Abstract:
:The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblastic cells in proliferative cell columns and in chorionic villi. We postulate that CRH may have an important role in early placental development and successful pregnancy.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Choy MY,Leung TN,Lau TKdoi
10.1016/j.earlhumdev.2004.04.010keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
77-80issue
1eissn
0378-3782issn
1872-6232pii
S0378-3782(04)00053-2journal_volume
79pub_type
杂志文章abstract::Bronchopulmonary dysplasia (BPD) is one of the most important sequelae of premature birth and the most common form of chronic lung disease of infancy. From a clinical standpoint BPD subjects are characterized by recurrent respiratory symptoms, which are very frequent during the first years of life and, although becomi...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.07.015
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Infants whose mothers had low serum pregnancy-associated plasma protein-A (PAPP-A) in the first trimester were observed to have intrauterine growth retardation. AIM:Suggesting that PAPP-A plays an important role in the availability and activity of insulin-like growth factors (IGFs), which affect growth, we ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.10.005
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To assess the influence of mother-child interaction on children's cognitive development in a group of children prenatally exposed to methadone or buprenorphine. STUDY DESIGN:The study is part of a prospective longitudinal project investigating the development of children born to women in opioid maintenance t...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.08.013
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The osmotic fragility of red blood cells reflects their membrane ability to maintain structural integrity. The osmolality at which the cells lyse is related to their shape, deformability, surface area/volume ratio and intrinsic membrane properties. In cord blood, there may be differences between premature an...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(03)00009-4
更新日期:2003-05-01 00:00:00
abstract::We report a breast-fed preterm infant (31 weeks gestation) who developed nutritional zinc deficiency 13 weeks post delivery. Serial samples of his mothers breast milk from early lactation (2 weeks post delivery) contained very low zinc concentrations, although her serum zinc and sweat zinc concentrations were normal. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90062-3
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Intrauterine growth restriction (IUGR) is a fetal condition characterized by growth-rate reduction. Afflicted fetuses tend to display abnormalities in heart rate. OBJECTIVE:To study the differences in the heart-rate variability of low-risk fetuses and IUGR fetuses during different behavioral states. METHOD...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.07.002
更新日期:2013-10-01 00:00:00
abstract::The prone sleeping position has been identified in world-wide epidemiological studies as a major risk factor for sudden infant death syndrome (SIDS). Public awareness campaigns throughout the western world have led to an over 50% reduction in postneonatal mortality and frequency of SIDS. This reduction in mortality ha...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/s0378-3782(02)00025-7
更新日期:2002-10-01 00:00:00
abstract::Pregnancy is characterized by physiological, endocrine and metabolic adaptations creating a pseudo-diabetogenic state of progressive insulin resistance. These adaptations occur to sustain continuous fetal requirements for nutrients and oxygen. Insulin resistance develops at the level of the skeletal muscle, and matern...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2016.01.008
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The kidney is one organ which presents distinct morphology depending on GA; the classic references for kidney measurements were established several years ago and it is not certain if they are still accurate. AIM:To evaluate the renal maturity using a computer-assisted morphometry in autopsied fetuses within...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.01.013
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2003.08.017
更新日期:2003-12-01 00:00:00
abstract::Doctors are pivotal characters in Star Trek. This paper will review Dr. Julian Bashir, a unique medic who is genetically engineered to superhuman capacities while deliberately designed to have human failings, which he successfully overcomes. His genetic enhancements allow him to excel in whatever he does and although ...
