Abstract：
:Ultrastructural and immunohistochemical studies were made of the testicular interstitial tissue from eight human fetuses of 15 to 27 weeks gestation. Three cell types developed in mesenchymal cells: Leydig cells and peritubular cells, as already reported, and cells of the mononuclear phagocyte system (MPS), which are located in the intermediate area of the interstitial tissue. Located at the periphery of Leydig cells, these gradually differentiate between 16 and 20 weeks and later acquire the ultrastructural characteristic of histiocytes during the involution phase of the fetal testis. Immunohistochemical studies using monoclonal antibodies (Mo Ab) to antigens of human myelomonocytic cells isolated a cell subpopulation in the interstitial tissue that is distinct from the peritubular (fibroblastic) and the Leydig cells. This subpopulation expressed all or some of these antigens according to their stage of differentiation; all cells are labelled by MY7 Mo Ab which is directed against myelomonocytic cells, including stem cell. Using monoclonal antibodies directed against more mature cells (MY4, MO1 and MO2), the number of labelled cells decreased in this mesenchymal population. MY4 Mo Ab, which detect myelomonocytic cells excluding stem cell, label fewer than MY7 Mo Ab. MO1 MO Ab and MO2 Mo Ab, respectively, directed against antigens of more mature or mature monocytic cells, label less number of mesenchymal cells, which are histiocytes after 20 weeks. These ultrastructural and immunohistochemical findings suggest that cells of the MPS differentiate within the interstitium.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Dechelotte P,Chassagne J,Labbe A,Afane M,Scheye T,De Laguillaumie B,Boucher Ddoi
10.1016/0378-3782(89)90070-4subject
Has Abstractpub_date
1989-09-01 00:00:00pages
25-36issue
1eissn
0378-3782issn
1872-6232pii
0378-3782(89)90070-4journal_volume
20pub_type
杂志文章abstract：:The structural changes in the umbilical cord of full term fetuses from 18 cases of gestational diabetes were studied. All these were insulin-dependent and their blood glucose levels were well controlled. Light microscopy showed rupture and erosion of the endothelial lining of umbilical arteries resulting in increased ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90114-3
更新日期：1986-10-01 00:00:00
abstract：:A method has been developed for long-term continuous recordings of several physiological variables in humans, including body movements, core temperature, heart rate and respiratory rate. This method enabled us to study circadian rhythms of body temperature and rest-activity in preterm infants. In 5 out of 9 infants (r...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90137-8
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Several studies report increased minor neurodevelopment dysfunctions in children born very low birth weight (VLBW). Usefulness of preventive early intervention programs to improve neurodevelopment outcome of VLBW infants is still under investigation. AIMS:To evaluate the effects of an early post-discharge d...
journal_title：Early human development
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.earlhumdev.2006.01.011
更新日期：2006-10-01 00:00:00
abstract：:The biochemical, dermatological and neurological motor disorders of biotinidase deficiency (multiple carboxylase deficiency) show a dramatic response to pharmacological doses of biotin. This condition is characterised by the accumulation of biocytin and depletion of biotin. Neuromuscular function returns to normal wit...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90086-6
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND:Among preterm infants, high concentrations of inflammatory mediators in cerebrospinal fluid (CSF) are associated with poor outcome. Previous studies have not indicated whether CSF concentrations of inflammatory mediators are associated with important confounders such as gestational age. AIMS:To examine asso...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.10.011
更新日期：2009-04-01 00:00:00
abstract：:CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosis and treatment of congenita...
journal_title：Early human development
pub_type： 杂志文章,实务指引
doi：10.1016/j.earlhumdev.2011.08.021
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis....
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.09.010
更新日期：2006-04-01 00:00:00
abstract：:Phosphatidylcholine (PC) is the predominant phospholipid in natural surfactant preparations. A metabolic intermediate, lyso-PC, is potentially injurious to the lungs. In the present study, tracheal aspirates from preterm babies with respiratory distress syndrome treated with surfactant were examined for the presence o...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(97)01885-9
更新日期：1997-09-19 00:00:00
abstract：BACKGROUND:Cognitive, behavioral, and learning problems are evident in extremely preterm/extremely low birth weight (EPT/ELBW, <28 weeks gestational age or <1000 g) children by early school age. However, we know little about how they function within the classroom once they start school. AIMS:To determine how EPT/ELBW ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.09.011
更新日期：2014-12-01 00:00:00
abstract：:Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00077-2
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To identify obstetric risk factors and to elucidate the effect of prolonged rupture of the membranes on the development of cystic periventricular leukomalacia (PVL) in preterm infants. METHODS:A retrospective case-control study of 95 preterm infants with the diagnosis of PVL and 245 healthy controls matched ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.07.007
更新日期：2009-03-01 00:00:00
abstract：:Near infra-red spectroscopy (NIRS) is a comparatively new method for monitoring the oxygenation in blood and tissue in the brain of the fetus and the neonate. Absorption of light in the wavelength range 700-1000 nm through such tissue is measured, which is then used to calculate changes in the concentration of cerebra...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90163-b
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Children born preterm are known to be at risk for neurodevelopmental disorders. The role of perinatal asphyxia in this increased risk is still a matter of debate. AIM:To analyze the contribution of perinatal asphyxia in a population of preterm infants admitted to a secondary paediatric setting to neurologic...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.06.003
更新日期：2010-07-01 00:00:00
abstract：:This project aimed to assess the accuracy of Tempa-DOT and FeverScan for measuring children's temperatures. Tempa-DOT is a small flat chemical thermometer with 50 dots that change colour at specific temperatures. FeverScan is a liquid crystal strip thermometer with temperature sensitive colour bars that change colour ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00050-4
更新日期：1998-12-01 00:00:00
abstract：:No statistically significant relationships were observed between the red blood cell acid phosphatase polymorphism (ACP-1) and birth weight, duration of gestation and proportion of preterm infants in a large series of newborn infants (greater than 8000) in Cardiff. These results are contrasted with those of a similar, ...
