Corticotropin-releasing hormone peptide and human first-trimester placental growth.


:The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblastic cells in proliferative cell columns and in chorionic villi. We postulate that CRH may have an important role in early placental development and successful pregnancy.


Early Hum Dev


Early human development


Choy MY,Leung TN,Lau TK





Has Abstract


2004-08-01 00:00:00














  • Load perturbation does not influence spontaneous movements in 3-month-old infants.

    abstract:BACKGROUND:The assessment of the quality of general movements (GMs) in young infants is a reliable and valid diagnostic tool for detecting brain dysfunction early in life. Of special interest is a type of GMs called fidgety movements (FMs) characteristic for 3- to 5-month-old infants. GMs are part of an infant's sponta...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Dibiasi J,Einspieler C

    更新日期:2004-04-01 00:00:00

  • Peer support and interpersonal psychotherapy groups experienced decreased prenatal depression, anxiety and cortisol.

    abstract::Forty-four prenatally depressed women were randomly assigned to peer support or interpersonal psychotherapy groups at 22 weeks gestation. The peer support group participated in a 20-minute group session once per week for 12 weeks, and the interpersonal psychotherapy group met for one hour per week for 12 weeks. Assess...

    journal_title:Early human development

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Field T,Diego M,Delgado J,Medina L

    更新日期:2013-09-01 00:00:00

  • Sirenomelia in a twelve weeks abortus.

    abstract::The anatomical findings of sirenomelia in a 12-weeks aborted embryo are reported. The occurrence of sirenomelia in material from spontaneous abortions is discussed. ...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Malinger G,Treschan O,Rosen N,Zakut H

    更新日期:1987-07-01 00:00:00

  • The premature infant's respiratory response to mechanical ventilation.

    abstract::Comparisons of the components of ventilator waveform were made in two groups of preterm infants ventilated for the respiratory distress syndrome. Infants actively expiring against positive pressure inflation were compared to infants not showing this interaction. The actively expiring infants were ventilated with a hig...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Greenough A

    更新日期:1988-05-01 00:00:00

  • Progress of myelination in the human fetal spinal nerve roots, spinal cord and brainstem with myelin basic protein immunohistochemistry.

    abstract::The early progress of myelination was studied, by means of myelin basic protein (MBP) immunohistochemistry and luxol-fast-blue (LFB) staining, in the spinal cord, spinal nerve roots and brainstem of 66 fetuses and neonates. The degree of myelination was classified from 1 (slight) to 4 (mature). MBP immunoreactivity ex...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Tanaka S,Mito T,Takashima S

    更新日期:1995-03-17 00:00:00

  • The changing face of haemolytic disease of the newborn.

    abstract::The diagnosis, acute management and follow-up of neonates with haemolytic disease of the newborn (HDN) still represents a significant area of activity for maternity/neonatal services. ABO incompatability is now the single largest cause of HDN in the western world. However, with increasing knowledge at the molecular le...

    journal_title:Early human development

    pub_type: 杂志文章,实务指引,评审


    authors: Roberts IA

    更新日期:2008-08-01 00:00:00

  • Retinol-binding protein and prealbumin in cord blood of term and preterm infants.

    abstract::Retinol-binding protein (RBP) and prealbumin (PA) are potentially useful indicators of inadequate protein and/or energy intake. Concentrations of RBP and PA were determined in cord blood of 117 infants and were found to be lower before 37 weeks gestation than at term. Adult subjects had substantially higher concentrat...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Bhatia J,Ziegler EE

    更新日期:1983-07-01 00:00:00

  • Prenatal maternal stress: effects on pregnancy and the (unborn) child.

    abstract:BACKGROUND:Animal experiments have convincingly demonstrated that prenatal maternal stress affects pregnancy outcome and results in early programming of brain functions with permanent changes in neuroendocrine regulation and behaviour in offspring. AIM:To evaluate the existing evidence of comparable effects of prenata...

    journal_title:Early human development

    pub_type: 杂志文章,评审


    authors: Mulder EJ,Robles de Medina PG,Huizink AC,Van den Bergh BR,Buitelaar JK,Visser GH

    更新日期:2002-12-01 00:00:00

  • Fetal superior mesenteric artery: longitudinal reference ranges and evidence of regulatory link to portal liver circulation.

    abstract:OBJECTIVE:To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PI(SMA)). Also to examine the hemodynamic relationship to venous liver perfusion and umbilical flow distribution in the liver, to other splanchnic arteries, and more generally to the ...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Ebbing C,Rasmussen S,Godfrey KM,Hanson MA,Kiserud T

    更新日期:2009-04-01 00:00:00

  • Echocardiography predicts closure of patent ductus arteriosus in response to ibuprofen in infants less than 28 week gestational age.

