Abstract:
BACKGROUND:Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis. AIM:To study the implication of sVEGFR-1-a VEGF antagonist-in IUGR. STUDY DESIGN:Prospective study. METHODS:Twenty-five IUGR and 15 appropriate for gestational age (AGA) full-term fetuses and neonates with their mothers were included in the study. OUTCOME MEASURES:sVEGFR-1 levels were determined by enzyme immunoassay in the serum of: mothers (MS), umbilical cords (UC)-representing fetal state - and neonates on day 1 (N1) and 4 (N4) of life. RESULTS:MS, UC, N1 and N4 sVEGFR-1 levels in IUGR were significantly higher compared to respective AGA cases (p = 0.005, p = 0.026, p = 0.005 and p = 0.017, respectively). In IUGR and AGA groups, maternal sVEGFR-1 levels were significantly higher than fetal and neonatal levels (p in all cases < 0.001). The latter presented in both IUGR and AGA groups a significant decrease from UC to N4 (p in all cases < 0.01). MS, N1 and N4 sVEGFR-1 levels negatively correlated with the infants' customized centiles [(r = -0.489, p = 0.001), (r = -0.440, p = 0.004), (r = -0.431, p = 0.006), respectively]. CONCLUSIONS:Higher sVEGFR-1 levels in the IUGR as compared to the AGA group possibly reflect the predominance of antiangiogenic mechanisms present in IUGR. The decrease of sVEGFR-1 levels from UC to N4 may represent ex utero initiation of growth and development and therefore, prevalence of angiogenic mechanisms.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Boutsikou T,Malamitsi-Puchner A,Economou E,Boutsikou M,Puchner KP,Hassiakos Ddoi
10.1016/j.earlhumdev.2005.09.010keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
235-9issue
4eissn
0378-3782issn
1872-6232pii
S0378-3782(05)00204-5journal_volume
82pub_type
杂志文章abstract::Altogether 2159 pregnancies among black and white Americans in the Collaborative Perinatal Study and dental casts from the children at the age of 5-12 years were studied to find out the effect of maternal smoking on deciduous tooth crown growth. Minor crown size reduction (2-3%) in some dimensions was found in childre...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90086-v
更新日期:1992-08-01 00:00:00
abstract::Pulse oximetry screening is a highly specific, moderately sensitive test for detecting critical congenital heart defects (CCHDs) that meets the criteria for universal screening. The possibility of using pulse oximetry as a screening test was first investigated over 10 years ago and since then data from more than 370,0...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(14)50006-0
更新日期:2014-09-01 00:00:00
abstract::The prone sleeping position has been identified in world-wide epidemiological studies as a major risk factor for sudden infant death syndrome (SIDS). Public awareness campaigns throughout the western world have led to an over 50% reduction in postneonatal mortality and frequency of SIDS. This reduction in mortality ha...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/s0378-3782(02)00025-7
更新日期:2002-10-01 00:00:00
abstract::Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(83)90068-3
更新日期:1983-07-01 00:00:00
abstract::A significant improvement has been achieved in perinatal mortality figures during the last decade in Japan with a neonatal mortality rate of 2.6 and a stillbirth rate of 4.1 for 1989. With its unique obstetric and neonatal services, there are advantages and also disadvantages in respect of clinical and basic research....
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90185-j
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Gastroschisis and omphalocele are the most common anterior abdominal wall defects affecting infants. There are few large cohort studies describing the frequency of associated anomalies in infants with these 2 conditions. We describe associated anomalies and outcomes in infants with these defects using a larg...
journal_title:Early human development
pub_type: 杂志文章,多中心研究
doi:10.1016/j.earlhumdev.2014.05.006
更新日期:2014-08-01 00:00:00
abstract::Maternal milk four days post partum contained immunoreactive calcitonin in concentrations which were 22-89 times higher than those noted in concomitantly sampled maternal sera. Neurotensin-like immunoreactivity was barely detectable in milk. It is suggested that calcitonin may be a prerequisite for the concentration o...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90060-3
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Human milk contains a range of host defence proteins that appear to contribute to health and wellbeing, but their variability in abundance among individuals has not been very well characterised. Milk from mothers of premature infants has altered composition, but the effect of gestation length on the host-def...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.11.006
更新日期:2015-01-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1989-12-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1994-04-30 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(93)90038-v
更新日期:1993-09-01 00:00:00
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journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-12-01 00:00:00
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journal_title:Early human development
pub_type: 临床试验,杂志文章
doi:10.1016/j.earlhumdev.2010.04.005
更新日期:2010-05-01 00:00:00
abstract::Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is ...
