Abstract：
:The brain glycoconjugates, glycosidases and lipids have been studied in a case of human congenital athyroidism never treated with hormonal replacement. Increase of membrane-bound mucopolysaccharides has been found in the grey matter. Total lipids in the white matter, and phospholipids, and total glycolipids and cholesterol in both white and grey matter were reduced. Sialic acid (NeuNAc) and hexosamines in the cytosol grey matter were significantly raised, while they were reduced in the membrane-bound grey fraction. These biochemical findings confirm impairment of the myelination process in human hypothyroidism as is well established in experimental hypothyroidism. The significant changes in the carbohydrate moieties of the brain glycoproteins focus attention on complex alterations of structure and function of the cell plasma membranes.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Annunziata P,Federico A,D'Amore I,Corona RM,Guazzi GCdoi
10.1016/0378-3782(83)90009-9subject
Has Abstractpub_date
1983-10-01 00:00:00pages
269-78issue
3-4eissn
0378-3782issn
1872-6232pii
0378-3782(83)90009-9journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Fetal cells exfoliate in the uterine cavity during early pregnancy and are a potential source of material for NIPD. AIMS:This study was designed to test the hypothesis that fetal cells obtained from the uterine cervix during the first trimester of pregnancy could be utilized for prenatal diagnosis of chromo...
journal_title：Early human development
pub_type： 临床试验,杂志文章
doi：10.1016/j.earlhumdev.2010.04.005
更新日期：2010-05-01 00:00:00
abstract：:Interfacility transport is a necessary part of hospital care. Neonates often need to access specialist input at different sites necessitating a reliable transfer process. Services have evolved significantly over the last ten years to meet this need. This followed the recognition that ad hoc arrangements were unreliabl...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:Management of neonatal hydronephrosis is a clinical challenge. The natural history of hydronephrosis has shown that most resolve spontaneously; however, there are a significant number that do not. Although hydronephrosis does not always mean obstruction, it becomes the clinician's role to determine when obstruction wi...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.11.004
更新日期：2006-01-01 00:00:00
abstract：:Advances in pharmacology and technology have sharply reduced mortality of extremely preterm infants at the expense of an increasing number of survivors with handicaps and disabilities. The EURONIC study among neonatal intensive care units across Europe demonstrates that treatment of infants born at the limits of viabi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.10.004
更新日期：2005-12-01 00:00:00
abstract：:We studied the ontogeny and temporal organization of non-nutritive sucking during active sleep in 6 healthy preterm infants (mean birthweight 1.1 kg (range 0.8-1.3 kg) gestational age 28.6 weeks (range 26-30 w] from 30 to 35 weeks of post-menstrual (PM) age. Recognizable rhythmical sucking bursts were recorded at 28 w...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90100-8
更新日期：1985-07-01 00:00:00
abstract：:Dexamethasone (DEX), a synthetic glucocorticoid, has been widely used to prevent the development of a variety of poor health conditions in premature infants including chronic lung disease, inflammation, circulatory failure, and shock. Although there are some reports of neurologic complications related to DEX exposure,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.10.007
更新日期：2013-05-01 00:00:00
abstract：:The effect of fetal growth restriction on cardiac size is controversial. It has not been established whether cardiac size of small for gestational age (SGA) fetuses is smaller or larger than appropriate for gestational age (AGA) fetuses. Such controversy may stem from heterogeneity in study population in previous repo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(96)01840-3
更新日期：1997-04-25 00:00:00
abstract：BACKGROUND:Parent perception of child vulnerability (PPCV) and parent overprotection (POP) are believed to have serious implications for age appropriate cognitive and psychosocial development in very low birth weight preterm children. AIM:With recent concerns about suboptimal developmental outcomes in late-preterm chi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.07.005
更新日期：2010-09-01 00:00:00
abstract：:The behavior exhibited by human fathers at their first contact with the young was studied on 15 fathers of full-term infants delivered by cesarean section. The naked infant was presented to the father approximately 15 min after delivery, and photographs were taken every second during the first 7 min of contact. An ord...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90017-3
更新日期：1979-03-01 00:00:00
abstract：BACKGROUND:Tyrosine hydroxylase (TH) is a specific marker for catecholaminergic neurones. Some reports have demonstrated a decrease of TH in the Sudden Infant Death Syndrome (SIDS) compared with controls. To further investigate this, the correlation between TH and sleep apnea was investigated here. MATERIALS AND METHO...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.08.007
更新日期：2003-12-01 00:00:00
abstract：AIMS:1. To determine the survival and morbidity of infants at discharge with a birthweight of less than 1500 g in the geographically defined population of East Anglia. 2. To demonstrate a cost-effective method of regional data collection. 3. To determine whether there were any changes in the demand for neonatal care. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.10.019
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Preterm birth is a known risk factor for infant development but it is less clear whether fetal growth restriction (FGR) and early term birth between 37 and 39 weeks gestation are associated with risks for infant development. AIMS:This study investigated risk factors for adverse developmental outcomes at 12 ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.104951
更新日期：2020-03-01 00:00:00
abstract：:Cranial ultrasound is the most available and easily repeatable technique for imaging the neonatal brain. Its quality and diagnostic accuracy depend on various factors; the suitability of the ultrasound machine for neonatal cranial work, the use of optimal settings and probes, appropriate scanning protocols, the use of...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2006.09.018
更新日期：2006-12-01 00:00:00
abstract：:We assessed the relation of perinatal factors to severe hypothyroxinemia of prematurity, defined as thyroxine value more than 2.6 standard deviations below the mean for newborns. The 365 survivors of birth before 32 weeks gestation were enrolled in a population-based study of the correlates of neonatal brain injury. I...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(96)01843-9
更新日期：1997-01-20 00:00:00
abstract：:The objective of this work was to examine the changes in the fatty acid profiles of plasma lipid fractions and red blood cell membrane phospholipids in newborn infants during the first 6-8 h of life. Methyl esters of fatty acids from plasma free fatty acids and phospholipids and from membrane phosphatidylethanolamine,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(87)90041-7
更新日期：1987-03-01 00:00:00
abstract：:The study set out to document child care practices in as many different countries and cultures as possible with the aim of providing baseline child care data and stimulating new hypotheses to explain persisting differences in sudden infant death syndrome (SIDS) rates between countries. The protocol, piloted in four co...
