Detection of 'rare event' fetal erythroblasts in maternal blood using automated microscopy.

Abstract:

:This paper describes the use of automated microscopy to detect fetal erythroblasts in maternal blood. The technology is based on the following approach: (1) the use of centrifugal cytology for the preparation of monolayers; (2) simultaneous staining of fetal hemoglobin (immunoalkaline phosphatase) and chromosome sequences (FISH); (3) multi-mode microscopy to detect rare events; (4) visual evaluation of image memories containing detected objects. Model systems show that fetal cells in frequencies as low as 1 in a million cells can be detected easily (manually or by automated microscopy). Algorithms for automated cell selection were developed for a test set of 6 patients. Optimization of hardware and software routines will make analysis of several million cells in approximately 1 h feasible.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Tanke HJ,Oosterwijk JC,Mesker WE,Ouwerkerk van-Velzen MC,Knepflé CF,Wiesmeyer CC,van Ommen GJ,Kanhai HH,Vrolijk J

doi

10.1016/s0378-3782(96)01829-4

subject

Has Abstract

pub_date

1996-12-30 00:00:00

pages

S89-93

eissn

0378-3782

issn

1872-6232

pii

S0378378296018294

journal_volume

47 Suppl

pub_type

杂志文章
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    abstract::The worst of institutional care was brought to public attention in Romania during the 1990s when pictures of severely deprived and malnourished children were shown around the world. However, many European countries have high rates of young children in institutions, where the physical care of the child predominates, wi...

    journal_title:Early human development

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    doi:10.1016/j.earlhumdev.2012.09.018

    authors: Hamilton-Giachritsis C,Browne K

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    journal_title:Early human development

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    authors: Pereira-da-Silva L,Veiga Gomes J,Clington A,Videira-Amaral JM,Bustamante SA

    更新日期:1999-03-01 00:00:00

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    journal_title:Early human development

    pub_type: 杂志文章

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    authors: Murphy DJ

    更新日期:2001-07-01 00:00:00

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    abstract::Mother's own milk is widely recognized as the optimal feeding for term infants, but also provides health benefits that are of vital importance for sick and preterm infants in neonatal intensive care units (NICUs), even though the growth and neurodevelopmental needs of very premature infants are best met by appropriate...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/j.earlhumdev.2013.07.008

    authors: Bertino E,Giuliani F,Baricco M,Di Nicola P,Peila C,Vassia C,Chiale F,Pirra A,Cresi F,Martano C,Coscia A

    更新日期:2013-10-01 00:00:00

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    abstract::Neonatal sepsis is frequently accompanied by significant and sometimes life-threatening coagulopathy. More complete understanding is needed of the molecular and cellular mechanisms underlying the interaction of the inflammatory and hemostatic systems. Such information may help focus future studies toward novel ways to...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/S0378-3782(14)70008-8

    authors: Del Vecchio A,Stronati M,Franco C,Christensen RD

    更新日期:2014-03-01 00:00:00

  • Qualitative changes of general movements in preterm infants with brain lesions.

    abstract::The aims of the study were (1) to replicate previous quantitative studies of motor activity in low-risk and high-risk preterm infants and (2) to apply a new method of systematic analysis of the qualitative characteristics of general movements in these two groups of infants. Sequential one-hour videorecordings of the u...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(90)90013-9

    authors: Ferrari F,Cioni G,Prechtl HF

    更新日期:1990-09-01 00:00:00

  • Write a Scientific Paper (WASP): Guidelines for reporting medical research.

    abstract::Several guidelines have been created in an attempt to raise the quality of different kinds of studies. These also attempt to ensure that research is reported accurately and transparently. Six such guidelines (CONSORT, MOOSE, PRISMA, SPIRIT, STARD, and STROBE) will be briefly discussed in this paper. The purpose of the...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2019.05.014

    authors: Grech V

    更新日期:2019-07-01 00:00:00

  • A multicenter randomized trial of high frequency oscillatory ventilation as compared with conventional mechanical ventilation in preterm infants with respiratory failure.

