Abstract:
BACKGROUND:The second-to-fourth digit ratio (2D:4D) reflects prenatal estrogen and testosterone exposure, and is established in utero. Sex steroids are implicated in development and progression of primary brain tumors. AIMS:To investigate whether there is a link between 2D:4D ratio and primary brain tumors, and age at presentation. METHODS:Digital images of the right and left palms of 85 primary brain tumor patients (age 56.96±13.68years; 71% women) and 106 (age 54.31±13.68years; 68% women) gender and age matched controls were obtained. The most common brain tumor diagnoses were meningioma (41%), glioblastoma (20%) and pituitary adenoma (16%). Right and left 2D:4D ratios, and right minus left 2D:4D (Dr-l) were compared between patients and controls, and were correlated with age. RESULTS:Right and left 2D:4D ratios were significantly lower in primary brain tumor patients relative to controls (t=-4.28, p<0.001 and t=-3.69, p<0.001, respectively). The Dr-l was not different between brain tumor patients and controls (p=0.27). In meningioma and glioma patients, age at presentation correlated negatively with left 2D:4D ratio (rho=-0.42, p=0.01 and rho=-0.36, p=0.02, respectively) and positively with Dr-l (rho=0.45, p=0.009 and rho=0.65, p=0.04, respectively). CONCLUSIONS:Right and left hand 2D:4D ratios are lower in primary brain tumor patients relative to healthy individuals suggesting greater prenatal testosterone and lower prenatal estrogen exposure in brain tumor patients. Greater age at presentation is associated with greater Dr-l and with lower left 2D:4D ratio of meningioma and glioma patients. Due to small sample size our results should be considered preliminary and interpreted with caution.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Bunevicius A,Tamasauskas S,Deltuva VP,Tamasauskas A,Sliauzys A,Bunevicius Rdoi
10.1016/j.earlhumdev.2016.10.003subject
Has Abstractpub_date
2016-12-01 00:00:00pages
205-208eissn
0378-3782issn
1872-6232pii
S0378-3782(16)30261-4journal_volume
103pub_type
杂志文章abstract::The evolution of ultrasound findings in 59 infants with transient periventricular densities is described and the neurodevelopmental outcome of 53 of these infants was compared with 92 of 107 infants with normal ultrasound scans, born during the same 24-month period. Four of the 53 infants with transient periventricula...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(88)90103-x
更新日期:1988-03-01 00:00:00
abstract::Newborn infants, especially preterm infants, have an immature immune system, which is not capable to actively protect against vaccine-preventable infections. Therefore, the newborn is dependent on transplacental transport of Immunoglobulin G (IgG), an active, FcRn receptor mediated process. Fetal IgG rises from approx...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2010.11.003
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Studies on motor performance and its early markers are rare in China, especially in very low birth weight (VLBW) infants. OBJECTIVE:Apart from the assessment of the inter-scorer agreement, we aimed to analyze to what extent the motor repertoire at 10 to 18weeks postterm was related to neonatal complications...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.03.010
更新日期:2016-09-01 00:00:00
abstract::Ninety five placentae from normal term and 'normal' preterm pregnancies have been analysed by morphometry. The growth of the whole placenta, of the microscopic placental constituents and of the villous surface area has been measured in placentae from uncomplicated pregnancies from 10 weeks of gestation to term to prov...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(84)90074-4
更新日期:1984-06-01 00:00:00
abstract::In this study of 167 neonates who demonstrated a total of 1010 transitions between arousal states, we considered whether specific state transitions were associated with umbilical cord blood lead levels. We found that the arousal patterns of neonates with varying levels (<1, 1-10 and >10 microg/dL) of lead exposure cou...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2007.06.002
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:The kidney is one organ which presents distinct morphology depending on GA; the classic references for kidney measurements were established several years ago and it is not certain if they are still accurate. AIM:To evaluate the renal maturity using a computer-assisted morphometry in autopsied fetuses within...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.01.013
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:There have been few research studies aimed at obtaining a better understanding of the prediction of subsequent respiratory morbidity at follow-up in infants with a previous history of bronchopulmonary dysplasia (BPD) living in low- and middle-income countries (LMIC). The aim of the present study was to ident...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2018.10.003
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Evaluation of cerebellar morphology and measurement of its biometric parameters such as cerebellar vermis height and transverse cerebellar diameter may assist the neonatologist in monitoring cerebellar growth and development and detect abnormalities resulting from malformations, hemorrhage or ischemic infarc...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.10.001
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of several brain areas, including the cerebellum and the hippocampus. The most plausible reason for reduction would be the reduced cell formation following premature birth. However, no ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.03.004
更新日期:2004-06-01 00:00:00
abstract::The purpose of this study was to investigate prostanoid synthesis in different segments of the umbilicoplacental vascular tree and its relationship to impaired maternal glucose tolerance. Segments from the umbilical artery and vein, allantochorionic artery branches, and the cotyledon artery from 21 women with diabetes...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3732(97)00036-2
更新日期:1998-01-09 00:00:00
abstract:BACKGROUND:Neonatal Encephalopathy (NE) is a prominent cause of infant mortality and neurodevelopmental disability. Hypothermia is an effective neuroprotective therapy for newborns with encephalopathy. Post-hypothermia functional-anatomical correlation between neonatal neurobehavioral abnormalities and brain injury fin...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.05.006
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Preterm newborns have low vitamin A reserves at birth, which increases their risk of morbidity and mortality. In the absence of supplementation, breast milk is the only source of this nutrient for exclusively breastfed infants. AIMS:To assess retinol concentration in preterm milk and the relationship betwee...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2017.01.006
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Several studies report increased minor neurodevelopment dysfunctions in children born very low birth weight (VLBW). Usefulness of preventive early intervention programs to improve neurodevelopment outcome of VLBW infants is still under investigation. AIMS:To evaluate the effects of an early post-discharge d...
