Abstract：
:Dexamethasone (DEX), a synthetic glucocorticoid, has been widely used to prevent the development of a variety of poor health conditions in premature infants including chronic lung disease, inflammation, circulatory failure, and shock. Although there are some reports of neurologic complications related to DEX exposure, its full effects on the premature brain have not been examined in detail. To investigate the effects of DEX on neural development, we first administered low doses (0.2 mg/kg bodyweight or less) of the glucocorticoid to neonatal rats on a daily basis during the first postnatal week and examined subsequent behavioral alterations at the juvenile stage. DEX-treated rats exhibited not only a significant reduction in both somatic and brain weights but also learning disabilities as revealed in the shuttle avoidance test. The hippocampi of DEX-treated rats displayed a high apoptotic and a low mitotic cell density compared to control rats on day 7 after birth. In a subsequent experiment, neural stem/progenitor cells were cultured in the presence of DEX for 6 days. The glucocorticoid inhibited cell growth without an increase in cell death. These results suggest that administration of DEX to premature infants induces neurological dysfunction via inhibition of the proliferation of neural stem/progenitor cells.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Ichinohashi Y,Sato Y,Saito A,Ito M,Watanabe K,Hayakawa M,Nakanishi K,Wakatsuki A,Oohira Adoi
10.1016/j.earlhumdev.2012.10.007subject
Has Abstractpub_date
2013-05-01 00:00:00pages
283-8issue
5eissn
0378-3782issn
1872-6232pii
S0378-3782(12)00250-2journal_volume
89pub_type
杂志文章abstract：:Son preference remains common in countries from East Asia through South Asia to the Middle East and North Africa. Where sex selective technology and abortion are readily available, such as in China, South Korea and India, this has led to a marked excess in male births. Worst excesses are seen in parts of rural China w...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.08.016
更新日期：2011-11-01 00:00:00
abstract：:In the last two decades the survival of extreme preterm infants and sick newborn infants has improved significantly due to the advances in perinatal medicine. Despite this advance, for some babies, withholding or withdrawal of life sustaining treatment may be the best option in the interest of the baby. An overview of...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.01.002
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abstract：:Developmental changes in muscle coordination patterns of normal and abnormal general movements (GMs) are described. GMs were studied simultaneously with video-recording and polymyography (polyEMG). GMs of normal full-term infants gradually lose their neonatally slow and 'writhing' character, to be turned into the eleg...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(93)90038-v
更新日期：1993-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Early human development
pub_type： 杂志文章,评审
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00049-2
更新日期：1998-02-27 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105211
更新日期：2020-10-03 00:00:00
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pub_type： 杂志文章
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更新日期：1988-05-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.09.011
更新日期：2013-11-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2002-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,多中心研究
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更新日期：1999-06-01 00:00:00
abstract：:Twenty-eight very low birth weight (VLBW) and 32 full term infants were prospectively assessed at one year of age for hearing, language development and neurological status. The prevalence of conductive hearing deficits was the same in both groups. Language scores in VLBW infants were significantly lower than in fullte...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90007-6
更新日期：1990-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.06.012
更新日期：2010-08-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.09.011
更新日期：2014-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.01.030
更新日期：2011-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90197-3
更新日期：1993-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.06.006
更新日期：2011-12-01 00:00:00
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journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90152-5
更新日期：1985-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90114-3
更新日期：1986-10-01 00:00:00
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pub_type： 杂志文章,实务指引
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更新日期：2020-05-01 00:00:00
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pub_type： 历史文章,杂志文章,评审
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更新日期：2018-11-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(03)00009-4
更新日期：2003-05-01 00:00:00
