Abstract:
:Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery were not related to maternal serum albumin levels at 18 or 30 weeks' gestational age. The degree of maternal obesity significantly correlated with the concentration of albumin. There was a significant negative correlation in individual women between maternal serum levels of albumin and alpha-fetoprotein, with high levels of maternal serum alpha-fetoprotein predicting lower levels of albumin. We hypothesize that there may be a negative feedback effect of alpha-fetoprotein of fetal origin on the maternal production of albumin during pregnancy.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Maher JE,Goldenberg RL,Tamura T,Cliver SP,Hoffman HJ,Davis RO,Boots Ldoi
10.1016/0378-3782(93)90178-wsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
209-15issue
3eissn
0378-3782issn
1872-6232pii
0378-3782(93)90178-Wjournal_volume
34pub_type
杂志文章abstract:BACKGROUND:The assessment of the quality of general movements (GMs) in young infants is a reliable and valid diagnostic tool for detecting brain dysfunction early in life. Of special interest is a type of GMs called fidgety movements (FMs) characteristic for 3- to 5-month-old infants. GMs are part of an infant's sponta...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.01.004
更新日期:2004-04-01 00:00:00
abstract::To determine the assessments before discharge from the intensive care unit, that will predict outcome most accurately, a prospective longitudinal study in a cohort of 79 high risk VLBW children was conducted from birth to 3.6 years of age. Birthweight, gestational age, obstetrical and neonatal optimality, neonatal neu...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90040-n
更新日期:1992-12-01 00:00:00
abstract::The magnitude of inflating pressure necessary for effective resuscitation was examined in 70 preterm infants. The median pressure to cause adequate chest wall expansion was 22.8 cmH2O; no infant required a peak inflating pressure greater than 30 cmH2O. No further increase in inflation pressure was used during resuscit...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90045-5
更新日期:1991-07-01 00:00:00
abstract::The Golgi-Cox method was used to study the maturation of the large pyramidal cells of the Vth cortical layer in three groups of adult rats: one subjected to undernutrition during the first month of life, another throughout the first 2 mth of life, and the last one during gestation and the suckling period. The main alt...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(86)90186-6
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is a leading cause of hospitalization for children <1year old and is more severe in premature infants. OBJECTIVE:To assess whether late preterm (LPT) birth is an independent risk factor for RSV hospitalization and more severe RSV disease in children less than 24months old. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.06.009
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:There is a lack of standardized echocardiographic parameters to quantify ventricular function in newborn infants. Long-axis systolic ventricular shortening is a useful parameter of global ventricular function. AIMS:Serial assessment of long-axis systolic atrioventricular annulus excursion in premature infan...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.09.006
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The second-to-fourth digit ratio (2D:4D) reflects prenatal estrogen and testosterone exposure, and is established in utero. Sex steroids are implicated in development and progression of primary brain tumors. AIMS:To investigate whether there is a link between 2D:4D ratio and primary brain tumors, and age at...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.10.003
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:This pilot study compared the physiological and behavioural changes in premature infants undergoing three different methods of screening for retinopathy of prematurity (ROP). STUDY DESIGN:Prospective randomized cross-over pilot study. SUBJECTS AND METHODS:Fifteen premature infants requiring screening for ROP ...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2004.09.005
更新日期:2005-04-01 00:00:00
abstract::White matter injury and abnormal maturation are thought to be major contributors to the neurodevelopmental disabilities observed in children and adolescents who were born preterm. Early detection of abnormal white matter maturation is important in the design of preventive, protective, and rehabilitative strategies for...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2008.09.004
更新日期:2008-12-01 00:00:00
abstract::A new protocol for Structured Observation of Motor Performance in Infants, SOMP-I, designed to describe both progress and quality of motor performance, was evaluated concerning its ability to describe and to discriminate between the motor performance observed in different groups of infants. Sixty-eight infants born at...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01678-3
更新日期:1995-11-24 00:00:00
abstract::The objective of this work was to examine the changes in the fatty acid profiles of plasma lipid fractions and red blood cell membrane phospholipids in newborn infants during the first 6-8 h of life. Methyl esters of fatty acids from plasma free fatty acids and phospholipids and from membrane phosphatidylethanolamine,...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(87)90041-7
更新日期:1987-03-01 00:00:00
abstract::Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00077-2
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:We evaluated the effect of maternal administration of betamethasone (0.2 mg/kg per day) on mitogen-induced lymphocyte proliferation and interleukin-2 (IL-2) production by maternal, fetal, and neonatal rat splenic lymphocytes. STUDY DESIGN:Betamethasone was injected intramuscularly on days 19 and 20 of gestat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(94)90028-0
更新日期:1994-01-01 00:00:00
abstract::Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(83)90068-3
更新日期:1983-07-01 00:00:00
