Abstract：
BACKGROUND:Infants whose mothers had low serum pregnancy-associated plasma protein-A (PAPP-A) in the first trimester were observed to have intrauterine growth retardation. AIM:Suggesting that PAPP-A plays an important role in the availability and activity of insulin-like growth factors (IGFs), which affect growth, we aimed to investigate cord blood PAPP-A levels of infants with different birth lengths and weights. STUDY DESIGN AND OUTCOME MEASURES: The study included 97 full-term, live-birth neonates. After birth, their lengths and weights were measured. Cord blood PAPP-A levels were measured with an ultra sensitive enzyme-linked immunosorbent assay (ELISA). RESULTS:There was a significant negative correlation between cord blood PAPP-A levels and birth weight (r=-0.23; P=0.023) and length (r=-0.24; P=0.016). Using the classification made according to their length, it was found that newborns with short lengths had significantly higher mean PAPP-A levels than neonates with normal and long lengths (P=0.022; P=0.002, respectively), whereas the difference between infants with normal lengths and infants with long lengths was not found to be statistically significant (P>0.05). On the other hand, there was a difference between the mean PAPP-A levels of the neonate groups classified according to weight; however, these differences were not statistically significant (P>0.05). CONCLUSION:We concluded that increased cord blood PAPP-A levels were associated with birth length and weight decreases; however, PAPP-A levels affected birth length more than birth weight.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Senses DA,Coskun A,Kiseli M,Berberoglu M,Kandemir O,Yalvac S,Duran Sdoi
10.1016/j.earlhumdev.2006.10.005subject
Has Abstractpub_date
2007-07-01 00:00:00pages
479-82issue
7eissn
0378-3782issn
1872-6232pii
S0378-3782(06)00299-4journal_volume
83pub_type
杂志文章abstract：BACKGROUND:There is concern that exposure of preterm infants to noxious insults over a prolonged period may have long term effects on their developing nervous system. AIMS:To investigate medium and long term effects of heel pricks in infants over the first year of life. STUDY DESIGN:Study 1-a longitudinal study, 2 da...
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journal_title：Early human development
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更新日期：1989-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1998-07-10 00:00:00
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journal_title：Early human development
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更新日期：1996-12-30 00:00:00
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journal_title：Early human development
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更新日期：2006-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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journal_title：Early human development
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更新日期：2015-07-01 00:00:00