journal_title:Early human development
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
abstract::Surfactant is now available for general clinical use in infants with RDS. While surfactant is effective, it does not prevent lung disease in many preterm infants because of other aspects of lung immaturity. In experimental models, corticosteroids alter the fetal lung by improving compliances, increasing lung volumes, ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(92)90058-o
更新日期:1992-06-01 00:00:00
abstract::Blood flow velocity was measured in both main stem uterine arteries by means of a transvaginally inserted Duplex scanner (240 degrees sector, pulsed Doppler) and visual vessel recognition to investigate normal and abnormal uterine perfusion. Its relationship to fetal circulation and fetal outcome was studied. Fetal ve...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90115-j
更新日期:1991-06-01 00:00:00
abstract::We have shown for the first time that the microsomal glucose-6-phosphatase enzyme protein is present in human embryonic and fetal red blood cells and the ontogeny of its expression has been determined. In the earliest embryos, red cells are predominantly of the primitive megaloblastic type. Circulating red cells in th...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01626-e
更新日期:1995-06-21 00:00:00
abstract::Given the widely acknowledged inverse relationship between birth weight and blood pressure, a raised blood pressure in the offspring of smoking mothers as compared to those whose mothers did not smoke, would be anticipated by virtue of the reduction in birth weight associated with smoking during pregnancy. The objecti...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00064-x
更新日期:2000-02-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,多中心研究
doi:10.1016/j.earlhumdev.2011.07.001
更新日期:2012-01-01 00:00:00
abstract::A new protocol for Structured Observation of Motor Performance in Infants, SOMP-I, designed to describe both progress and quality of motor performance, was evaluated concerning its ability to describe and to discriminate between the motor performance observed in different groups of infants. Sixty-eight infants born at...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01678-3
更新日期:1995-11-24 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.03.013
更新日期:2013-07-01 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is one of the most important sequelae of premature birth and the most common form of chronic lung disease of infancy. From a clinical standpoint BPD subjects are characterized by recurrent respiratory symptoms, which are very frequent during the first years of life and, although becomi...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.07.015
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Fluconazole prophylaxis has demonstrated efficacy in single and multicenter randomized controlled trials without side effects or emergence of resistance. Additional evidence based on incidence of invasive Candida infections, multicenter data, resistance, and safety is desired. METHODS:We conducted a case-co...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0378-3782(14)70026-X
更新日期:2014-03-01 00:00:00
abstract::Maturation of spontaneous fetal body and breathing movements of 24- to 33-week-old fetuses in 168 pregnancies threatening to deliver prematurely were examined on the basis of newborn outcome (premature compromised, premature healthy, term healthy). Maturation of fetuses in 60 low-risk pregnancies delivering as healthy...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00007-9
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:Many preterm children show difficulties in attention at (pre)school age. The development of attention capacities of preterm and term toddlers was compared using a longitudinal and multi-method approach at 12, 18 and 24months. METHOD:Attention was measured for 123 preterm (32-36weeks gestation) and 101 term b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.08.015
更新日期:2015-12-01 00:00:00
abstract::Pancreatic protease deficiency may be an aetiological factor in enteritis necroticans, a disease sharing some features of necrotising enterocolitis (NEC). Using faecal chymotrypsin measurement we have prospectively studied pancreatic exocrine function in infants at risk of NEC. No significant difference was found comp...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(93)90100-9
更新日期:1993-12-15 00:00:00
abstract:AIMS:To study longitudinal growth pattern of head circumference of full-term symmetric and asymmetric small for gestational age (SGA) infants of the two sexes during first year of life. STUDY DESIGN:Mixed-longitudinal growth research design. SUBJECTS:Head circumference amongst full-term 100 symmetric, 100 asymmetric ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.11.007
更新日期:2012-07-01 00:00:00
abstract:AIM:To compare the order and age of emergence of rolling prone to supine and supine to prone before the introduction of back to sleep guidelines and 20 years after their introduction. METHODS:The original normative data for the Alberta Infant Motor Scale (AIMS) were collected just prior to the introduction of back to ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.10.009
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To determine whether proportionate or disproportionate foetal smallness at 17 to 19 weeks of gestation in low-risk pregnancies was associated with size, body constitution, and adverse outcome at birth. METHODS:We included ultrasound measurements at 17-19 weeks of gestation in 7285 uncomplicated pregnancies w...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.01.010
更新日期:2006-10-01 00:00:00
abstract::The presence of dilated bowel loops antenatally suggests fetal bowel obstruction. Neonatal intestinal obstruction can have different variations in presentation depending on the level and extent of obstruction. Some of these conditions can be diagnosed antenatally. Antenatal detection of surgically correctable anomalie...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2006.02.005
更新日期:2006-05-01 00:00:00