    abstract:BACKGROUND:Patent ductus arteriosus (PDA) is a frequent problem in preterm infants, and its incidence is inversely correlated with gestational age. The efficacy of medical treatment decreases with decreasing gestational age (GA), and failure rates as well as ductus ligation rates of 40% have been reported in <28 week G...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Pees C,Walch E,Obladen M,Koehne P

    更新日期:2010-08-01 00:00:00

  • The effect of perinatal factors on cord thyroxine concentration.

    abstract::Cord blood thyroxine (T4) concentrations were measured in 4,068 infants from 28 wk gestation to term. Each chart was reviewed for the following factors: delivery by cesarean section, prolonged rupture of membranes, neonatal asphyxia, meconium-stained amniotic fluid, maternal diabetes mellitus and twinning. Each neonat...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Erenberg A

    更新日期:1978-09-01 00:00:00

  • Creamatocrit, carbon content, and energy value of pooled banked human milk: implications for feeding preterm infants.

    abstract::It is convenient to calculate milk energy from the creamatocrit but in order to assess the accuracy with which energy content can be predicted in this way, the creamatocrit, the percentage of carbon, and the calorie value of milk were determined in 11 samples of pooled pasteurised human milk. The calculated milk energ...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Smith L,Bickerton J,Pilcher G,D'Souza SW

    更新日期:1985-05-01 00:00:00

  • Excretion of cyclic 3',5'-adenosine monophosphate in the early newborn period.

    abstract::The relationship between cyclic 3',5'-adenosine monophosphate (cAMP) excretion and creatinine clearance, urinary phosphate excretion, and urinary osmolarity was studied under basal conditions in 29 babies of 28-40 weeks gestation, during the first few days of life. Urinary cAMP excretion was directly related to creati...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Siegel SR

    更新日期:1984-09-01 00:00:00

  • Neonatal hyperbilirubinemia and kernicterus - not gone but sometimes forgotten.

    abstract::The introduction of exchange transfusion made it possible to prevent severe hyperbilirubinemia and kernicterus, but kernicterus has never completely disappeared and it is still occurring in North America and, more frequently in Western Europe and the developing world. I discuss the epidemiology and major causes of sev...

    journal_title:Early human development

    pub_type: 杂志文章,评审


    authors: Maisels MJ

    更新日期:2009-11-01 00:00:00

  • Surfactant in the perinatal period.

    abstract::Surfactant is now available for general clinical use in infants with RDS. While surfactant is effective, it does not prevent lung disease in many preterm infants because of other aspects of lung immaturity. In experimental models, corticosteroids alter the fetal lung by improving compliances, increasing lung volumes, ...

    journal_title:Early human development

    pub_type: 杂志文章,评审


    authors: Jobe AH

    更新日期:1992-06-01 00:00:00

  • Methods of enteral feeding in preterm infants.

    abstract::Whenever possible, oral feeding is the preferred method in neonatal feeding. However, many premature infants are unable to suck and swallow effectively; in these cases alternative methods of nutrient delivery must be used. We briefly review the different feeding methods used in neonatal units, with particular attentio...

    journal_title:Early human development

    pub_type: 杂志文章,评审


    authors: Maggio L,Costa S,Zecca C,Giordano L

    更新日期:2012-05-01 00:00:00

  • Sports and sportsmen as role models - or otherwise - in the COVID-19 era.

    abstract::As major sport events have been cancelled and postponed in response to COVID-19, the necessity to protect and provide a holistic approach to the professional athlete has never been greater. To do so one must understand the negative consequences for athletes in relation to the cancellation and postponement of such even...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Scerri M,Grech V

    更新日期:2020-11-12 00:00:00

  • Maternal diseases, alcohol consumption and smoking during pregnancy associated with reduction limb defects.

    abstract::To evaluate the association of acute and common chronic diseases, alcohol consumption and smoking during pregnancy with reduction limb defects (RLD) 453 cases of RLD from the Finnish Registry of Congenital Malformations were studied. RLD cases without additional malformations were analyzed separately. Statistical asso...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Aro T

    更新日期:1983-12-01 00:00:00

  • Pre-pregnancy iron reserves, iron supplementation during pregnancy, and birth weight.

    abstract:BACKGROUND:Early iron supplementation in women with sufficient reserves could provoke iron excess resulting in haemoconcentration and low infant birth weight (IBW). AIM:To clarify the influence of early iron supplementation on maternal iron status and the IBW, taking into account pre-pregnancy iron deposits. STUDY DE...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Aranda N,Ribot B,Garcia E,Viteri FE,Arija V

    更新日期:2011-12-01 00:00:00

  • Fetal breathing movements--a comparison of hard copy records produced by M-mode and Doppler ultrasound.

    abstract::To precisely measure the events of the fetal breath cycle it is necessary to have an accurate hard copy record. Two approaches to this have been made using either M-mode or Doppler ultrasound. It was the aim of this paper to compare these methods. Hard copy records of fetal breathing movements were produced by simulta...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Trudinger BJ,Cook CM

