Abstract：
:Human and animal studies demonstrate that uteroplacental insufficiency and subsequent intrauterine growth retardation (IUGR) decrease intestinal growth and lead to both an increased incidence of feeding intolerance and necrotizing enterocolitis. Our objective was to determine the effects of uteroplacental insufficiency upon small intestine growth, histology, gene expression of the apoptosis related proteins Bcl-2, Bax and p53, and caspase-3 activity. For this purpose, we induced uteroplacental insufficiency through bilateral uterine artery ligation on day 19 of gestation in fully anesthetized pregnant Sprague-Dawley rats and harvested pups at term 2 days latter. Pups from sham surgeries served as controls. Uteroplacental insufficiency reduced cell count per crypt and decreased small intestinal weight. In association with these changes, IUGR intestinal Bcl-2 mRNA levels were decreased significantly, and Bax and p53 mRNA were significantly increased in distal ileum. Immunohistochemistry for Bcl-2, Bax, and p53 revealed similar findings. In association with the decreased Bcl-2 and the increased Bax gene expression, increased caspase-3 activity characterized the IUGR distal ileum. We conclude that uteroplacental insufficiency affects intestinal growth and morphology in association with altered gene expression of apoptosis related proteins. We speculate that the morphological change and associated altered apoptotic homeostasis contribute to the increased morbidity of infants affected by uteroplacental insufficiency.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Baserga M,Bertolotto C,Maclennan NK,Hsu JL,Pham T,Laksana GS,Lane RHdoi
10.1016/j.earlhumdev.2004.04.015keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
93-105issue
2eissn
0378-3782issn
1872-6232pii
S0378-3782(04)00075-1journal_volume
79pub_type
杂志文章abstract：OBJECTIVE:To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS:Eighty-one preterm infants b...
journal_title：Early human development
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章,评审
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abstract：:We have shown for the first time that the microsomal glucose-6-phosphatase enzyme protein is present in human embryonic and fetal red blood cells and the ontogeny of its expression has been determined. In the earliest embryos, red cells are predominantly of the primitive megaloblastic type. Circulating red cells in th...
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doi：10.1016/0378-3782(95)01626-e
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journal_title：Early human development
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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更新日期：1999-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.005
更新日期：2005-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(83)90007-5
更新日期：1983-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.07.004
更新日期：2005-03-01 00:00:00
abstract：:Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-1 (IGFBP-1) were measured in amniotic fluid, extraembryonic coelomic fluid and maternal serum from 23 women with apparently normal first trimester pregnancies prior to termination. The levels of IGF-1 and IGFBP-1 were significantly hig...
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pub_type： 杂志文章
doi：10.1016/0378-3782(92)90105-p
更新日期：1992-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90124-4
更新日期：1982-07-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)00119-9
更新日期：1998-07-10 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.01.004
更新日期：2004-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2013-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90027-g
更新日期：1990-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.02.002
更新日期：2013-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.07.006
更新日期：2005-11-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2014.08.022
更新日期：2014-11-01 00:00:00
abstract：:This study examined the oral sensitivity and feeding skills of low-risk pre-term infants at 11-17 months corrected age. Twenty pre-term infants (PT) born between 32 and 37 weeks at birth without any medical comorbidities were assessed. All of this PT group received supplemental nasogastric (NG) tube feeds during their...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.10.001
更新日期：2004-01-01 00:00:00
