregnancy weight (normal weight, overweight and obesity), with specific attention...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2017.06.002
更新日期：2017-10-01 00:00:00
abstract：:This study examined the risk factors for respiratory distress syndrome (RDS) in preterm infants from pregnancies complicated by placenta previa. Forty preterm infants born to mothers with placenta previa between January 1989 and December 1995 in a medical center were enrolled. Each of these patients was matched in ges...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00121-3
更新日期：2001-01-01 00:00:00
abstract：:The prone sleeping position has been identified in world-wide epidemiological studies as a major risk factor for sudden infant death syndrome (SIDS). Public awareness campaigns throughout the western world have led to an over 50% reduction in postneonatal mortality and frequency of SIDS. This reduction in mortality ha...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/s0378-3782(02)00025-7
更新日期：2002-10-01 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
abstract：UNLABELLED:While the role of antiepileptic drug (AED) therapy in teratogenesis has widely been investigated, there are few prospective studies on later postnatal development in offspring of epileptic women in utero exposed. The aim of this study was a prospective investigation of the psychomotor development in a select...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(03)00083-5
更新日期：2003-11-01 00:00:00
abstract：UNLABELLED:The aim of the study was to determine the effect of a low oral dose of erythromycin on whole gastrointestinal transit time [WGTT]. Erythromycin [EM] [1.5 mg/kg, 6 hourly] or placebo was given first over 7 days in a double blind randomized crossover study of 21 preterm infants with feed intolerance. Median [r...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-3782(01)00191-8
更新日期：2001-12-01 00:00:00
abstract：PURPOSE:Maternal nutritional status is one of the most important factors of fetal growth and development. Consequently, the currently increasing prevalence of underweight women worldwide has come in the focus of interest of perinatal medicine. The aim of the study was to assess the effect of low pre-pregnancy body mass...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.10.004
更新日期：2013-05-01 00:00:00
abstract：:Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90178-w
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVE:We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. STUDY DESIGN:174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.104970
更新日期：2020-05-01 00:00:00
abstract：:To investigate the influence of prematurity and postnatal age on the maturation of the autonomic nervous system function, we analysed heart-rate and heart-rate variability in twelve prematurely born infants (< 37 weeks gestational age) reaching the conceptional age of 37-41 weeks. These neonates were compared with six...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90011-i
更新日期：1993-03-01 00:00:00
abstract：:Posture and spontaneous motor patterns during the first days of life were studied in ten healthy fullterm infants by direct observation and videorecording. The aim of the study was to provide a description of motor and postural characteristics of normal newborns. The infants were recorded for 1 h on their first and fo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90020-0
更新日期：1989-02-01 00:00:00
abstract：:We have investigated infant-caregiver interactions in an isolated African subsistence farming community where women perform arduous agricultural tasks in addition to their normal domestic duties which include child care. 49 babies aged 3-18 months were studied on one or two occasions. Detailed observations were made o...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90139-2
更新日期：1985-10-01 00:00:00
abstract：:A new protocol for structured observation of motor performance in infants, SOMP-I, was applied to 72 neonatally healthy fullterm infants at 0, 2, 4, 6 and 10 months of age. It contains 13 items, formed as ascending scales, consisting of detailed descriptions of motor performance in different body positions and body pa...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)01598-J
更新日期：1995-01-30 00:00:00
abstract：:As major sport events have been cancelled and postponed in response to COVID-19, the necessity to protect and provide a holistic approach to the professional athlete has never been greater. To do so one must understand the negative consequences for athletes in relation to the cancellation and postponement of such even...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105254
更新日期：2020-11-12 00:00:00
abstract：:Doctors are frequently depicted as important protagonists in science fiction, including in the science fiction franchise Star Trek. This paper will profile Drs. Philip Boyce and Mark Piper from the first two Star Trek pilot episodes. These doctors are interdisciplinarians with a variety of skills that permit them to c...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2020.104988
更新日期：2020-05-01 00:00:00
abstract：:Among 7 subjects with hyperemesis gravidarum (HG), we found gabapentin therapy to be associated with mean reductions in nausea and emesis from Baseline to Days 12-14 of 80% and 94%, respectively. There have been 2 congenital defects among 7 exposed infants. Gabapentin may be effective in the treatment of HG. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2009.11.003
更新日期：2010-01-01 00:00:00
abstract：:Maternal milk four days post partum contained immunoreactive calcitonin in concentrations which were 22-89 times higher than those noted in concomitantly sampled maternal sera. Neurotensin-like immunoreactivity was barely detectable in milk. It is suggested that calcitonin may be a prerequisite for the concentration o...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90060-3
更新日期：1982-01-01 00:00:00
abstract：:Measurement of methionine levels in dried blood spots has been one of the items of neonatal screening in Taiwan for more than 20 years. In 1,701,591 newborns, 17 cases of hypermethioninemia were detected, but among them only one had homocystinuria. More than half of the 16 cases of isolated hypermethioninemia had muta...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.11.005
更新日期：2005-06-01 00:00:00
abstract：:Modifications of brain-stem acoustic evoked potentials (BAEPs) in the first 5 days of life of normal full-term infants are reported. BAEPs were recorded using rarefaction clicks at 70, 60, 40, 20 dB HL. Multiple linear regression analysis was performed to evaluate chronological and gestational age differences for all ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90034-z
更新日期：1991-11-01 00:00:00
