Abstract：
BACKGROUND:Among preterm infants, high concentrations of inflammatory mediators in cerebrospinal fluid (CSF) are associated with poor outcome. Previous studies have not indicated whether CSF concentrations of inflammatory mediators are associated with important confounders such as gestational age. AIMS:To examine associations between CSF concentrations of inflammatory mediators and gestational age, maternal features suggestive of inflammation, characteristics of the CSF sample or the presence of a systemic inflammatory response. STUDY DESIGN AND SUBJECTS:Aliquots of CSF obtained during routine investigation of potential sepsis among infants born before 35 weeks gestation were assayed for 17 mediators of inflammation using a fluorescent multi-bead analyser. Other information was collected from routine clinical records. RESULTS:39 infants were assessed. CSF levels of mediators of inflammation were not correlated with gestational age. CSF red blood cell counts were correlated with CSF concentrations of IL-6, GM-CSF and IL-17 (each p<0.003). CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta. CSF concentrations of IL-1beta, IL-6, G-CSF, TNF-alpha and IFN-gamma were higher in infants with a raised CRP within 24 h of delivery (each p<0.003). CONCLUSIONS:CSF concentrations of inflammatory mediators most probably reflect inflammatory pathologies and are not influenced by gestational age. They may also, however, reflect contamination with blood or systemic inflammation. CSF concentrations of inflammatory mediators may not provide a specific indicator of CNS inflammation.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Turner MA,Drury JA,Carlin A,O'Neill S,Pilling D,Barnes N,Balmer P,Newland P,Clark S,Kissack CM,Subhedar NVdoi
10.1016/j.earlhumdev.2008.10.011subject
Has Abstractpub_date
2009-04-01 00:00:00pages
259-62issue
4eissn
0378-3782issn
1872-6232pii
S0378-3782(08)00620-8journal_volume
85pub_type
杂志文章abstract：:Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-1 (IGFBP-1) were measured in amniotic fluid, extraembryonic coelomic fluid and maternal serum from 23 women with apparently normal first trimester pregnancies prior to termination. The levels of IGF-1 and IGFBP-1 were significantly hig...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90105-p
更新日期：1992-02-01 00:00:00
abstract：:The Golgi-Cox method was used to study the maturation of the large pyramidal cells of the Vth cortical layer in three groups of adult rats: one subjected to undernutrition during the first month of life, another throughout the first 2 mth of life, and the last one during gestation and the suckling period. The main alt...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90186-6
更新日期：1986-12-01 00:00:00
abstract：:The worst of institutional care was brought to public attention in Romania during the 1990s when pictures of severely deprived and malnourished children were shown around the world. However, many European countries have high rates of young children in institutions, where the physical care of the child predominates, wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.09.018
更新日期：2012-12-01 00:00:00
abstract：:Ninety five placentae from normal term and 'normal' preterm pregnancies have been analysed by morphometry. The growth of the whole placenta, of the microscopic placental constituents and of the villous surface area has been measured in placentae from uncomplicated pregnancies from 10 weeks of gestation to term to prov...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(84)90074-4
更新日期：1984-06-01 00:00:00
abstract：:We measured plasma and erythrocyte vitamin E (VE) and plasma vitamin A (VA) profiles in 48 full-term and 8 preterm pairs of neonates and their mothers at birth and we determined whether there is any relationship between maternal and umbilical cord for the nutrients measured. At the same time, we assessed the influence...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00070-x
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.08.017
更新日期：2003-12-01 00:00:00
abstract：:To precisely measure the events of the fetal breath cycle it is necessary to have an accurate hard copy record. Two approaches to this have been made using either M-mode or Doppler ultrasound. It was the aim of this paper to compare these methods. Hard copy records of fetal breathing movements were produced by simulta...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90010-8
更新日期：1989-12-01 00:00:00
abstract：:The aim is to know whether antenatal olfactory learning have a greater effect than postnatal olfactory learning on infant feeding even in the absence of triggering signals. We evaluated the sucking behavior of infants completely separated from their mothers for 10-14 days since birth. The 12 infants admitted to Chiba ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.10.003
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Somatosensory evoked potentials (SEPs) offer an additional bedside tool for outcome prediction after perinatal asphyxia. AIMS:To assess the reliability of SEPs recorded with bifrontoparietal amplitude-integrated electroencephalography (aEEG) brain monitoring setup for outcome prediction in asphyxiated newbo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105287
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Preterm infants have immature skin, which contributes to skin problems. Very little is known about postnatal changes in the skin, despite the clinical importance of this issue. AIM:To assess temporal changes in skin water content in preterm infants. STUDY DESIGN:A prospective observational study. SUBJECTS...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.05.009
更新日期：2015-09-01 00:00:00
abstract：:Relationships between maternal factors associated with very slow and very fast fetal growth rate, and the postnatal growth patterns within groups of 238 small-for-dates (SFD) and 241 large-for-dates (LFD) children were examined. Within the SFD group significant differences were found in their weight, height, and to a ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90036-6
更新日期：1982-12-01 00:00:00
abstract：:Low nephron endowment secondary to intrauterine growth restriction (IUGR) results in compensatory hypertrophy of the remaining glomeruli, which in turn is associated with hypertension. However, gender differences exist in the response of the kidney to injury, and IUGR female offspring seems protected from an unfavorab...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.12.015
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Preterm birth is a known risk factor for infant development but it is less clear whether fetal growth restriction (FGR) and early term birth between 37 and 39 weeks gestation are associated with risks for infant development. AIMS:This study investigated risk factors for adverse developmental outcomes at 12 ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.104951
更新日期：2020-03-01 00:00:00