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    journal_title:Early human development

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/0378-3782(93)90088-c

    authors: Ogawa Y,Miyasaka K,Kawano T,Imura S,Inukai K,Okuyama K,Oguchi K,Togari H,Nishida H,Mishina J

    更新日期:1993-02-01 00:00:00

  • A long-term monitoring of fetal movement at home using a newly developed sensor: an introduction of maternal micro-arousals evoked by fetal movement during maternal sleep.

    abstract:BACKGROUND:Pregnant women's sleep disturbance due to fetal movement is well known. Fetal movement is thought to be an index of fetal well-being. However, as there has never been a way to easily and reliably record fetal movement, psychophysiological studies of pregnant women's sleep disturbance and fetal well-being hav...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2008.03.001

    authors: Nishihara K,Horiuchi S,Eto H,Honda M

    更新日期:2008-09-01 00:00:00

  • Predicting text reading skills at age 8 years in children born preterm and at term.

    abstract:BACKGROUND:Children born preterm are at risk for developing reading difficulties and for decrements in other cognitive skills compared to children born at term. AIMS:To assess how domains of function, often negatively impacted by preterm birth, predict reading development in children born preterm and at term. STUDY D...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2019.01.012

    authors: Borchers LR,Bruckert L,Travis KE,Dodson CK,Loe IM,Marchman VA,Feldman HM

    更新日期:2019-03-01 00:00:00

  • Structured observation of motor performance (SOMP-I) applied to neonatally healthy fullterm infants at the ages of 0-10 months.

    abstract::A new protocol for structured observation of motor performance in infants, SOMP-I, was applied to 72 neonatally healthy fullterm infants at 0, 2, 4, 6 and 10 months of age. It contains 13 items, formed as ascending scales, consisting of detailed descriptions of motor performance in different body positions and body pa...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(94)01598-J

    authors: Persson K,Strömberg B

    更新日期:1995-01-30 00:00:00

  • Absorption and distribution of dietary fatty acids from different sources.

    abstract::Lipids have physical, chemical, and physiological properties that make them important factors in human nutrition. They form a group of compounds of varied chemical nature that have the common property of being soluble in organic solvents but insoluble in water. This basic property affects their digestion, absorption, ...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-3782(01)00211-0

    authors: Ramírez M,Amate L,Gil A

    更新日期:2001-11-01 00:00:00

  • Albumin levels in pregnancy: a hypothesis--decreased levels of albumin are related to increased levels of alpha-fetoprotein.

    abstract::Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(93)90178-w

    authors: Maher JE,Goldenberg RL,Tamura T,Cliver SP,Hoffman HJ,Davis RO,Boots L

    更新日期:1993-10-01 00:00:00

  • IUGR decreases PPARγ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation.

    abstract::Intrauterine growth restriction (IUGR) is associated with altered lung development in human and rat. The transcription factor PPARγ, is thought to contribute to lung development. PPARγ is activated by docosahexanoic acid (DHA). One contribution of PPARγ to lung development may be its direct regulation of chromatin mod...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2010.08.026

    authors: Joss-Moore LA,Wang Y,Baack ML,Yao J,Norris AW,Yu X,Callaway CW,McKnight RA,Albertine KH,Lane RH

    更新日期:2010-12-01 00:00:00

  • Glucose homeostasis in the newborn.

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    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/j.earlhumdev.2004.10.005

    authors: Hume R,Burchell A,Williams FL,Koh DK

    更新日期:2005-01-01 00:00:00

  • Effects of earthquakes and other natural catastrophic events on the sex ratio of newborn infants.

    abstract::Stress due to earthquakes and other natural catastrophic events may result in a decline in the male to female ratio of newborn infants. One reason may be an increased death of male fetuses 3-5 months earlier. Another reason may relate to reduced conception of males and/or early male embryo demise 8-10 months earlier. ...

    journal_title:Early human development

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.earlhumdev.2019.104859

    authors: Fukuda M,Fukuda K,Mason S,Shimizu T,Andersen CY

    更新日期:2020-01-01 00:00:00

  • Withholding treatment, withdrawing treatment, and palliative care in the neonatal intensive care unit.

    abstract::Advances in pharmacology and technology have sharply reduced mortality of extremely preterm infants at the expense of an increasing number of survivors with handicaps and disabilities. The EURONIC study among neonatal intensive care units across Europe demonstrates that treatment of infants born at the limits of viabi...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2005.10.004

    authors: Walther FJ

    更新日期:2005-12-01 00:00:00

  • Cardiac regression sequence: reversal of blood flow is diagnostic but not causative in an acardiac fetus.

    abstract::In 1% of monozygotic twin pregnancies, one fetus is without a heart; blood circulation is maintained by an accompanying "pump" twin. Such an acardiac condition is usually diagnosed on the basis of further malformations visible by ultrasonography. We describe a monoamniotic twin pregnancy with early growth reduction in...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/s0378-3782(98)00011-5

    authors: Ersch J,Stallmach T

    更新日期:1998-08-28 00:00:00

  • Catecholaminergic neurons in the brain-stem and sleep apnea in SIDS victims.

