Abstract:
INTRODUCTION:In neonates with spina bifida aperta (SBA), leg movements by myotomes caudal to the meningomyelocele (MMC) are transiently observed. It is unclear whether these leg movements relate to functional neural conduction through the MMC. For optimal therapeutical intervention, pathophysiological insight in these transient leg movements seems relevant. If leg movements by myotomes caudal to the MMC concur with the execution of general movements (GMs), functional neural conduction through the MMC is implicated. OBJECTIVE:In neonates with SBA, we aimed to determine whether the transiently present leg movements caudal to the MMC indicate functional neural conduction through the MMC. METHODS:During the perinatal period, fetuses and neonates with SBA (n = 7 and n = 13, respectively) were longitudinally analysed for concurrency between leg movements caudal to the MMC and GMs. To address the integrity of the reflex arc in spinal segments (at, or) caudal to the MMC, tendon leg reflexes were assessed during the first postnatal week. RESULTS:At postnatal day 1, leg movements caudal to the MMC concurred with GMs in 12 of 13 infants. Isolated leg movements were observed in only 3 of these 12 infants (isolated vs. concurrent; p < 0.005). Leg movements concurring with GMs lasted longer than isolated leg movements (median duration = 11 s vs. 2 s; p < 0.05). Between days 1 and 7, tendon leg reflexes (at, or) caudal to the MMC had disappeared in all but 1 neonate. However, leg movements caudal to the MMC remained concurrently present with GMs in all five neonates available for follow-up after day 7. Comparing these leg movements between days 1 and 7 indicated a decreased duration (-44%, p < 0.05). CONCLUSIONS:In neonates with SBA, leg movements caudal to the MMC concur with GMs, indicative of functional neural conduction through the MMC. The disappearance of these leg movements is caused by lower motor neuron dysfunction at the reflex arc, whereas neural conduction through the MMC is still functional.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Sival DA,Brouwer OF,Bruggink JL,Vles JS,Staal-Schreinemachers AL,Sollie KM,Sauer PJ,Bos AFdoi
10.1016/j.earlhumdev.2005.09.002keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
227-34issue
4eissn
0378-3782issn
1872-6232pii
S0378-3782(05)00185-4journal_volume
82pub_type
杂志文章abstract:BACKGROUND:An increased risk of major congenital abnormalities after IVF and ICSI has been described, but underlying mechanisms are unclear. This study evaluates the effects of ovarian hyperstimulation, the in vitro procedure and time to pregnancy (TTP) - as proxy for the severity of subfertility - on the prevalence of...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.06.002
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To determine whether early mortality (first year of life) risks among small for gestational age (SGA) neonates were similar regardless of SGA subtype based on three chronological classifications (term, preterm and post-term). STUDY DESIGN:Retrospective cohort study on all singleton live births in the United...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.05.008
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Among preterm infants, high concentrations of inflammatory mediators in cerebrospinal fluid (CSF) are associated with poor outcome. Previous studies have not indicated whether CSF concentrations of inflammatory mediators are associated with important confounders such as gestational age. AIMS:To examine asso...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.10.011
更新日期:2009-04-01 00:00:00
abstract::Developmental changes in muscle coordination patterns of normal and abnormal general movements (GMs) are described. GMs were studied simultaneously with video-recording and polymyography (polyEMG). GMs of normal full-term infants gradually lose their neonatally slow and 'writhing' character, to be turned into the eleg...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(93)90038-v
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Higher parenting stress in mothers of children born very preterm may be in part a response to poorer neurobehavioral development, reflecting realistic concerns in addition to adaptation to the trauma of preterm delivery. To our knowledge, there are few longitudinal studies of parenting stress that have addre...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.01.030
更新日期:2011-04-01 00:00:00
abstract::Studies in encephalopathic infants have demonstrated a brief phase of normal cerebral energetics following hypoxia-ischaemia prior to development of delayed energy failure. In experimental models, mild hypothermia has shown a consistent neuroprotective action, although its efficacy is critically dependent on the sever...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2004.10.014
更新日期:2005-01-01 00:00:00
abstract::Pancreatic protease deficiency may be an aetiological factor in enteritis necroticans, a disease sharing some features of necrotising enterocolitis (NEC). Using faecal chymotrypsin measurement we have prospectively studied pancreatic exocrine function in infants at risk of NEC. No significant difference was found comp...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(93)90100-9
更新日期:1993-12-15 00:00:00
abstract::Nurses worldwide have striven to establish nursing as a profession, autonomous but complementary to the medical profession. Literature as far back as the Renaissance demonstrates an overall derogatory attitude toward the nurse's role. The modern notion of the nurse working side by side the medical practitioner continu...