journal_title：Early human development
pub_type： 杂志文章,多中心研究
doi：10.1016/s0378-3782(99)00021-3
更新日期：1999-06-01 00:00:00
abstract：:The aim of the study was to evaluate potential changes of cerebral blood volume (CBV) related to arousals in preterm infants. As arousals are known to change different physiological parameters, it was postulated that this could also hold true for CBV. Polygraphic recordings were performed in 38 preterm infants (18 fem...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.05.019
更新日期：2007-04-01 00:00:00
abstract：:Prior research in newborns has shown that head-up and head-down tilting elicits sustained increases and decreases in heart rate, respectively. Other studies in older infants have suggested that the pattern of heart rate responses to head-up tilting varies with risk for sudden infant death syndrome (SIDS). In this stud...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00026-2
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Maternal pre-pregnancy overweight is known to program offspring for adverse health outcomes later in life. AIMS:To investigate how growth patterns of weight, height and BMI from birth to 7years differ according to maternal pre-pregnancy weight (normal weight, overweight and obesity), with specific attention...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2017.06.002
更新日期：2017-10-01 00:00:00
abstract：:A new protocol for structured observation of motor performance in infants, SOMP-I, was applied to 72 neonatally healthy fullterm infants at 0, 2, 4, 6 and 10 months of age. It contains 13 items, formed as ascending scales, consisting of detailed descriptions of motor performance in different body positions and body pa...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)01598-J
更新日期：1995-01-30 00:00:00
abstract：:Bilirubin-albumin binding was quantitated (peroxidase method) before, during, and after phototherapy in 21 jaundiced infants. Binding was analyzed at two different serum dilutions (1:1.8 and 1:57) to determine whether binding competitors are present during phototherapy. No significant changes in binding were found at ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90099-8
更新日期：1982-04-01 00:00:00
abstract：:Maturation of spontaneous fetal body and breathing movements of 24- to 33-week-old fetuses in 168 pregnancies threatening to deliver prematurely were examined on the basis of newborn outcome (premature compromised, premature healthy, term healthy). Maturation of fetuses in 60 low-risk pregnancies delivering as healthy...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00007-9
更新日期：1999-05-01 00:00:00
abstract：:Fetal ventricular outflow tract obstruction (OTO) is congenital heart disease with significant potential for progression before birth as a consequence of the unique nature of the fetal circulation. The pattern of evolution depends upon the timing of development, severity of obstruction and the influence of the OTO on ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.02.005
更新日期：2012-05-01 00:00:00
abstract：:In a prospective clinical study from an unselected, area-based population, the influence on birthweight for gestational age of different factors was studied, with special respect to 15 risk factors for intrauterine growth retardation (IUGR) recognizable in early pregnancy. In the multiple regression analyses performed...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90110-5
更新日期：1984-09-01 00:00:00
abstract：:Studies in encephalopathic infants have demonstrated a brief phase of normal cerebral energetics following hypoxia-ischaemia prior to development of delayed energy failure. In experimental models, mild hypothermia has shown a consistent neuroprotective action, although its efficacy is critically dependent on the sever...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.014
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Retinopathy of prematurity (ROP) is often associated with visual impairment and multiple developmental disabilities. AIMS:As most of the previous studies include infants with brain lesions, that can determine visual impairment per se, a cohort of low neurological risk preterm infants without ROP and with va...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105134
更新日期：2020-09-01 00:00:00
abstract：:CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosis and treatment of congenita...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2011.08.021
更新日期：2011-11-01 00:00:00
abstract：:Forty-four prenatally depressed women were randomly assigned to peer support or interpersonal psychotherapy groups at 22 weeks gestation. The peer support group participated in a 20-minute group session once per week for 12 weeks, and the interpersonal psychotherapy group met for one hour per week for 12 weeks. Assess...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.earlhumdev.2013.04.006
更新日期：2013-09-01 00:00:00
abstract：:Ninety five placentae from normal term and 'normal' preterm pregnancies have been analysed by morphometry. The growth of the whole placenta, of the microscopic placental constituents and of the villous surface area has been measured in placentae from uncomplicated pregnancies from 10 weeks of gestation to term to prov...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90074-4
更新日期：1984-06-01 00:00:00
abstract：:Hepatic glucose production by glycogenolysis and gluconeogenesis is essential to maintain blood glucose levels, and the glucose-6-phosphatase system catalyses the terminal step of both pathways. Developmental delays in the postnatal up-regulation of hepatic glucose-6-phosphatase enzyme activity are common in preterm i...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.005
更新日期：2005-01-01 00:00:00
