Corticotropin-releasing hormone peptide and human first-trimester placental growth.

Abstract:

:The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblastic cells in proliferative cell columns and in chorionic villi. We postulate that CRH may have an important role in early placental development and successful pregnancy.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Choy MY,Leung TN,Lau TK

doi

10.1016/j.earlhumdev.2004.04.010

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

77-80

issue

1

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(04)00053-2

journal_volume

79

pub_type

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