journal_title:Early human development
pub_type: 杂志文章,实务指引
doi:10.1016/j.earlhumdev.2020.105015
更新日期:2020-06-01 00:00:00
abstract::Delayed emergence of movement patterns and disturbances in the development of behavioural states are often observed in the fetuses of diabetic women. The developmental course of specific fetal movement patterns was studied in 20 women with type-1 diabetes during the first trimester of pregnancy. The aim was to investi...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90190-e
更新日期:1991-05-01 00:00:00
abstract:INTRODUCTION:Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV-pulmonary vasculature (PV) coupling. RV-PV can be assessed with the RV length-force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration ti...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2018.11.006
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Little is known about sex differences in human fetal heart and behaviour. PATIENTS AND METHODS:One hundred twenty-three nulliparous healthy women carrying a male (n=56) or female (n=67) fetus participated in this study. All pregnancies remained uncomplicated and delivery was uneventful. Ultrasound observa...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(03)00047-1
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Preterm birth is a known risk factor for infant development but it is less clear whether fetal growth restriction (FGR) and early term birth between 37 and 39 weeks gestation are associated with risks for infant development. AIMS:This study investigated risk factors for adverse developmental outcomes at 12 ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.104951
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND AIM:Swaddling is a well-known technique in developmental care programs as there is some evidence that swaddling is an appropriate stress-reducing method for preterm infants in the NICU. However, no experimental study has investigated the influence of swaddling in a learning context. This study aimed to a...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105288
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Movement by an infant during the first year of life might influence its activity level and thereby influence growth in early childhood. AIM:To examine whether the time that an infant is able to move unrestrictedly and time spent in baby seats are related to weight and waist circumference at age 9 months and...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.04.002
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The entorhinal cortex serves as an important gateway between the cerebral cortex and the hippocampus by receiving afferent information from limbic, modality sensory-specific, and multimodal association fibers from all the brain lobes. AIM:To investigate whether thinning of entorhinal cortex is associated wi...
journal_title:Early human development
pub_type: 临床试验,杂志文章
doi:10.1016/j.earlhumdev.2011.07.017
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Antenatal depression is associated with adverse social-emotional and behavioural outcomes during childhood but there has been little investigation of the impact on infant neurodevelopment during the first postnatal year. AIMS:The aim of this study was to assess the impact of depression during pregnancy on i...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.05.021
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To assess whether patterns of growth trajectory during infancy are associated with intelligence quotient (IQ) scores at 4 years of age in children born small-for-gestational age (SGA). METHODS:Children in the Collaborative Perinatal Project born SGA were eligible for analysis. The primary outcome was the Sta...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.06.002
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:COVID-19 is pandemic. International travel bans in March 2020 dampened viral spread and resulted in an overnight global economic crisis. As countries ease travel and social distancing restrictions, viral resurgences are expected. This study was carried out in order to delineate the development of a second ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105211
更新日期:2020-10-03 00:00:00
abstract::Pulse oximetry screening for critical congenital heart defects (CCHDs) is a highly specific, moderately sensitive test which is cost effective, acceptable to both clinical staff and parents and meets the criteria for universal screening. Pulse oximetry screening is gaining considerable worldwide support and last year ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.09.013
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the preschool neurodevelopmental outcome in CDH survivors between 2 and 5 years of age and to identify perinatal and postnatal factors that may be predictive of persistent neurological deficits. METHODS:The study cohort consists of 60 CDH survivors that were enrolled in our prospective, follow-up...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.12.009
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:There is concern that exposure of preterm infants to noxious insults over a prolonged period may have long term effects on their developing nervous system. AIMS:To investigate medium and long term effects of heel pricks in infants over the first year of life. STUDY DESIGN:Study 1-a longitudinal study, 2 da...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2007.09.018
更新日期:2008-06-01 00:00:00
abstract::Intra-uterine growth restriction (IUGR) is a severe and quite common problem in obstetrics. A condition of placental dysfunction can lead to a cardiovascular adaptation in the fetus characterized by a redistribution of cardiac output to maintain oxygen supply to the heart, adrenal glands and brain - the so-called brai...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.07.006
更新日期:2013-10-01 00:00:00
abstract::A comparison has been made of protein accretion and growth in premature infants fed banked drip breast milk (BBM) or a preterm formula (PF). Protein accretion was calculated from the difference between dietary nitrogen intake and output in urine and stools, measured in a nutrient balance study. As expected, only the i...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90152-5
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.06.006
更新日期:2011-12-01 00:00:00
abstract::Urinary epidermal growth factor (EGF) excretion was studied serially in 36 newborn infants, from 26 to 40 weeks gestation, from birth to three months of age. All infants excreted EGF from birth. Excretion was significantly higher in term infants than in preterm infants at birth; in term infants excretion rose steadily...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(86)90190-8
更新日期:1986-12-01 00:00:00
abstract:AIMS:Mastitis in lactating mothers reduces milk production and alters the cellular composition of milk. Changes occurring in the mammary gland during the inflammatory response are believed to increase the permeability of the blood-milk barrier. This study examined the effect of mastitis during lactation on the macronut...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.03.009
更新日期:2016-07-01 00:00:00
abstract::The magnitude of inflating pressure necessary for effective resuscitation was examined in 70 preterm infants. The median pressure to cause adequate chest wall expansion was 22.8 cmH2O; no infant required a peak inflating pressure greater than 30 cmH2O. No further increase in inflation pressure was used during resuscit...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(91)90045-5
更新日期:1991-07-01 00:00:00
abstract::The purpose of this study was to compare two different methods for assessing fetal heart rate (FHR)--fetal eye movement (FEM) synchronization: (1) periods of high (HV) and low (LV) variability in the FHR and the presence (EM) and absence (NEM) of FEM were determined by visual inspection and the degree of association b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90137-6
更新日期:1992-09-01 00:00:00
abstract::Neonatal hyperglycaemia is a frequent complication in VLBW infants during the first week of life. The more common causes include high glucose intake, stress situations such as sepsis, NEC, and surgical treatments, as well as the administration of vasoactive drugs and methylxanthines. The appropriate definition is uncl...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2011.01.005
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Maternal smoking during pregnancy is associated with short-term and also long-term harmful effects on offspring. OBJECTIVE:The aim of this study is to evaluate the associations of maternal smoking during pregnancy with offspring bone health at 18years old, and the role of birth weight and contemporaneous he...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.08.024
更新日期:2014-12-01 00:00:00