The effect of low-dose erythromycin on whole gastrointestinal transit time of preterm infants.

Abstract:

UNLABELLED:The aim of the study was to determine the effect of a low oral dose of erythromycin on whole gastrointestinal transit time [WGTT]. Erythromycin [EM] [1.5 mg/kg, 6 hourly] or placebo was given first over 7 days in a double blind randomized crossover study of 21 preterm infants with feed intolerance. Median [range] birth weight was 1420 [690, 2200] g and postconceptual age 32. 5 [20, 36.4] weeks. WGTT was assessed on day 3 of each treatment, by timing the transit of carmine red through the gut. Treatments were compared using Student's paired t test. RESULTS:WGTT was significantly shorter following EM treatment as compared to placebo: mean [SD] 10.16 [4.6] h vs. 15. 9 [7.2] h, p<0.01. CONCLUSION:Oral low-dose EM significantly shortens WGTT of feed-intolerant preterm infants.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Costalos C,Gavrili V,Skouteri V,Gounaris A

doi

10.1016/s0378-3782(01)00191-8

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

91-6

issue

2

eissn

0378-3782

issn

1872-6232

pii

S0378378201001918

journal_volume

65

pub_type

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