Abstract：
OBJECTIVE:To identify obstetric risk factors and to elucidate the effect of prolonged rupture of the membranes on the development of cystic periventricular leukomalacia (PVL) in preterm infants. METHODS:A retrospective case-control study of 95 preterm infants with the diagnosis of PVL and 245 healthy controls matched for gestational age. A total of 52 antenatal, intrapartum and neonatal characteristics were studied by univariate methods and logistic regression. RESULTS:Preterm premature rupture of membranes (PPROM) (odds ratio 2.1 [95% CI 1.3-3.4], P=.003), gestational age at PPROM (P=.025), prolonged rupture of membranes (P<.0001), administration of tocolytic agents (1.8 [1.1-3.0], P=.019) and antibiotics (1.9 [1.2-3.1], P=.008) were associated with PVL. The use of tocolytic agents >24 h (P=.008), prolonged latency between the increase in maternal leukocyte count and birth (P=.034), spontaneous onset of labor (1.8 [1.0-2.9], P=.026), vaginal delivery (1.7 [1.1-2.8], P=.029) and male gender (1.5 [1.0-2.0], P=.04) were found more frequently in PVL cases. Preeclampsia (0.4 [0.1-0.9], P=.034), hypertension at booking (P=.009), sonographic IUGR (P=.020), abnormal blood flow of the umbilical artery (P=.032) and cesarean section without labor (0.5 [0.3-0.8], P=.006) were found less frequently. In logistic regression analysis, prolonged rupture of the membranes (P=.748), preeclampsia (P=.973), the use of antibiotics (P=.617) and beta-sympathomimetic tocolytic agents (P=.563) lost statistical significance, whereas birth weight (P=.036) became significant. CONCLUSION:PPROM and prolonged rupture of the membranes may provoke adverse effects on the neurodevelopmental outcome of the preterm fetus. These findings may have implications on the obstetric management of PPROM beyond 30 weeks of gestation. Cesarean section without labor was less likely associated with the diagnosis of PVL.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Bauer M,Fast C,Haas J,Resch B,Lang U,Pertl Bdoi
10.1016/j.earlhumdev.2008.07.007subject
Has Abstractpub_date
2009-03-01 00:00:00pages
163-9issue
3eissn
0378-3782issn
1872-6232pii
S0378-3782(08)00130-8journal_volume
85pub_type
杂志文章abstract：INTRODUCTION:The sex ratio at birth (usually denoted as M/T=male divided by total births) is influenced by cultural factors. The Chinese Zodiac holds that women born in the Fire Horse year (1966) would be unlucky. It has been shown that significantly less children were born in Japan in this year. This study was carried...
journal_title：Early human development
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
abstract：:The essential fatty acid (EFA) composition of umbilical vessel walls is increasingly being studied as a longer-term reflection of the fetal EFA status. We evaluated the EFA content of umbilical artery and vein vessel walls in 43 preterm infants and compared it with that of 43 full-term cord vessels. In addition, relat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01656-n
更新日期：1995-08-18 00:00:00
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journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.10.011
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis....
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.09.010
更新日期：2006-04-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90036-6
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:The importance of an infant's intra-oral vacuum in milk removal from the breast has been established. However, the relationship between the vacuum curve and milk transfer is not well understood. AIMS:To investigate the parameters of the infant suck cycle in relation to the volume of milk removed from the br...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.02.003
更新日期：2016-05-01 00:00:00
abstract：:Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90178-w
更新日期：1993-10-01 00:00:00
abstract：:The reactions of heart rate (HR), systolic (sBP) and diastolic (dBP) blood pressure were studied in response to passive head-up tilting (successively to +45 degrees and +90 degrees) in a group of 83 full-term, 1- to 7-day-old newborns who were quiet and awake. A significant mean increase of HR was noted for the whole ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01706-2
更新日期：1996-03-22 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.05.017
更新日期：2010-07-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.01.009
更新日期：2013-04-01 00:00:00
abstract：AIMS:1. To determine the survival and morbidity of infants at discharge with a birthweight of less than 1500 g in the geographically defined population of East Anglia. 2. To demonstrate a cost-effective method of regional data collection. 3. To determine whether there were any changes in the demand for neonatal care. ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.10.019
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Preterm infants have immature skin, which contributes to skin problems. Very little is known about postnatal changes in the skin, despite the clinical importance of this issue. AIM:To assess temporal changes in skin water content in preterm infants. STUDY DESIGN:A prospective observational study. SUBJECTS...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.05.009
更新日期：2015-09-01 00:00:00
abstract：:Behavioural state observations were carried out on 12 fetuses which subsequently had birthweights below the 10th percentile. Their gestational ages at the time of study ranged from 32 to 40 weeks. Real-time ultrasound scanning was used to detect fetal body and eye movements, and the fetal heart rate was continuously r...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90181-1