    abstract:BACKGROUND:Tyrosine hydroxylase (TH) is a specific marker for catecholaminergic neurones. Some reports have demonstrated a decrease of TH in the Sudden Infant Death Syndrome (SIDS) compared with controls. To further investigate this, the correlation between TH and sleep apnea was investigated here. MATERIALS AND METHO...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2003.08.007

    authors: Sawaguchi T,Ozawa Y,Patricia F,Kadhim H,Groswasser J,Sottiaux M,Takashima S,Nishida H,Kahn A

    更新日期:2003-12-01 00:00:00

  • The Japanese male: Female birth ratio rose in the 1966 Fire-Horse year due to female birth year misrepresentation.

    abstract:INTRODUCTION:The sex ratio at birth (usually denoted as M/T=male divided by total births) is influenced by cultural factors. The Chinese Zodiac holds that women born in the Fire Horse year (1966) would be unlucky. It has been shown that significantly less children were born in Japan in this year. This study was carried...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2016.08.011

    authors: Grech V

    更新日期:2016-12-01 00:00:00

  • Cell proliferation correlates with the postconceptual and not with the postnatal age in the hippocampal dentate gyrus, temporal neocortex and cerebellar cortex of preterm infants.

    abstract:BACKGROUND:In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of several brain areas, including the cerebellum and the hippocampus. The most plausible reason for reduction would be the reduced cell formation following premature birth. However, no ...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2004.03.004

    authors: Abrahám H,Tornóczky T,Kosztolányi G,Seress L

    更新日期:2004-06-01 00:00:00

  • StaR Child Health: improving global standards for child health research.

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    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2013.09.011

    authors: Offringa M,Needham AC,Chan WW,StaR Child Health group.

    更新日期:2013-11-01 00:00:00

  • Pilot study of the systemic effects of three different screening methods used for retinopathy of prematurity.

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    journal_title:Early human development

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.earlhumdev.2004.09.005

    authors: Mehta M,Adams GG,Bunce C,Xing W,Hill M

    更新日期:2005-04-01 00:00:00

  • Magnetic resonance imaging of the brain in newborn infants: practical aspects.

    abstract::Magnetic Resonance Imaging is becoming more widely available and increasingly important for imaging the neonatal brain. In newborn infants it poses challenges regarding patient preparation, safety, optimal timing, and sequence optimization. These issues are addressed in this paper and indications for performing neonat...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/j.earlhumdev.2008.11.009

    authors: van Wezel-Meijler G,Leijser LM,de Bruïne FT,Steggerda SJ,van der Grond J,Walther FJ

    更新日期:2009-02-01 00:00:00

  • Pulmonary surfactant. I. In immature and mature babies.

    abstract::Lung surfactant was obtained by postmortem lavage from: (A) premature babies: 34 dying acutely within 2 days of birth from Hyaline Membrane Disease (HMD), 20 dying several days after birth with HMD and its consequences, 8 dying from causes other than HMD; (B) mature babies: 24 dying stillborn, 15 dying soon after birt...

    journal_title:Early human development

    pub_type: 杂志文章

    doi:10.1016/0378-3782(88)90094-1

    authors: Hill CM,Brown BD,Morley CJ,Davis JA,Barson AJ

    更新日期:1988-03-01 00:00:00

  • Evaluation and management of thrombocytopenic neonates in the intensive care unit.

    abstract::Thrombocytopenia is a very frequent problem among sick neonates, affecting up to 35% of all infants admitted to the neonatal intensive care unit (NICU), and serves as an important indicator of multiple clinical conditions. The cause of the thrombocytopenia is unclear in up to 60% of affected neonates. A clinical class...

    journal_title:Early human development

    pub_type: 杂志文章,评审

    doi:10.1016/S0378-3782(14)50014-X

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    更新日期:2014-09-01 00:00:00

  • Changes in non-nutritive suck between 3 and 12 months.

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    pub_type: 杂志文章

    doi:10.1016/j.earlhumdev.2020.105141

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    更新日期:2020-10-01 00:00:00

  • A breastfeeding support program changed breastfeeding patterns but did not affect the mothers' self-efficacy in breastfeeding at two months.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1016/0378-3782(85)90152-5

    authors: Roberts SB,Lucas A

    更新日期:1985-12-01 00:00:00

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    abstract::Fifty-five pregnant Rhesus isoimmunized women were subjected to fetal blood sampling or fetal blood transfusion on 135 occasions. Glucose and C-peptide concentrations were measured in fetal blood, in addition to the routine investigations for complete blood count, blood gases and lactate concentration, in order to inv...

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    pub_type: 杂志文章

    doi:10.1016/0378-3782(90)90027-g

    authors: Stangenberg M,Sasidharan P

    更新日期:1990-12-01 00:00:00