Progression of outflow tract obstruction in the fetus.

Abstract:

:Fetal ventricular outflow tract obstruction (OTO) is congenital heart disease with significant potential for progression before birth as a consequence of the unique nature of the fetal circulation. The pattern of evolution depends upon the timing of development, severity of obstruction and the influence of the OTO on the fetal atrioventricular valve and myocardial function. Critical aortic (AS) or pulmonary (PS) valve stenosis, the two most common forms of fetal OTO, may be associated with progressive ventricular and great artery hypoplasia if presenting early in gestation or with normal ventricular and great artery growth if evolving later in gestation. In some affected fetuses, AS or PS may lead to the evolution of fetal heart failure. This article will review our current understanding of the natural history of fetal AS and PS, experience with fetal intervention and future directions of research.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Yamamoto Y,Hornberger LK

doi

10.1016/j.earlhumdev.2012.02.005

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

279-85

issue

5

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(12)00059-X

journal_volume

88

pub_type

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