Abstract:
:Little is known about thrombopoietin (Tpo) production in human fetuses and neonates. As a step toward determining whether Tpo is relevant to platelet production in the fetus and neonate, we hypothesized that: (1) like other cytokines, Tpo is present in the cord blood in higher concentrations than in adult plasma; (2) Tpo and its receptor (c-mpl) are expressed in fetuses at, and following, 5-6 weeks post-conception (when platelet production begins); and (3) the sites of Tpo and c-mpl production in the fetus are similar to those of adults. We quantified Tpo, by ELISA, in the plasma of 50 adults, as well as in the umbilical cord plasma of 50 preterm and term infants. We also characterized, by RT-PCR, the organ distribution of Tpo and c-mpl during fetal development (at 8 and 16 weeks). Tpo concentrations were measurable (> or =41 pg/ml) in only two of the 50 adult samples (44 and 46 pg/ml), but in 24 of the 50 cord plasma samples (of the 24 samples, the median was 62 pg/ml; mean+/-SD, 80+/-39 pg/ml). Tpo levels did not correlate with either gestational age or platelet count at birth. Similarly to adults, in the fetal tissues, Tpo transcripts were found in all organs tested, but the most dense bands were from liver. C-mpl transcripts were also predominantly from liver. We conclude that: (1) Tpo is present in higher concentrations in cord plasma than in venous plasma of adults; (2) Tpo and c-mpl transcripts are detected in human fetuses as early as the onset of platelet appearance; and(3) Tpo and c-mpl have a similar organ distribution in fetuses and adults.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Sola MC,Juul SE,Meng YG,Garg S,Sims P,Calhoun DA,Dame JB,Christensen Ddoi
10.1016/s0378-3782(98)00077-2keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
239-50issue
3eissn
0378-3782issn
1872-6232pii
S0378378298000772journal_volume
53pub_type
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journal_title:Early human development
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更新日期:2008-06-01 00:00:00
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journal_title:Early human development
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更新日期:1986-02-01 00:00:00
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更新日期:2021-01-22 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(93)90100-9
更新日期:1993-12-15 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/s0378-3782(01)00211-0
更新日期:2001-11-01 00:00:00
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journal_title:Early human development
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更新日期:2013-06-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.10.009
更新日期:2013-05-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
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journal_title:Early human development
pub_type: 杂志文章,实务指引,评审
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更新日期:2008-08-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.06.003
更新日期:2011-12-01 00:00:00
abstract::Maternal milk four days post partum contained immunoreactive calcitonin in concentrations which were 22-89 times higher than those noted in concomitantly sampled maternal sera. Neurotensin-like immunoreactivity was barely detectable in milk. It is suggested that calcitonin may be a prerequisite for the concentration o...
journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1996-03-22 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2009.09.003
更新日期:2009-11-01 00:00:00
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journal_title:Early human development
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更新日期:2000-05-01 00:00:00
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journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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