    更新日期:1989-12-01 00:00:00

  • Growth in the first four years: III. The effects of maternal factors associated with small-for-dates and large-for-dates pregnancies.

    abstract::Relationships between maternal factors associated with very slow and very fast fetal growth rate, and the postnatal growth patterns within groups of 238 small-for-dates (SFD) and 241 large-for-dates (LFD) children were examined. Within the SFD group significant differences were found in their weight, height, and to a ...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Ounsted M,Moar V,Scott A

    更新日期:1982-12-01 00:00:00

  • A light/dark cycle in the NICU accelerates body weight gain and shortens time to discharge in preterm infants.

    abstract:BACKGROUND:Bright constant light levels in the NICU may have negative effects on the growth and development of preterm infants OBJECTIVE:The aim of this study is to evaluate the benefits of an alternating light/dark cycle in the NICU on weight gain and early discharge from the therapy in premature infants. PATIENTS A...

    journal_title:Early human development

    pub_type: 杂志文章,随机对照试验


    authors: Vásquez-Ruiz S,Maya-Barrios JA,Torres-Narváez P,Vega-Martínez BR,Rojas-Granados A,Escobar C,Angeles-Castellanos M

    更新日期:2014-09-01 00:00:00

  • Aerobic exercise during pregnancy influences infant heart rate variability at one month of age.

    abstract:BACKGROUND:Previously, we reported that regular maternal aerobic exercise during pregnancy was associated with lower fetal heart rate (HR) and higher heart rate variability (HRV) at 36weeks gestation. We now report the effect of maternal exercise on infant HR and HRV in subjects who remained active in the study at the ...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: May LE,Scholtz SA,Suminski R,Gustafson KM

    更新日期:2014-01-01 00:00:00

  • Albumin levels in pregnancy: a hypothesis--decreased levels of albumin are related to increased levels of alpha-fetoprotein.

    abstract::Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Maher JE,Goldenberg RL,Tamura T,Cliver SP,Hoffman HJ,Davis RO,Boots L

    更新日期:1993-10-01 00:00:00

  • Circadian rhythms in preterm infants: a preliminary study.

    abstract::A method has been developed for long-term continuous recordings of several physiological variables in humans, including body movements, core temperature, heart rate and respiratory rate. This method enabled us to study circadian rhythms of body temperature and rest-activity in preterm infants. In 5 out of 9 infants (r...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Mirmiran M,Kok JH,de Kleine MJ,Koppe JG,Overdijk J,Witting W

    更新日期:1990-08-01 00:00:00

  • Care in early pregnancy.

    abstract::This century has seen marked improvement in perinatal outcomes but prematurity remains a problem the world over. To improve these results requires more attention to early pregnancy or even pre-pregnancy care. Control of pre-existing conditions, improved social behavior in nutrition, smoking cessation and other factors...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Work BA

    更新日期:1992-06-01 00:00:00

  • Selecting sex: the effect of preferring sons.

    abstract::Son preference remains common in countries from East Asia through South Asia to the Middle East and North Africa. Where sex selective technology and abortion are readily available, such as in China, South Korea and India, this has led to a marked excess in male births. Worst excesses are seen in parts of rural China w...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Hesketh T

    更新日期:2011-11-01 00:00:00

  • Breast milk retinol concentration in mothers of preterm newborns.

    abstract:BACKGROUND:Preterm newborns have low vitamin A reserves at birth, which increases their risk of morbidity and mortality. In the absence of supplementation, breast milk is the only source of this nutrient for exclusively breastfed infants. AIMS:To assess retinol concentration in preterm milk and the relationship betwee...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Lima MS,da Silva Ribeiro KD,Pires JF,Bezerra DF,Bellot PE,de Oliveira Weigert LP,Dimenstein R

    更新日期:2017-01-01 00:00:00

  • COVID-19: A global and continental overview of the second wave and its (relatively) attenuated case fatality ratio.

    abstract:INTRODUCTION:COVID-19 is pandemic. International travel bans in March 2020 dampened viral spread and resulted in an overnight global economic crisis. As countries ease travel and social distancing restrictions, viral resurgences are expected. This study was carried out in order to delineate the development of a second ...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Grech V,Cuschieri S

    更新日期:2020-10-03 00:00:00

  • Cranial computed tomography in the under twos.

    abstract::One hundred consecutive cranial computed tomographic scans were reviewed in children aged 0-2 years, presenting to the Royal Belfast Hospital for Sick Children. The mean age at scanning was 8.3 months and 73% of the scans were abnormal. The majority of scans were performed electively (78%). The commonest indication fo...

    journal_title:Early human development

    pub_type: 杂志文章


    authors: Hill AE,Hicks EM

    更新日期:1991-08-01 00:00:00