Abstract：
:Bronchopulmonary dysplasia (BPD) is one of the most important sequelae of premature birth and the most common form of chronic lung disease of infancy. From a clinical standpoint BPD subjects are characterized by recurrent respiratory symptoms, which are very frequent during the first years of life and, although becoming less severe as children grow up, they remain more common than in term-born controls throughout childhood, adolescence and into adulthood. From a functional point of view BPD subjects show a significant airflow limitation that persists during adolescence and adulthood and they may experience an earlier and steeper decline in lung function during adulthood. Interestingly, patients born prematurely but not developing BPD usually fare better, but they too have airflow limitations during childhood and later on, suggesting that also prematurity per se has life-long detrimental effects on pulmonary function. For the time being, little is known about the presence and nature of pathological mechanisms underlying the clinical and functional picture presented by BPD survivors. Nonetheless, recent data suggest the presence of persistent neutrophilic airway inflammation and oxidative stress and it has been suggested that BPD may be sustained in the long term by inflammatory pathogenic mechanisms similar to those underlying COPD. This hypothesis is intriguing but more pathological data are needed. A better understanding of these pathogenetic mechanisms, in fact, may be able to orient the development of novel targeted therapies or prevention strategies to improve the overall respiratory health of BPD patients.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Carraro S,Filippone M,Da Dalt L,Ferraro V,Maretti M,Bressan S,El Mazloum D,Baraldi Edoi
10.1016/j.earlhumdev.2013.07.015subject
Has Abstractpub_date
2013-10-01 00:00:00pages
S3-5eissn
0378-3782issn
1872-6232pii
S0378-3782(13)00162-Xjournal_volume
89 Suppl 3pub_type
杂志文章,评审abstract：BACKGROUND:Fetal cells exfoliate in the uterine cavity during early pregnancy and are a potential source of material for NIPD. AIMS:This study was designed to test the hypothesis that fetal cells obtained from the uterine cervix during the first trimester of pregnancy could be utilized for prenatal diagnosis of chromo...
journal_title：Early human development
pub_type： 临床试验,杂志文章
doi：10.1016/j.earlhumdev.2010.04.005
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:COVID-19 is pandemic. International travel bans in March 2020 dampened viral spread and resulted in an overnight global economic crisis. As countries ease travel and social distancing restrictions, viral resurgences are expected. This study was carried out in order to delineate the development of a second ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105211
更新日期：2020-10-03 00:00:00
abstract：:Unexpected death in infancy may be a consequence of recognisable pathophysiological processes, or may remain unexplained after thorough investigation. We review the appropriate investigations that should be performed after unexpected infant deaths, and the recent changes to UK law that will make such investigations ma...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2006.09.012
更新日期：2006-12-01 00:00:00
abstract：:Cerebral blood flow velocity (CBFV) was measured using Doppler ultrasound on the first day of life in a consecutively admitted cohort of 52 very low birthweight infants. Recordings were made for a period of 1 min. The coefficient of variation for the area under the curve of 20 successive cardiac cycles was calculated,...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(96)01769-0
更新日期：1997-01-03 00:00:00
abstract：:In the infant, sucking behaviour is one of the first coordinated muscular activities. It is under the control of the brainstem. In utero sucking is observed from 13 weeks' gestation. The healthy full-term newborn infant has a very stable rhythm of alternating bursts of sucking with pauses in between. The non-nutritive...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00091-8
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Kangaroo care, i.e., skin-to-skin cohabitation (SSC) between an infant and caregiver, is often used in neonatal intensive care units to promote bonding, breastfeeding and infant growth. The direct salutary effects of SSC on cardio-respiratory control in preterm infants remain equivocal; some reports suggest ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.08.015
更新日期：2014-12-01 00:00:00
abstract：:The worst of institutional care was brought to public attention in Romania during the 1990s when pictures of severely deprived and malnourished children were shown around the world. However, many European countries have high rates of young children in institutions, where the physical care of the child predominates, wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.09.018
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Patent ductus arteriosus (PDA) is common in extremely premature infants and associated with increased morbidity and mortality. Medical management of PDA uses either indomethacin or ibuprofen. Despite numerous studies, uncertainty exists as to which drug is safer or more effective; we sought to fill this know...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:Maturation of spontaneous fetal body and breathing movements of 24- to 33-week-old fetuses in 168 pregnancies threatening to deliver prematurely were examined on the basis of newborn outcome (premature compromised, premature healthy, term healthy). Maturation of fetuses in 60 low-risk pregnancies delivering as healthy...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00007-9
更新日期：1999-05-01 00:00:00
abstract：:Here presented are the different human fetal larynx functions. Analysis and observation of the organ show at least three behavioural patterns: swallowing, respiratory and phonetic. The respiratory function coincides with a blood aspiration through the venosus duct (phenomenon measured by pulsed Doppler) which increase...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01721-6
更新日期：1996-07-05 00:00:00
abstract：OBJECTIVE:To identify obstetric risk factors and to elucidate the effect of prolonged rupture of the membranes on the development of cystic periventricular leukomalacia (PVL) in preterm infants. METHODS:A retrospective case-control study of 95 preterm infants with the diagnosis of PVL and 245 healthy controls matched ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.07.007
更新日期：2009-03-01 00:00:00
abstract：:Neonatal hyperglycaemia is a frequent complication in VLBW infants during the first week of life. The more common causes include high glucose intake, stress situations such as sepsis, NEC, and surgical treatments, as well as the administration of vasoactive drugs and methylxanthines. The appropriate definition is uncl...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2011.01.005
更新日期：2011-03-01 00:00:00
