Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates.

Abstract:

BACKGROUND:Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis. AIM:To study the implication of sVEGFR-1-a VEGF antagonist-in IUGR. STUDY DESIGN:Prospective study. METHODS:Twenty-five IUGR and 15 appropriate for gestational age (AGA) full-term fetuses and neonates with their mothers were included in the study. OUTCOME MEASURES:sVEGFR-1 levels were determined by enzyme immunoassay in the serum of: mothers (MS), umbilical cords (UC)-representing fetal state - and neonates on day 1 (N1) and 4 (N4) of life. RESULTS:MS, UC, N1 and N4 sVEGFR-1 levels in IUGR were significantly higher compared to respective AGA cases (p = 0.005, p = 0.026, p = 0.005 and p = 0.017, respectively). In IUGR and AGA groups, maternal sVEGFR-1 levels were significantly higher than fetal and neonatal levels (p in all cases < 0.001). The latter presented in both IUGR and AGA groups a significant decrease from UC to N4 (p in all cases < 0.01). MS, N1 and N4 sVEGFR-1 levels negatively correlated with the infants' customized centiles [(r = -0.489, p = 0.001), (r = -0.440, p = 0.004), (r = -0.431, p = 0.006), respectively]. CONCLUSIONS:Higher sVEGFR-1 levels in the IUGR as compared to the AGA group possibly reflect the predominance of antiangiogenic mechanisms present in IUGR. The decrease of sVEGFR-1 levels from UC to N4 may represent ex utero initiation of growth and development and therefore, prevalence of angiogenic mechanisms.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Boutsikou T,Malamitsi-Puchner A,Economou E,Boutsikou M,Puchner KP,Hassiakos D

doi

10.1016/j.earlhumdev.2005.09.010

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

235-9

issue

4

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(05)00204-5

journal_volume

82

pub_type

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