Maternal RhD heterozygous genotype is associated with male biased secondary sex ratio.

Abstract:

BACKGROUND:Previous studies suggest that RhD positive heterozygotes express better health status than RhD positive homozygotes and especially RhD negative subjects. This also applies to pregnant women. According to the Trivers-Willard hypothesis, women in better physical condition should have more sons. AIM:To test the hypothesis that RhD positive heterozygous mothers have a male-skewed sex ratio. STUDY DESIGN:Cross-sectional study. The data was analysed using Chi-Square test for all women, separately for RhD positive and RhD negative women, and separately for primiparous and multiparous women. The effects of maternal weight as a continuous predictor and the RhD phenotype of newborn as a categorical predictor of newborn sex were evaluated by the generalized linear model (GLZ) separately for RhD positive and RhD negative women using binomial distribution and logit link function. OUTCOME MEASURES:Clinical records comprised maternal weight before pregnancy, number of previous deliveries, sex of the newborn, maternal RhD phenotype, and RhD phenotype of the newborn. SUBJECTS:We analysed data from 5655 women who gave birth between 2008 and 2012 in General University Hospital in Prague. RESULTS:Secondary sex ratio was significantly higher (P = 0.028) in RhD positive mothers who had RhD negative newborns, i.e., in heterozygotes (SR = 1.23), than in RhD positive mothers who had RhD positive newborns, i.e., in a mixed population of heterozygotes and homozygotes (SR = 1.00), especially in primiparous women (P = 0.013; SR = 1.37 and 0.99 resp.). CONCLUSION:The sex ratio at birth was significantly higher in RhD positive mothers who had RhD negative newborns than in RhD positive mothers who had RhD positive newborns.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Kaňková Š,Flegr J,Toman J,Calda P

doi

10.1016/j.earlhumdev.2019.104864

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

104864

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(19)30518-3

journal_volume

140

pub_type

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