abstract：:COVID-19 remains pandemic. Social distancing and travel restrictions have avoided countless deaths and infections but disrupted livelihoods and economies. The global loss of gross (world) product is unprecedented as COVID-19 has inflicted both a supply-side and a demand-side shock. While public health measures have mi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105209
更新日期：2020-10-01 00:00:00
abstract：:Ultrastructural and immunohistochemical studies were made of the testicular interstitial tissue from eight human fetuses of 15 to 27 weeks gestation. Three cell types developed in mesenchymal cells: Leydig cells and peritubular cells, as already reported, and cells of the mononuclear phagocyte system (MPS), which are ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90070-4
更新日期：1989-09-01 00:00:00
abstract：:Pulse oximetry screening for critical congenital heart defects (CCHDs) is a highly specific, moderately sensitive test which is cost effective, acceptable to both clinical staff and parents and meets the criteria for universal screening. Pulse oximetry screening is gaining considerable worldwide support and last year ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.09.013
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To compare measurements of the upper arm cross-sectional areas (total arm area, arm muscle area, and arm fat area of healthy neonates) as calculated using anthropometry with the values obtained by ultrasonography. MATERIALS AND METHODS:This study was performed on 60 consecutively born healthy neonates: gesta...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00085-1
更新日期：1999-03-01 00:00:00
abstract：:The validity of the Wigglesworth experimental model to produce newborn rats that are small for gestational age by ligation of one of both uterine vessels was confirmed. Newborn rats from the opposite horns are used as controls in the classical model. It is concluded from this study that newborns from sham-operated dam...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90038-0
更新日期：1979-09-01 00:00:00
abstract：:The potential use of a piglet as a model for investigation of brain blood flow was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn piglets. Blood pressure was altered by phlebotomy. When the mean arterial blood pressure was greater than 50 mm Hg, no significant change in bra...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90063-9
更新日期：1982-01-01 00:00:00
abstract：:Prior research in newborns has shown that head-up and head-down tilting elicits sustained increases and decreases in heart rate, respectively. Other studies in older infants have suggested that the pattern of heart rate responses to head-up tilting varies with risk for sudden infant death syndrome (SIDS). In this stud...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00026-2
更新日期：1999-07-01 00:00:00
abstract：:We have shown for the first time that the microsomal glucose-6-phosphatase enzyme protein is present in human embryonic and fetal red blood cells and the ontogeny of its expression has been determined. In the earliest embryos, red cells are predominantly of the primitive megaloblastic type. Circulating red cells in th...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01626-e
更新日期：1995-06-21 00:00:00
abstract：:The idea of an artificial neural network is introduced in a historical context, and the essential aspect of it, viz., the modifiable synapse, is compared to the aspect of plasticity in the natural nervous system. Based on such an artificial neural network, a model is presented for the way in which (the path along whic...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(93)90045-v
更新日期：1993-09-01 00:00:00
abstract：:The reactions of heart rate (HR), systolic (sBP) and diastolic (dBP) blood pressure were studied in response to passive head-up tilting (successively to +45 degrees and +90 degrees) in a group of 83 full-term, 1- to 7-day-old newborns who were quiet and awake. A significant mean increase of HR was noted for the whole ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01706-2
更新日期：1996-03-22 00:00:00
abstract：:Urinary epidermal growth factor (EGF) excretion was studied serially in 36 newborn infants, from 26 to 40 weeks gestation, from birth to three months of age. All infants excreted EGF from birth. Excretion was significantly higher in term infants than in preterm infants at birth; in term infants excretion rose steadily...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90190-8
更新日期：1986-12-01 00:00:00
abstract：AIMS:The aim of the current study was to developed and test the reliability of a technique for measuring temporal parameters of sucking in breastfeeding infants. METHODS:The technique was developed using a cohort of 11 term and 12 preterm infants, and subsequently evaluated using a cohort of 43 preterm infants. Measur...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.04.008
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Obstetrical and neonatal complications and/or an adverse parenting environment are risk factors for language impairment, but little is known about their effects on early word production (late talking). AIMS:To determine obstetrical and neonatal risk factors in children with delayed word production; to asses...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2006.05.009
更新日期：2007-02-01 00:00:00
abstract：:This paper describes the use of automated microscopy to detect fetal erythroblasts in maternal blood. The technology is based on the following approach: (1) the use of centrifugal cytology for the preparation of monolayers; (2) simultaneous staining of fetal hemoglobin (immunoalkaline phosphatase) and chromosome seque...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(96)01829-4
更新日期：1996-12-30 00:00:00
abstract：:Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.10.008
更新日期：2012-06-01 00:00:00
abstract：:Oesophageal pressure and ventilation were recorded during sleep in healthy full-term neonates with sleep state defined by one of two methods; in 35 infants by combined behavioural and electroencephalographic criteria, and in a further 13 infants by behavioural criteria alone. Spontaneous oesophageal contractions occur...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(88)90054-0
更新日期：1988-12-01 00:00:00
abstract：BACKGROUND:Preterm infants have a high risk of cranial deformity resulting from external pressures. Such deformity is associated with delayed neurodevelopment. AIMS:We aimed to clarify the effects of continuous use of positioning pillows on cranial deformity and neurodevelopment in preterm infants. METHODS:This prosp...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105137
更新日期：2020-09-01 00:00:00
abstract：:Standards for Research (StaR) in Child Health, founded in 2009, addresses the current scarcity of and deficiencies in pediatric clinical trials. StaR Child Health brings together leading international experts devoted to developing practical, evidence-based standards to enrich the reliability and relevance of pediatric...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.09.011
更新日期：2013-11-01 00:00:00
