Abstract：
BACKGROUND:In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of several brain areas, including the cerebellum and the hippocampus. The most plausible reason for reduction would be the reduced cell formation following premature birth. However, no data are available about the rate of postnatal cell proliferation in the different brain areas of preterms. METHODS:Cytoarchitectonics and cell proliferation were examined in the cerebellum, hippocampal formation and temporal neocortex of preterm infants who lived for several weeks or months. Cell proliferation was detected with Ki-67 immunostaining and proliferating cells were identified with vimentin as glial and with CD31 and periodic acid-Schiff (PAS) reaction as endothelial elements. RESULTS:The rate of cell formation and the width of the cytoarchitectonic layers of the cerebellum of preterm infants corresponded to that of the age-matched controls. In the hippocampal dentate gyrus, the rate of cell formation and the density of proliferating cells were slightly higher in the preterm infants than in the full-term age-matched controls. Endothelial cell proliferation and the surface area of the capillaries were larger in the dentate gyrus of preterms than in age-matched controls. CONCLUSION:Rate of cell proliferation that correlates with the postconceptual age is not reduced in preterms, therefore the reduced size of the cerebellum and hippocampal formation is unlikely to be the result of decreased cell formation.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Abrahám H,Tornóczky T,Kosztolányi G,Seress Ldoi
10.1016/j.earlhumdev.2004.03.004keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
29-43issue
1eissn
0378-3782issn
1872-6232pii
S037837820400026Xjournal_volume
78pub_type
杂志文章abstract：:Pulse oximetry screening for critical congenital heart defects (CCHDs) is a highly specific, moderately sensitive test which is cost effective, acceptable to both clinical staff and parents and meets the criteria for universal screening. Pulse oximetry screening is gaining considerable worldwide support and last year ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.09.013
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abstract：:During the period 1978-1990 (12.5 years), 929 neonatal general surgical emergencies were treated at the Seoul National University Children's Hospital. There were 308 anorectal malformations, 128 atresia/stenosis of the gut, 125 neonatal Hirschsprung's disease, 75 gastroschisis and 67 esophageal atresias. The highest o...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90194-l
更新日期：1992-06-01 00:00:00
abstract：:The study set out to document child care practices in as many different countries and cultures as possible with the aim of providing baseline child care data and stimulating new hypotheses to explain persisting differences in sudden infant death syndrome (SIDS) rates between countries. The protocol, piloted in four co...
journal_title：Early human development
pub_type： 杂志文章,多中心研究
doi：10.1016/s0378-3782(99)00021-3
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Acidemia at birth is very common but little is known about its long-term consequences. AIM:To determine if pH at birth is related to established tests of intellectual function. SUBJECTS:School children aged 6-8, for whom obstetric data were available, who had been delivered after labour at term, and had an...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.02.002
更新日期：2008-01-01 00:00:00
abstract：:Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life. Gastro-oesophageal reflux may be a primary gastro-intestinal motility disorder, but it may also be secondary to other conditions such as cow's milk protein allergy. Objective diagnosis can be ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.10.011
更新日期：2005-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90117-8
更新日期：1984-09-01 00:00:00
abstract：:Fifty-one British newborn infants and 51 Japanese newborn infants were compared using Prechtl's neonatal neurological examination and Brazelton's neonatal behavioural assessment scale on the 5th day after birth. Statistically significant differences were found between the two groups. British infants were more responsi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90172-d
更新日期：1992-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.10.003
更新日期：2018-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90062-3
更新日期：1985-01-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90070-4
更新日期：1989-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90110-5
更新日期：1984-09-01 00:00:00
abstract：:The influence of lung function and reflex activity on the success of patient-triggered ventilation (PTV) has been determined. Lung function was assessed by measurement of compliance using a single breath technique. Reflex activity was assessed by measurement of the strength of Hering Breuer reflex indicated by the deg...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90142-2
更新日期：1994-04-30 00:00:00
abstract：:The reported energy content of infant formulas will vary, depending upon the method used to calculate or measure the caloric value. Manufacturers' specifications regarding the energy content of milk formulas reflects the 'metabolizable' energy. i.e., the amount of energy which is digested and absorbed by the infant. H...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90124-4
更新日期：1982-07-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.10.007
更新日期：2009-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2010.01.008
更新日期：2010-07-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105137
更新日期：2020-09-01 00:00:00
abstract：:Posture and spontaneous motor patterns during the first days of life were studied in ten healthy fullterm infants by direct observation and videorecording. The aim of the study was to provide a description of motor and postural characteristics of normal newborns. The infants were recorded for 1 h on their first and fo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90020-0
更新日期：1989-02-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.06.009
更新日期：2015-09-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：1998-01-09 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
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更新日期：2014-03-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(81)90034-7
更新日期：1981-07-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.08.017
更新日期：2010-10-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90115-j
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Children born preterm are at risk of visuospatial attention orienting and processing dysfunctions, which can be quantified early in life using visually-guided eye movement responses. AIMS:To identify the prevalence and perinatal risk factors for visuospatial attention orienting and processing dysfunctions i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.01.015
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Previous studies suggest that RhD positive heterozygotes express better health status than RhD positive homozygotes and especially RhD negative subjects. This also applies to pregnant women. According to the Trivers-Willard hypothesis, women in better physical condition should have more sons. AIM:To test th...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2019.104864
更新日期：2020-01-01 00:00:00
abstract：:Fifty-five pregnant Rhesus isoimmunized women were subjected to fetal blood sampling or fetal blood transfusion on 135 occasions. Glucose and C-peptide concentrations were measured in fetal blood, in addition to the routine investigations for complete blood count, blood gases and lactate concentration, in order to inv...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90027-g
更新日期：1990-12-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105074
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Preterm infants have a higher risk of language delay throughout childhood. The ability to integrate audiovisual speech information is associated with language acquisition in term infants; however, the relation is still unclear in preterm infant. AIM AND METHODS:This study longitudinally investigated visual ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:There is concern that exposure of preterm infants to noxious insults over a prolonged period may have long term effects on their developing nervous system. AIMS:To investigate medium and long term effects of heel pricks in infants over the first year of life. STUDY DESIGN:Study 1-a longitudinal study, 2 da...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.09.018
更新日期：2008-06-01 00:00:00