journal_title：Early human development
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:There is a lack of standardized echocardiographic parameters to quantify ventricular function in newborn infants. Long-axis systolic ventricular shortening is a useful parameter of global ventricular function. AIMS:Serial assessment of long-axis systolic atrioventricular annulus excursion in premature infan...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.09.006
更新日期：2013-12-01 00:00:00
abstract：:Discrepancies between active and passive muscle power are often seen in pre-term infants over the first year. Generally of a transient nature, they are most obvious in the extensor muscles of the trunk where there is a high active muscle power relative to the passive component. While high active muscle power may not b...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01661-l
更新日期：1995-08-30 00:00:00
abstract：AIM:To determine whether maternal state and trait anxiety levels affect fetal movements or fetal heart rate (FHR) in the third trimester. SUBJECTS:Forty-one healthy pregnant nulliparous women not on medication and with a singleton pregnancy. STUDY DESIGN:Maternal anxiety was assessed using the Spielberger State- Trai...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(01)00256-0
更新日期：2002-04-01 00:00:00
abstract：:The objectives of this study were (1) to detect vasoactive intestinal polypeptide in fetal blood obtained by cordocentesis (2) to examine possible changes in growth retarded fetuses and to establish relationships between its levels and fetal blood acid-base status as well as fetal haemodynamics as assessed by Doppler ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)01610-2
更新日期：1995-03-17 00:00:00
abstract：BACKGROUND:The entorhinal cortex serves as an important gateway between the cerebral cortex and the hippocampus by receiving afferent information from limbic, modality sensory-specific, and multimodal association fibers from all the brain lobes. AIM:To investigate whether thinning of entorhinal cortex is associated wi...
journal_title：Early human development
pub_type： 临床试验,杂志文章
doi：10.1016/j.earlhumdev.2011.07.017
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To assess the applicability of Drotar model when the diagnosis of congenital malformation is made antenatally. METHODS:In a 3-year period (2000-2003) fifty mothers, counselled for fetal malformations amenable to surgical correction at birth, were interviewed. Statistical associations were sought between each...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.12.010
更新日期：2006-10-01 00:00:00
abstract：:Prior research in newborns has shown that head-up and head-down tilting elicits sustained increases and decreases in heart rate, respectively. Other studies in older infants have suggested that the pattern of heart rate responses to head-up tilting varies with risk for sudden infant death syndrome (SIDS). In this stud...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00026-2
更新日期：1999-07-01 00:00:00
abstract：:The essential fatty acid (EFA) composition of umbilical vessel walls is increasingly being studied as a longer-term reflection of the fetal EFA status. We evaluated the EFA content of umbilical artery and vein vessel walls in 43 preterm infants and compared it with that of 43 full-term cord vessels. In addition, relat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01656-n
更新日期：1995-08-18 00:00:00
abstract：:Advances in pharmacology and technology have sharply reduced mortality of extremely preterm infants at the expense of an increasing number of survivors with handicaps and disabilities. The EURONIC study among neonatal intensive care units across Europe demonstrates that treatment of infants born at the limits of viabi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.10.004
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Children with major anatomical congenital anomalies (CA) often need prolonged hospitalization with surgical interventions in the neonatal period and thereafter. Better intensive care treatment has reduced mortality rates, but at the cost of more morbidity. AIM:To study motor-function and exercise capacity i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.06.014
更新日期：2010-08-01 00:00:00
abstract：:Twenty-seven 5--8-day-old babies were filmed during normal breast feeding (one feed each). Sucking patterns were determined from the film from a total sample of 17,676 sucks. Intersuck interals fell on two distributions: one of intervals between sucks during bursts of sucking (1.3 sec and less), and the other of rests...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90042-2
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND:cardiac arrhythmias are commonly observed in the fetus, however, may have major consequences for fetal development and post natal life. AIMS:to evaluate the perinatal management and cardiac outcome of fetuses with tachy- or bradyarrhythmia. STUDY DESIGN:perinatal management, outcome and long-term cardiac f...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.11.001
更新日期：2011-02-01 00:00:00
abstract：:Ninety five placentae from normal term and 'normal' preterm pregnancies have been analysed by morphometry. The growth of the whole placenta, of the microscopic placental constituents and of the villous surface area has been measured in placentae from uncomplicated pregnancies from 10 weeks of gestation to term to prov...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90074-4
更新日期：1984-06-01 00:00:00
abstract：:The relationship between blood glucose and body physique of 233 (42 hypo-and 191 normologycemic) intrauterine growth-retarded neonates was analyzed using different body measurements and indices of body proportions. Classification by combination of weight and length deficit for fetal age revealed that the disproportion...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(77)90027-5
更新日期：1977-10-01 00:00:00
abstract：:Although official guidelines for diagnosis and treatment of bronchopulmonary dysplasia (BPD) exist in Germany the practice in tertiary care neonatology centres differs considerably. There is no consensus about the appropriate level of oxygen saturation for infants at risk for BPD or infants with established BPD. Targe...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.12.004
更新日期：2005-02-01 00:00:00