abstract：:Maturation of spontaneous fetal body and breathing movements of 24- to 33-week-old fetuses in 168 pregnancies threatening to deliver prematurely were examined on the basis of newborn outcome (premature compromised, premature healthy, term healthy). Maturation of fetuses in 60 low-risk pregnancies delivering as healthy...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00007-9
更新日期：1999-05-01 00:00:00
abstract：:Atrial natriuretic factor (ANF) has been well known as a potent natriuretic peptide. The purpose of this study was to clarify the physiological role of ANF in neonates. We designed two types of study to investigate the role of ANF in neonates. (i) The role of ANF in neonatal fluid homeostasis; (ii) ANF and spontaneous...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90132-z
更新日期：1992-06-01 00:00:00
abstract：INTRODUCTION:In neonates with spina bifida aperta (SBA), leg movements by myotomes caudal to the meningomyelocele (MMC) are transiently observed. It is unclear whether these leg movements relate to functional neural conduction through the MMC. For optimal therapeutical intervention, pathophysiological insight in these ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.09.002
更新日期：2006-04-01 00:00:00
abstract：:In planning enteral feeding in the preterm infant, decisions need to be made regarding the feeding schedule, choice of milk, and the route of administration. Feeds should be commenced within a week after birth beginning with subnutritional quantities. Preterm human milk from the infant's own mother is the milk of choi...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/s0378-3782(99)00047-x
更新日期：1999-12-01 00:00:00
abstract：:The relationship between the traction forces used in 53 clinically indicated vacuum extractions and the incidence and degree of retinal hemorrhages observed in the neonates within 24 hours after birth was examined. A Vacuum Extractor Recorder (Type SF 30, Knick), was used to measure the traction force necessary for de...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(88)90107-7
更新日期：1988-03-01 00:00:00
abstract：:Fifty-five pregnant Rhesus isoimmunized women were subjected to fetal blood sampling or fetal blood transfusion on 135 occasions. Glucose and C-peptide concentrations were measured in fetal blood, in addition to the routine investigations for complete blood count, blood gases and lactate concentration, in order to inv...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90027-g
更新日期：1990-12-01 00:00:00
abstract：:Studies in encephalopathic infants have demonstrated a brief phase of normal cerebral energetics following hypoxia-ischaemia prior to development of delayed energy failure. In experimental models, mild hypothermia has shown a consistent neuroprotective action, although its efficacy is critically dependent on the sever...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2004.10.014
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Higher parenting stress in mothers of children born very preterm may be in part a response to poorer neurobehavioral development, reflecting realistic concerns in addition to adaptation to the trauma of preterm delivery. To our knowledge, there are few longitudinal studies of parenting stress that have addre...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2011.01.030
更新日期：2011-04-01 00:00:00
abstract：:Near infrared spectroscopy (NIRS) monitoring is a new challenge for clinicians who deal with early detection of dangerous hypoperfusion in the brain, as well as in splanchnic and renal districts in critically ill preterm infants. Previous studies performed on infants and children with congenital heart disease, demonst...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(13)70014-8
更新日期：2013-06-01 00:00:00
abstract：AIM:This study examined the rates of follow-up for a cohort of extremely preterm (EP -<28weeks gestation) and/or extremely low birthweight (ELBW -<1000g) children at two years with related perinatal and geographical factors. The secondary aim was to determine the rates of developmental delay and disability. METHODS:A ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.09.012
更新日期：2015-12-01 00:00:00
abstract：:Vascular tumours (haemangiomas and malformations) are common tumours of infancy and childhood. They represent a group of mostly benign conditions, which present early, can grow rapidly and be symptomatic or disfiguring. There are various management options, with different cosmetic and functional outcomes. Haemangiomas...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.08.017
更新日期：2010-10-01 00:00:00
abstract：AIM:To assess whether attrition rate influences outcome in the follow-up of very preterm infants. STUDY DESIGN:In a national follow-up study of infants born alive in 1983 in the Netherlands with a gestational age less than 32 weeks and/or a birth weight less than 1500 g, outcome was assessed separately for adolescents...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2005.07.006
更新日期：2005-11-01 00:00:00
abstract：:We have investigated 20 healthy full-term newborns between the 4th and the 6th day of life in standard conditions for laterality of arm movements, before and after introduction of a target. The durations of recording were: (a) 5 min continuously before target introduction; (b) five 1-min units during target presentati...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90099-6
更新日期：1989-04-01 00:00:00
abstract：:Cranial ultrasound is the most available and easily repeatable technique for imaging the neonatal brain. Its quality and diagnostic accuracy depend on various factors; the suitability of the ultrasound machine for neonatal cranial work, the use of optimal settings and probes, appropriate scanning protocols, the use of...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2006.09.018
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Although highly beneficial, human milk feeding is challenging in preterm infants due to adverse NICU factors for the infant and mother. AIM:To investigate the effects of an early intervention in promoting infant's human milk feeding and acquisition of full oral feeding. METHODS:This study is part of a RCT....
journal_title：Early human development
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.earlhumdev.2018.04.016
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To assess patterns of nutritive sucking in very preterm infants ≤32 weeks of gestation. STUDY DESIGN:Very preterm infants who attained independent oral feeding were prospectively assessed with an instrumented feeding bottle that measures nutritive sucking. The primary outcome measure was nutritive sucking pe...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2020.105044
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:An increased risk of major congenital abnormalities after IVF and ICSI has been described, but underlying mechanisms are unclear. This study evaluates the effects of ovarian hyperstimulation, the in vitro procedure and time to pregnancy (TTP) - as proxy for the severity of subfertility - on the prevalence of...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.06.002
更新日期：2012-10-01 00:00:00
