Is fetal insulin secretion affected by fetal hypoxia?

Abstract:

:Fifty-five pregnant Rhesus isoimmunized women were subjected to fetal blood sampling or fetal blood transfusion on 135 occasions. Glucose and C-peptide concentrations were measured in fetal blood, in addition to the routine investigations for complete blood count, blood gases and lactate concentration, in order to investigate whether fetal insulin secretion was affected by hypoxia from fetal anemia. We found a strong relation between the concentration of C-peptide and gestational age at sampling (r = 0.53, P less than or equal to 0.000001). Multiple regression analysis also demonstrated that glucose (P less than or equal to 0.0051) and lactate (P less than or equal to 0.0003) also affected the concentration of C-peptide. We were unable to find any relation between C-peptide concentrations and blood gas variables. We conclude that fetal insulin secretion, measured as C-peptide concentration in fetal blood, is not affected by hypoxia from anemia as long as hemoglobin concentration remains within the range 2.1-14.8 g/dl).

journal_name

Early Hum Dev

journal_title

Early human development

authors

Stangenberg M,Sasidharan P

doi

10.1016/0378-3782(90)90027-g

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

201-8

issue

3

eissn

0378-3782

issn

1872-6232

pii

0378-3782(90)90027-G

journal_volume

24

pub_type

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