更新日期：1985-11-01 00:00:00
abstract：:Given the widely acknowledged inverse relationship between birth weight and blood pressure, a raised blood pressure in the offspring of smoking mothers as compared to those whose mothers did not smoke, would be anticipated by virtue of the reduction in birth weight associated with smoking during pregnancy. The objecti...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00064-x
更新日期：2000-02-01 00:00:00
abstract：:28 polygraphic recordings were made in normal infants: 20 in full-term newborns and 8 in 2- to 10-wk-old babies. In full-term newborns sighs and apneas (greater than 5 sec) were significantly more numerous in active (REM) sleep, while startles prevailed in quiet (NREM) sleep. The incidence of all these events diminish...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(78)90051-8
更新日期：1978-04-01 00:00:00
abstract：OBJECTIVE:To assess patterns of nutritive sucking in very preterm infants ≤32 weeks of gestation. STUDY DESIGN:Very preterm infants who attained independent oral feeding were prospectively assessed with an instrumented feeding bottle that measures nutritive sucking. The primary outcome measure was nutritive sucking pe...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105044
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Previously, we reported that regular maternal aerobic exercise during pregnancy was associated with lower fetal heart rate (HR) and higher heart rate variability (HRV) at 36weeks gestation. We now report the effect of maternal exercise on infant HR and HRV in subjects who remained active in the study at the ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.11.001
更新日期：2014-01-01 00:00:00
abstract：:The early progress of myelination was studied, by means of myelin basic protein (MBP) immunohistochemistry and luxol-fast-blue (LFB) staining, in the spinal cord, spinal nerve roots and brainstem of 66 fetuses and neonates. The degree of myelination was classified from 1 (slight) to 4 (mature). MBP immunoreactivity ex...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)01608-r
更新日期：1995-03-17 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90121-5
更新日期：1985-05-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.06.002
更新日期：2012-10-01 00:00:00
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journal_title：Early human development
pub_type： 评论,信件
doi：10.1016/j.earlhumdev.2010.09.372
更新日期：2011-01-01 00:00:00
abstract：:The magnitude of inflating pressure necessary for effective resuscitation was examined in 70 preterm infants. The median pressure to cause adequate chest wall expansion was 22.8 cmH2O; no infant required a peak inflating pressure greater than 30 cmH2O. No further increase in inflation pressure was used during resuscit...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90045-5
更新日期：1991-07-01 00:00:00
abstract：:White matter injury and abnormal maturation are thought to be major contributors to the neurodevelopmental disabilities observed in children and adolescents who were born preterm. Early detection of abnormal white matter maturation is important in the design of preventive, protective, and rehabilitative strategies for...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2008.09.004
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Preterm children are at risk for executive function (EF) problems, which have been linked to behavior and learning problems in full term children. In this study, we examine the relationship between EF and functional outcomes in preterm children. AIM:To evaluate (1) EF skills of 9- to 16-year-old children bo...
journal_title：Early human development
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2012-02-01 00:00:00
abstract：:Twenty-four term infants with disproportionate intrauterine growth retardation (SGA group) and 24 normally grown term infants matched for age, sex, birth rank and social class were followed from birth until 7 years of age. Both groups were free from perinatal complications and chronic diseases. The children in the SGA...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(88)90038-2
更新日期：1988-11-01 00:00:00
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journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105221
更新日期：2020-12-01 00:00:00
abstract：:There is increasing evidence that sleep plays a major role in the development of neural pathways in the neonatal brain. Several studies have suggested evidence-based approaches to improve sleep for infants admitted to the neonatal intensive care unit (NICU); however, in many neonatal centers very few of these strategi...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:In the face of evidence of human milk contamination by organochlorine pesticides, an analysis was performed on samples of milk obtained from healthy lactating women in the provinces of Granada and Almeria in Southern Spain. The samples were obtained by the Neonate Section of the Department of Pediatrics of Granada Uni...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(01)00221-3
更新日期：2001-11-01 00:00:00
abstract：:In a prospective clinical study from an unselected, area-based population, the influence on birthweight for gestational age of different factors was studied, with special respect to 15 risk factors for intrauterine growth retardation (IUGR) recognizable in early pregnancy. In the multiple regression analyses performed...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90110-5
更新日期：1984-09-01 00:00:00
