Abstract：
BACKGROUND:The kidney is one organ which presents distinct morphology depending on GA; the classic references for kidney measurements were established several years ago and it is not certain if they are still accurate. AIM:To evaluate the renal maturity using a computer-assisted morphometry in autopsied fetuses within 20 to 40 weeks of GA. STUDY DESIGN:Microscopic hematoxylin and eosin stained renal sections from 67 stillborns were utilized for the morphometric analyses. RESULTS:It was possible to promote an adjustment in the formula used to calculate the number of mature glomeruli layers to the GA (GLN = 0.212GA + 0.0169) in autopsy material and it was different from the literature (Sr = 0.709; p < 0.001). Regarding the nephrogenic zone, it decreases with the GA as confirmed by the regression equation NZ = 490.7-(11.9 x GA) (p < 0.001; Sr = -0.685). CONCLUSION:In conclusion, our data contribute to the evaluation of renal maturity and GA in autopsied fetuses, showing particular importance in autolyzed fetuses, in which the parameters used in the present study can still be applied. The correction of the formula for counting mature glomeruli layers for each GA and the addition of new morphometric parameters for the evaluation of renal maturity increase the precision for the analysis of spontaneous abortion and autopsy material, improving the correlation with pathological processes in clinical findings and in the other organs.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
dos Santos AM,Fonseca Ferraz ML,Pinto Rodriguez ML,Dos Reis MA,Miranda Corrêa RR,de Paula Antunes Teixeira V,da Cunha Castro ECdoi
10.1016/j.earlhumdev.2006.01.013subject
Has Abstractpub_date
2006-11-01 00:00:00pages
709-13issue
11eissn
0378-3782issn
1872-6232pii
S0378-3782(06)00070-3journal_volume
82pub_type
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journal_title：Early human development
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journal_title：Early human development
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
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