journal_title:Early human development
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2006.01.011
更新日期:2006-10-01 00:00:00
abstract::This project aimed to assess the accuracy of Tempa-DOT and FeverScan for measuring children's temperatures. Tempa-DOT is a small flat chemical thermometer with 50 dots that change colour at specific temperatures. FeverScan is a liquid crystal strip thermometer with temperature sensitive colour bars that change colour ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00050-4
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:The importance of an infant's intra-oral vacuum in milk removal from the breast has been established. However, the relationship between the vacuum curve and milk transfer is not well understood. AIMS:To investigate the parameters of the infant suck cycle in relation to the volume of milk removed from the br...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.02.003
更新日期:2016-05-01 00:00:00
abstract::The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblasti...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.04.010
更新日期:2004-08-01 00:00:00
abstract::The potential use of a piglet as a model for investigation of brain blood flow was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn piglets. Blood pressure was altered by phlebotomy. When the mean arterial blood pressure was greater than 50 mm Hg, no significant change in bra...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90063-9
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Fluconazole prophylaxis has demonstrated efficacy in single and multicenter randomized controlled trials without side effects or emergence of resistance. Additional evidence based on incidence of invasive Candida infections, multicenter data, resistance, and safety is desired. METHODS:We conducted a case-co...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0378-3782(14)70026-X
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.06.006
更新日期:2011-12-01 00:00:00
abstract::The calculation of descriptive statistics after data collection provides researchers with an overview of the shape and nature of their datasets, along with basic descriptors, and may help identify true or incorrect outlier values. This exercise should always precede inferential statistics, when possible. This paper pr...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2018.02.015
更新日期:2018-03-01 00:00:00
abstract::A proportion of symptomatic neonates with congenital heart disease have lesions requiring urgent stabilisation. Despite increasing antenatal diagnoses, the importance of early recognition of symptomatic neonates is highlighted by the fact that up to 10% of all deaths in congenital heart disease continue to occur in ch...
journal_title:Early human development
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.earlhumdev.2008.01.011
更新日期:2008-03-01 00:00:00
abstract::In 1% of monozygotic twin pregnancies, one fetus is without a heart; blood circulation is maintained by an accompanying "pump" twin. Such an acardiac condition is usually diagnosed on the basis of further malformations visible by ultrasonography. We describe a monoamniotic twin pregnancy with early growth reduction in...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00011-5
更新日期:1998-08-28 00:00:00
abstract::Modifications of brain-stem acoustic evoked potentials (BAEPs) in the first 5 days of life of normal full-term infants are reported. BAEPs were recorded using rarefaction clicks at 70, 60, 40, 20 dB HL. Multiple linear regression analysis was performed to evaluate chronological and gestational age differences for all ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90034-z
更新日期:1991-11-01 00:00:00
abstract::The modern successes of reproductive medicine are based on the achievements in the fields of artificial fertilization and cryobiology over the last 50years. Cryopreservation of oocytes makes it possible to preserve their reproductive potential after surgical interventions, treatment of cancer, for delayed pregnancy an...
journal_title:Early human development
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.earlhumdev.2018.08.016
更新日期:2018-11-01 00:00:00
abstract::Interfacility transport is a necessary part of hospital care. Neonates often need to access specialist input at different sites necessitating a reliable transfer process. Services have evolved significantly over the last ten years to meet this need. This followed the recognition that ad hoc arrangements were unreliabl...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.09.004
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Hypoxic-ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. The use of levetiracetam (LEV), as a potential neuroprotective in brain ischemia, receives an increasingly high attention, and it could have a crucial role in the regulation of epileptogenesis and neuroprotection. Pot...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.12.002
更新日期:2013-05-01 00:00:00
abstract::Cord blood thyroxine (T4) concentrations were measured in 4,068 infants from 28 wk gestation to term. Each chart was reviewed for the following factors: delivery by cesarean section, prolonged rupture of membranes, neonatal asphyxia, meconium-stained amniotic fluid, maternal diabetes mellitus and twinning. Each neonat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(78)90031-2
更新日期:1978-09-01 00:00:00
abstract::Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct inte...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2010.01.008
更新日期:2010-07-01 00:00:00
abstract::The transitional circulation of the preterm infant differs significantly from the term infant. The preterm infant is uniquely at risk of hypotension and low systemic blood flow states due to failure or delay in the normal transitional circulation processes. The maintenance of normal tissue oxygenation requires mainten...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2005.03.006
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:A short course of moderately early dexamethasone therapy with a starting dose of 0.5 mg/kg/day improves lung compliance and shortens the duration of ventilatory support in preterm infants with respiratory distress syndrome (RDS). We conducted a double-blind, randomized study to evaluate whether a moderately e...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-3782(03)00082-3
更新日期:2003-10-01 00:00:00