abstract::Lipids have physical, chemical, and physiological properties that make them important factors in human nutrition. They form a group of compounds of varied chemical nature that have the common property of being soluble in organic solvents but insoluble in water. This basic property affects their digestion, absorption, ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/s0378-3782(01)00211-0
更新日期:2001-11-01 00:00:00
abstract::The relationship between cyclic 3',5'-adenosine monophosphate (cAMP) excretion and creatinine clearance, urinary phosphate excretion, and urinary osmolarity was studied under basal conditions in 29 babies of 28-40 weeks gestation, during the first few days of life. Urinary cAMP excretion was directly related to creati...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(84)90112-9
更新日期:1984-09-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is one of the most important sequelae of premature birth and the most common form of chronic lung disease of infancy. From a clinical standpoint BPD subjects are characterized by recurrent respiratory symptoms, which are very frequent during the first years of life and, although becomi...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.07.015
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether maternal obesity poses a risk for long-term cardiovascular morbidity in the offspring. STUDY DESIGN:Data were analyzed from a non-selective population of all infants born between the years 1991-2014 at the tertiary Soroka University Medical Center (SUMC), the sole hospital in the south...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105221
更新日期:2020-12-01 00:00:00
abstract::Modifications of brain-stem acoustic evoked potentials (BAEPs) in the first 5 days of life of normal full-term infants are reported. BAEPs were recorded using rarefaction clicks at 70, 60, 40, 20 dB HL. Multiple linear regression analysis was performed to evaluate chronological and gestational age differences for all ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90034-z
更新日期:1991-11-01 00:00:00
abstract::Surfactant is now available for general clinical use in infants with RDS. While surfactant is effective, it does not prevent lung disease in many preterm infants because of other aspects of lung immaturity. In experimental models, corticosteroids alter the fetal lung by improving compliances, increasing lung volumes, ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(92)90058-o
更新日期:1992-06-01 00:00:00
abstract::We measured plasma and erythrocyte vitamin E (VE) and plasma vitamin A (VA) profiles in 48 full-term and 8 preterm pairs of neonates and their mothers at birth and we determined whether there is any relationship between maternal and umbilical cord for the nutrients measured. At the same time, we assessed the influence...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00070-x
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:A short course of moderately early dexamethasone therapy with a starting dose of 0.5 mg/kg/day improves lung compliance and shortens the duration of ventilatory support in preterm infants with respiratory distress syndrome (RDS). We conducted a double-blind, randomized study to evaluate whether a moderately e...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-3782(03)00082-3
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Gastroschisis and omphalocele are the most common anterior abdominal wall defects affecting infants. There are few large cohort studies describing the frequency of associated anomalies in infants with these 2 conditions. We describe associated anomalies and outcomes in infants with these defects using a larg...
journal_title:Early human development
pub_type: 杂志文章,多中心研究
doi:10.1016/j.earlhumdev.2014.05.006
更新日期:2014-08-01 00:00:00
abstract::The reactions of heart rate (HR), systolic (sBP) and diastolic (dBP) blood pressure were studied in response to passive head-up tilting (successively to +45 degrees and +90 degrees) in a group of 83 full-term, 1- to 7-day-old newborns who were quiet and awake. A significant mean increase of HR was noted for the whole ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01706-2
更新日期:1996-03-22 00:00:00
abstract:OBJECTIVE:To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS:Eighty-one preterm infants b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2017.12.008
更新日期:2018-02-01 00:00:00
abstract::Prior research in newborns has shown that head-up and head-down tilting elicits sustained increases and decreases in heart rate, respectively. Other studies in older infants have suggested that the pattern of heart rate responses to head-up tilting varies with risk for sudden infant death syndrome (SIDS). In this stud...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00026-2
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of several brain areas, including the cerebellum and the hippocampus. The most plausible reason for reduction would be the reduced cell formation following premature birth. However, no ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.03.004
更新日期:2004-06-01 00:00:00
abstract::Twenty-seven 5--8-day-old babies were filmed during normal breast feeding (one feed each). Sucking patterns were determined from the film from a total sample of 17,676 sucks. Intersuck interals fell on two distributions: one of intervals between sucks during bursts of sucking (1.3 sec and less), and the other of rests...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(79)90042-2
更新日期:1979-12-01 00:00:00
abstract:OBJECTIVE:We hypothesized that morphine has a depressing effect on early brain activity, assessed using quantitative aEEG/EEG parameter and depressed activity will be associated with brain volumes at term in extremely preterm infants. STUDY DESIGN:174 preterm infants were enrolled in 3 European tertiary NICUs (mean GA...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.104970
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Maternal nutritional status is one of the most important factors of fetal growth and development. Consequently, the currently increasing prevalence of underweight women worldwide has come in the focus of interest of perinatal medicine. The aim of the study was to assess the effect of low pre-pregnancy body mass...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.10.004
更新日期:2013-05-01 00:00:00