Abstract:
:This paper describes the use of automated microscopy to detect fetal erythroblasts in maternal blood. The technology is based on the following approach: (1) the use of centrifugal cytology for the preparation of monolayers; (2) simultaneous staining of fetal hemoglobin (immunoalkaline phosphatase) and chromosome sequences (FISH); (3) multi-mode microscopy to detect rare events; (4) visual evaluation of image memories containing detected objects. Model systems show that fetal cells in frequencies as low as 1 in a million cells can be detected easily (manually or by automated microscopy). Algorithms for automated cell selection were developed for a test set of 6 patients. Optimization of hardware and software routines will make analysis of several million cells in approximately 1 h feasible.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Tanke HJ,Oosterwijk JC,Mesker WE,Ouwerkerk van-Velzen MC,Knepflé CF,Wiesmeyer CC,van Ommen GJ,Kanhai HH,Vrolijk Jdoi
10.1016/s0378-3782(96)01829-4subject
Has Abstractpub_date
1996-12-30 00:00:00pages
S89-93eissn
0378-3782issn
1872-6232pii
S0378378296018294journal_volume
47 Supplpub_type
杂志文章abstract::The worst of institutional care was brought to public attention in Romania during the 1990s when pictures of severely deprived and malnourished children were shown around the world. However, many European countries have high rates of young children in institutions, where the physical care of the child predominates, wi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.09.018
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To compare measurements of the upper arm cross-sectional areas (total arm area, arm muscle area, and arm fat area of healthy neonates) as calculated using anthropometry with the values obtained by ultrasonography. MATERIALS AND METHODS:This study was performed on 60 consecutively born healthy neonates: gesta...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00085-1
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of single and repeated courses of antenatal corticosteroids on brain growth in very preterm babies. DESIGN:Retrospective study of 110 very preterm babies delivered at a single University Teaching Hospital between 1992 and 1999 who had a full necropsy including detailed examination...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(01)00144-x
更新日期:2001-07-01 00:00:00
abstract::Mother's own milk is widely recognized as the optimal feeding for term infants, but also provides health benefits that are of vital importance for sick and preterm infants in neonatal intensive care units (NICUs), even though the growth and neurodevelopmental needs of very premature infants are best met by appropriate...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.07.008
更新日期:2013-10-01 00:00:00
abstract::Neonatal sepsis is frequently accompanied by significant and sometimes life-threatening coagulopathy. More complete understanding is needed of the molecular and cellular mechanisms underlying the interaction of the inflammatory and hemostatic systems. Such information may help focus future studies toward novel ways to...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(14)70008-8
更新日期:2014-03-01 00:00:00
abstract::The aims of the study were (1) to replicate previous quantitative studies of motor activity in low-risk and high-risk preterm infants and (2) to apply a new method of systematic analysis of the qualitative characteristics of general movements in these two groups of infants. Sequential one-hour videorecordings of the u...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90013-9
更新日期:1990-09-01 00:00:00
abstract::Several guidelines have been created in an attempt to raise the quality of different kinds of studies. These also attempt to ensure that research is reported accurately and transparently. Six such guidelines (CONSORT, MOOSE, PRISMA, SPIRIT, STARD, and STROBE) will be briefly discussed in this paper. The purpose of the...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.05.014
更新日期:2019-07-01 00:00:00
abstract::A multicenter randomised trial was conducted in nine neonatal centers in Japan to re-evaluate the safety and the efficacy of high frequency oscillatory ventilation using the piston type oscillator (Hummingbird) in the treatment of respiratory failure in preterm infants weighing between 750 and 2000 g at birth. A total...
journal_title:Early human development
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0378-3782(93)90088-c
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Pregnant women's sleep disturbance due to fetal movement is well known. Fetal movement is thought to be an index of fetal well-being. However, as there has never been a way to easily and reliably record fetal movement, psychophysiological studies of pregnant women's sleep disturbance and fetal well-being hav...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.03.001
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Children born preterm are at risk for developing reading difficulties and for decrements in other cognitive skills compared to children born at term. AIMS:To assess how domains of function, often negatively impacted by preterm birth, predict reading development in children born preterm and at term. STUDY D...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.01.012
更新日期:2019-03-01 00:00:00
abstract::A new protocol for structured observation of motor performance in infants, SOMP-I, was applied to 72 neonatally healthy fullterm infants at 0, 2, 4, 6 and 10 months of age. It contains 13 items, formed as ascending scales, consisting of detailed descriptions of motor performance in different body positions and body pa...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(94)01598-J
更新日期:1995-01-30 00:00:00
abstract::Lipids have physical, chemical, and physiological properties that make them important factors in human nutrition. They form a group of compounds of varied chemical nature that have the common property of being soluble in organic solvents but insoluble in water. This basic property affects their digestion, absorption, ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/s0378-3782(01)00211-0
更新日期:2001-11-01 00:00:00
abstract::Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(93)90178-w
更新日期:1993-10-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) is associated with altered lung development in human and rat. The transcription factor PPARγ, is thought to contribute to lung development. PPARγ is activated by docosahexanoic acid (DHA). One contribution of PPARγ to lung development may be its direct regulation of chromatin mod...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.08.026
更新日期:2010-12-01 00:00:00
abstract::Hepatic glucose production by glycogenolysis and gluconeogenesis is essential to maintain blood glucose levels, and the glucose-6-phosphatase system catalyses the terminal step of both pathways. Developmental delays in the postnatal up-regulation of hepatic glucose-6-phosphatase enzyme activity are common in preterm i...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2004.10.005
更新日期:2005-01-01 00:00:00
abstract::Stress due to earthquakes and other natural catastrophic events may result in a decline in the male to female ratio of newborn infants. One reason may be an increased death of male fetuses 3-5 months earlier. Another reason may relate to reduced conception of males and/or early male embryo demise 8-10 months earlier. ...
