Abstract:
:The aims of the study were (1) to replicate previous quantitative studies of motor activity in low-risk and high-risk preterm infants and (2) to apply a new method of systematic analysis of the qualitative characteristics of general movements in these two groups of infants. Sequential one-hour videorecordings of the unstimulated infants in the incubator were made during the preterm period and then continued during the postterm period until about 20 weeks. The high-risk group consisted only of infants with signs of haemorrhage and/or leucomalacia in the repeated ultrasonograms of the brain. The neurological follow-up continued up to a minimum of one and a maximum of three years of corrected age. The quantification of the various motor patterns in 12 matched pairs of low-risk and high-risk preterm infants revealed a slight but significant (P = 0.05) excess of isolated arm movements in the low-risk cases during the activity phase. No other movement pattern differed significantly. The qualitative assessment of general movements during the preterm period resulted in all but one of the 14 low-risk cases having a normal quality of general movements. In the lesion-group (N = 29) all the infants had an abnormal quality during the preterm period. Eight cases later became neurologically normal although 1 of them had strabism. In addition, one infant was blind (ROP) and retarded and one other had mental retardation. Nineteen infants later developed cerebral palsy (two monoplegia of a leg, three hemiplegia, 5 diplegia and 9 quadriplegia). Strabism was present in 48.3% of the whole group of 29 cases. A semi-quantitative estimation of various aspects of the abnormal general movements made a typology of abnormal patterns possible. A graphic display of developmental trajectories of individual cases, depicting the course of abnormal aspects along the time axis, helps document the evolution of abnormal signs. Their course is a better predictor of the neurological outcome than the nature and localization of the lesion, detected by imaging techniques. The qualitative assessment of general movements from videorecordings is a reliable, quick, cheap and totally non-intrusive method in neonatology for the early detection of functional impairment of the nervous system.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Ferrari F,Cioni G,Prechtl HFdoi
10.1016/0378-3782(90)90013-9subject
Has Abstractpub_date
1990-09-01 00:00:00pages
193-231issue
3eissn
0378-3782issn
1872-6232pii
0378-3782(90)90013-9journal_volume
23pub_type
杂志文章abstract:BACKGROUND:Bright constant light levels in the NICU may have negative effects on the growth and development of preterm infants OBJECTIVE:The aim of this study is to evaluate the benefits of an alternating light/dark cycle in the NICU on weight gain and early discharge from the therapy in premature infants. PATIENTS A...
journal_title:Early human development
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.earlhumdev.2014.04.015
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND AIM:Swaddling is a well-known technique in developmental care programs as there is some evidence that swaddling is an appropriate stress-reducing method for preterm infants in the NICU. However, no experimental study has investigated the influence of swaddling in a learning context. This study aimed to a...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105288
更新日期:2021-02-01 00:00:00
abstract::Data on the postnatal growth patterns of 238 small-for-gestational age (SGA) and 241 large-for-gestational age (LGA) babies are presented. Three proportionality ratios were selected; and their changes in shape, by these indices, during the first 7 years are compared with a random sample of 284 children drawn from the ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(86)90095-2
更新日期:1986-02-01 00:00:00
abstract::Spectral analysis was performed on ventilation and instantaneous heart rate data recorded in 15 term infants during quiet sleep in the first week after delivery, and in 11 of these infants during active sleep. There was a close relation between the main peaks of the ventilation spectra and the corresponding histograms...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(89)90050-9
更新日期:1989-11-01 00:00:00
abstract::To precisely measure the events of the fetal breath cycle it is necessary to have an accurate hard copy record. Two approaches to this have been made using either M-mode or Doppler ultrasound. It was the aim of this paper to compare these methods. Hard copy records of fetal breathing movements were produced by simulta...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(89)90010-8
更新日期:1989-12-01 00:00:00
abstract::Among 7 subjects with hyperemesis gravidarum (HG), we found gabapentin therapy to be associated with mean reductions in nausea and emesis from Baseline to Days 12-14 of 80% and 94%, respectively. There have been 2 congenital defects among 7 exposed infants. Gabapentin may be effective in the treatment of HG. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2009.11.003
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The interaction between the infant and the caregiver is stated to be very important in the development of a child. When there is inadequacy of interaction, several emotional and developmental problems can emerge. We aimed to investigate the socio-demographic and clinical features of children diagnos...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.09.004
更新日期:2012-06-01 00:00:00
abstract::Altogether 2159 pregnancies among black and white Americans in the Collaborative Perinatal Study and dental casts from the children at the age of 5-12 years were studied to find out the effect of maternal smoking on deciduous tooth crown growth. Minor crown size reduction (2-3%) in some dimensions was found in childre...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90086-v
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:There have been few research studies aimed at obtaining a better understanding of the prediction of subsequent respiratory morbidity at follow-up in infants with a previous history of bronchopulmonary dysplasia (BPD) living in low- and middle-income countries (LMIC). The aim of the present study was to ident...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2018.10.003
更新日期:2018-12-01 00:00:00
abstract::The reactions of heart rate (HR), systolic (sBP) and diastolic (dBP) blood pressure were studied in response to passive head-up tilting (successively to +45 degrees and +90 degrees) in a group of 83 full-term, 1- to 7-day-old newborns who were quiet and awake. A significant mean increase of HR was noted for the whole ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01706-2
更新日期:1996-03-22 00:00:00
abstract::The anatomical findings of sirenomelia in a 12-weeks aborted embryo are reported. The occurrence of sirenomelia in material from spontaneous abortions is discussed. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(87)90080-6
更新日期:1987-07-01 00:00:00