journal_title:Early human development
pub_type: 杂志文章,实务指引
doi:10.1016/j.earlhumdev.2020.104992
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the preschool neurodevelopmental outcome in CDH survivors between 2 and 5 years of age and to identify perinatal and postnatal factors that may be predictive of persistent neurological deficits. METHODS:The study cohort consists of 60 CDH survivors that were enrolled in our prospective, follow-up...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.12.009
更新日期:2013-06-01 00:00:00
abstract::Improvements in perinatal and neonatal management have not only led to a higher survival rate of very low birth weight infants (VLBW; < or = 1,500 g or < 32 weeks gestational age), but also to a better outcome of these children. However the percentage of VLBW children who need special education because of later school...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00056-0
更新日期:2000-01-01 00:00:00
abstract::Adrenocortical response to stress in neonates was assessed by estimating salivary concentrations of cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S). Behavioral responses to stress were also scored clinically, according to the method of Lewis and Thomas [15]. The modulation of these ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(96)01749-5
更新日期:1996-09-20 00:00:00
abstract:OBJECTIVE:Many preterm children show difficulties in attention at (pre)school age. The development of attention capacities of preterm and term toddlers was compared using a longitudinal and multi-method approach at 12, 18 and 24months. METHOD:Attention was measured for 123 preterm (32-36weeks gestation) and 101 term b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.08.015
更新日期:2015-12-01 00:00:00
abstract::Bilirubin-albumin binding was quantitated (peroxidase method) before, during, and after phototherapy in 21 jaundiced infants. Binding was analyzed at two different serum dilutions (1:1.8 and 1:57) to determine whether binding competitors are present during phototherapy. No significant changes in binding were found at ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90099-8
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVES:To determine whether early mortality (first year of life) risks among small for gestational age (SGA) neonates were similar regardless of SGA subtype based on three chronological classifications (term, preterm and post-term). STUDY DESIGN:Retrospective cohort study on all singleton live births in the United...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.05.008
更新日期:2007-02-01 00:00:00
abstract::A method has been developed for long-term continuous recordings of several physiological variables in humans, including body movements, core temperature, heart rate and respiratory rate. This method enabled us to study circadian rhythms of body temperature and rest-activity in preterm infants. In 5 out of 9 infants (r...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90137-8
更新日期:1990-08-01 00:00:00
abstract::28 polygraphic recordings were made in normal infants: 20 in full-term newborns and 8 in 2- to 10-wk-old babies. In full-term newborns sighs and apneas (greater than 5 sec) were significantly more numerous in active (REM) sleep, while startles prevailed in quiet (NREM) sleep. The incidence of all these events diminish...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(78)90051-8
更新日期:1978-04-01 00:00:00
abstract::Eleven healthy fetuses between 36 and 39 weeks of gestation were studied during the active sleep state to examine effects of a 5-s vibratory acoustic stimulus on the baseline fetal heart rate and flow velocity waveform in the fetal internal carotid artery. There was an immediate marked rise in baseline fetal heart rat...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(89)90105-9
更新日期:1989-04-01 00:00:00
abstract::The reactions of heart rate (HR), systolic (sBP) and diastolic (dBP) blood pressure were studied in response to passive head-up tilting (successively to +45 degrees and +90 degrees) in a group of 83 full-term, 1- to 7-day-old newborns who were quiet and awake. A significant mean increase of HR was noted for the whole ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01706-2
更新日期:1996-03-22 00:00:00
abstract::Near infra-red spectroscopy (NIRS) is a comparatively new method for monitoring the oxygenation in blood and tissue in the brain of the fetus and the neonate. Absorption of light in the wavelength range 700-1000 nm through such tissue is measured, which is then used to calculate changes in the concentration of cerebra...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(92)90163-b
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:It remains unclear whether performing amniocentesis to detect intra-amniotic infection is useful for improving neonatal outcomes. AIMS:To determine the efficacy of amniocentesis on the neonatal outcomes in women exhibiting threatened preterm labor and intact membranes. STUDY DESIGN:Retrospective cohort stu...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.03.006
更新日期:2015-05-01 00:00:00
abstract::Fungal-related morbidity and mortality is a major concern for most neonatal intensive care units (NICUs) worldwide. Incidence rates are increasing and might be higher than reported due to the challenges associated with diagnosing fungal infections. As preterm neonates display clinical characteristics that make them pr...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2011.01.013
更新日期:2011-03-01 00:00:00
abstract::The relationship between blood glucose and body physique of 233 (42 hypo-and 191 normologycemic) intrauterine growth-retarded neonates was analyzed using different body measurements and indices of body proportions. Classification by combination of weight and length deficit for fetal age revealed that the disproportion...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(77)90027-5
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decrea...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.01.001
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To compare measurements of the upper arm cross-sectional areas (total arm area, arm muscle area, and arm fat area of healthy neonates) as calculated using anthropometry with the values obtained by ultrasonography. MATERIALS AND METHODS:This study was performed on 60 consecutively born healthy neonates: gesta...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(98)00085-1
更新日期:1999-03-01 00:00:00
abstract::The cephalocaudal progression of jaundice was studied in 136 mature, clinically well newborns. The yellow colour of the skin was measured with the transcutaneous bilirubinometer. Significant positive correlation was found between the yellow colour of the skin in four regions and the plasma bilirubin concentration (for...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90022-b
更新日期:1990-04-01 00:00:00
abstract::Relationships between maternal factors associated with very slow and very fast fetal growth rate, and the postnatal growth patterns within groups of 238 small-for-dates (SFD) and 241 large-for-dates (LFD) children were examined. Within the SFD group significant differences were found in their weight, height, and to a ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90036-6
更新日期:1982-12-01 00:00:00
abstract::The idea of an artificial neural network is introduced in a historical context, and the essential aspect of it, viz., the modifiable synapse, is compared to the aspect of plasticity in the natural nervous system. Based on such an artificial neural network, a model is presented for the way in which (the path along whic...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(93)90045-v
更新日期:1993-09-01 00:00:00