journal_title:Early human development
pub_type: 杂志文章,实务指引
doi:10.1016/j.earlhumdev.2019.104859
更新日期:2020-01-01 00:00:00
abstract::Advances in pharmacology and technology have sharply reduced mortality of extremely preterm infants at the expense of an increasing number of survivors with handicaps and disabilities. The EURONIC study among neonatal intensive care units across Europe demonstrates that treatment of infants born at the limits of viabi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.10.004
更新日期:2005-12-01 00:00:00
abstract::In 1% of monozygotic twin pregnancies, one fetus is without a heart; blood circulation is maintained by an accompanying "pump" twin. Such an acardiac condition is usually diagnosed on the basis of further malformations visible by ultrasonography. We describe a monoamniotic twin pregnancy with early growth reduction in...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00011-5
更新日期:1998-08-28 00:00:00
abstract:BACKGROUND:Tyrosine hydroxylase (TH) is a specific marker for catecholaminergic neurones. Some reports have demonstrated a decrease of TH in the Sudden Infant Death Syndrome (SIDS) compared with controls. To further investigate this, the correlation between TH and sleep apnea was investigated here. MATERIALS AND METHO...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2003.08.007
更新日期:2003-12-01 00:00:00
abstract:INTRODUCTION:The sex ratio at birth (usually denoted as M/T=male divided by total births) is influenced by cultural factors. The Chinese Zodiac holds that women born in the Fire Horse year (1966) would be unlucky. It has been shown that significantly less children were born in Japan in this year. This study was carried...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.08.011
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of several brain areas, including the cerebellum and the hippocampus. The most plausible reason for reduction would be the reduced cell formation following premature birth. However, no ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.03.004
更新日期:2004-06-01 00:00:00
abstract::Standards for Research (StaR) in Child Health, founded in 2009, addresses the current scarcity of and deficiencies in pediatric clinical trials. StaR Child Health brings together leading international experts devoted to developing practical, evidence-based standards to enrich the reliability and relevance of pediatric...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.09.011
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:This pilot study compared the physiological and behavioural changes in premature infants undergoing three different methods of screening for retinopathy of prematurity (ROP). STUDY DESIGN:Prospective randomized cross-over pilot study. SUBJECTS AND METHODS:Fifteen premature infants requiring screening for ROP ...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2004.09.005
更新日期:2005-04-01 00:00:00
abstract::Magnetic Resonance Imaging is becoming more widely available and increasingly important for imaging the neonatal brain. In newborn infants it poses challenges regarding patient preparation, safety, optimal timing, and sequence optimization. These issues are addressed in this paper and indications for performing neonat...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::Lung surfactant was obtained by postmortem lavage from: (A) premature babies: 34 dying acutely within 2 days of birth from Hyaline Membrane Disease (HMD), 20 dying several days after birth with HMD and its consequences, 8 dying from causes other than HMD; (B) mature babies: 24 dying stillborn, 15 dying soon after birt...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(88)90094-1
更新日期:1988-03-01 00:00:00
abstract::Thrombocytopenia is a very frequent problem among sick neonates, affecting up to 35% of all infants admitted to the neonatal intensive care unit (NICU), and serves as an important indicator of multiple clinical conditions. The cause of the thrombocytopenia is unclear in up to 60% of affected neonates. A clinical class...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(14)50014-X
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Non-nutritive suck (NNS) is one piece of the complex oral feeding process, yet there is paucity on how it develops throughout the first year of life. AIMS:To determine changes in infant NNS between 3 and 12 months of age. STUDY DESIGN:Twenty-six full-term infants (65% male) completed this study. All infant...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105141
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Even though the biological norm in humans is frequent on demand breastfeeding, sparse feeding intervals have become the cultural norm in most Western countries due to a history of on schedule breastfeeding. This discrepancy between the biological basis and the culturally driven practice continues to interfer...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105242
更新日期:2020-12-01 00:00:00
abstract::A comparison has been made of protein accretion and growth in premature infants fed banked drip breast milk (BBM) or a preterm formula (PF). Protein accretion was calculated from the difference between dietary nitrogen intake and output in urine and stools, measured in a nutrient balance study. As expected, only the i...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90152-5
更新日期:1985-12-01 00:00:00
abstract::Fifty-five pregnant Rhesus isoimmunized women were subjected to fetal blood sampling or fetal blood transfusion on 135 occasions. Glucose and C-peptide concentrations were measured in fetal blood, in addition to the routine investigations for complete blood count, blood gases and lactate concentration, in order to inv...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90027-g
更新日期:1990-12-01 00:00:00