abstract::Twenty-eight very low birth weight (VLBW) and 32 full term infants were prospectively assessed at one year of age for hearing, language development and neurological status. The prevalence of conductive hearing deficits was the same in both groups. Language scores in VLBW infants were significantly lower than in fullte...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90007-6
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Controversial results have been reported on the effect of type of feeding on the level of fecal calprotectin in infants. OBJECTIVE:To assess fecal calprotectin levels in breast fed or nonbreast fed healthy infants. DESIGN:A study was conducted to compare fecal calprotectin in infants who were exclusively b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.06.005
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To assess the applicability of Drotar model when the diagnosis of congenital malformation is made antenatally. METHODS:In a 3-year period (2000-2003) fifty mothers, counselled for fetal malformations amenable to surgical correction at birth, were interviewed. Statistical associations were sought between each...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.12.010
更新日期:2006-10-01 00:00:00
abstract::The purpose of this study was to compare two different methods for assessing fetal heart rate (FHR)--fetal eye movement (FEM) synchronization: (1) periods of high (HV) and low (LV) variability in the FHR and the presence (EM) and absence (NEM) of FEM were determined by visual inspection and the degree of association b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90137-6
更新日期:1992-09-01 00:00:00
abstract::We have shown for the first time that the microsomal glucose-6-phosphatase enzyme protein is present in human embryonic and fetal red blood cells and the ontogeny of its expression has been determined. In the earliest embryos, red cells are predominantly of the primitive megaloblastic type. Circulating red cells in th...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01626-e
更新日期:1995-06-21 00:00:00
abstract:BACKGROUND:At present, the diagnosis of pulmonary hypoplasia is based on postmortem findings, and there are no clear clinical diagnostic criteria to facilitate its identification and management. AIM:To characterise the respiratory status of pulmonary hypoplasia syndrome (PHS) following preterm rupture of membranes so ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2003.07.002
更新日期:2004-08-01 00:00:00
abstract::Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00077-2
更新日期:1999-01-01 00:00:00
abstract::Newborn infants, especially preterm infants, have an immature immune system, which is not capable to actively protect against vaccine-preventable infections. Therefore, the newborn is dependent on transplacental transport of Immunoglobulin G (IgG), an active, FcRn receptor mediated process. Fetal IgG rises from approx...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2010.11.003
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To determine whether placental lesions are risk factors for neurologic morbidities in intrauterine growth restricted (IUGR) infants, we compared the incidence of cranial ultrasound (CUS) abnormalities and the number and type of placental lesions in IUGR cases and gestational age-matched appropriate for gestat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(01)00114-1
更新日期:2001-04-01 00:00:00
abstract::The presence of dilated bowel loops antenatally suggests fetal bowel obstruction. Neonatal intestinal obstruction can have different variations in presentation depending on the level and extent of obstruction. Some of these conditions can be diagnosed antenatally. Antenatal detection of surgically correctable anomalie...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2006.02.005
更新日期:2006-05-01 00:00:00
abstract::A multicenter randomised trial was conducted in nine neonatal centers in Japan to re-evaluate the safety and the efficacy of high frequency oscillatory ventilation using the piston type oscillator (Hummingbird) in the treatment of respiratory failure in preterm infants weighing between 750 and 2000 g at birth. A total...
journal_title:Early human development
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0378-3782(93)90088-c
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are prescribed in 2-8% during pregnancy. Whether prenatal exposure to SSRIs has long-term effects on the children's development is unknown. AIM:The aim of this study was to determine the effect of prenatal exposure to SSRIs on children's cognitive, motor, and ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105075
更新日期:2020-08-01 00:00:00
abstract::The influence of lung function and reflex activity on the success of patient-triggered ventilation (PTV) has been determined. Lung function was assessed by measurement of compliance using a single breath technique. Reflex activity was assessed by measurement of the strength of Hering Breuer reflex indicated by the deg...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(94)90142-2
更新日期:1994-04-30 00:00:00
abstract:BACKGROUND:Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm. AIM:To estimate the risk of attention problems at age 10years in children born very preterm to overweight ...
journal_title:Early human development
pub_type: 杂志文章,多中心研究
doi:10.1016/j.earlhumdev.2017.08.002
更新日期:2017-12-01 00:00:00
abstract::Neonatal hyperglycaemia is a frequent complication in VLBW infants during the first week of life. The more common causes include high glucose intake, stress situations such as sepsis, NEC, and surgical treatments, as well as the administration of vasoactive drugs and methylxanthines. The appropriate definition is uncl...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2011.01.005
更新日期:2011-03-01 00:00:00
abstract::Management of neonatal hydronephrosis is a clinical challenge. The natural history of hydronephrosis has shown that most resolve spontaneously; however, there are a significant number that do not. Although hydronephrosis does not always mean obstruction, it becomes the clinician's role to determine when obstruction wi...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2005.11.004
更新日期:2006-01-01 00:00:00
abstract::221 small-for-dates (SFD) and 244 average-for-dates (AFD) children were personally examined at birth, and seen thereafter at regular intervals up to 4 years, when a thorough assessment was made. There was an excess of SFD children with major congenital abnormalities; but no difference between the groups in the number ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(83)90007-5
更新日期:1983-10-01 00:00:00
abstract:INTRODUCTION:Little is known about sex differences in human fetal heart and behaviour. PATIENTS AND METHODS:One hundred twenty-three nulliparous healthy women carrying a male (n=56) or female (n=67) fetus participated in this study. All pregnancies remained uncomplicated and delivery was uneventful. Ultrasound observa...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(03)00047-1
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2003.08.017
更新日期:2003-12-01 00:00:00