Abstract：
BACKGROUND:Patent ductus arteriosus (PDA) is a frequent problem in preterm infants, and its incidence is inversely correlated with gestational age. The efficacy of medical treatment decreases with decreasing gestational age (GA), and failure rates as well as ductus ligation rates of 40% have been reported in <28 week GA newborns. The aim of this study was to determine whether echocardiographic parameters can predict response to ibuprofen treatment of PDA.
STUDY DESIGN:In a longitudinal study, 29 infants born <28 week GA were screened for a significant PDA (left atrial to aortic root ratio>1.4, anterior cerebral artery resistance index>0.8, and oxygen requirement>35%) at 24-72 h of life and, if a PDA was found, treated with 10-5-5mg/kg ibuprofen intravenously every 24h. Ductal parameters were monitored by serial echocardiography. Infant neurodevelopmental outcomes were assessed at 24 month corrected age.
RESULTS:All 15 infants with significant PDA responded to the ibuprofen loading dose indicated by reduced PDA diameters or increased PDA maximum flow velocities (PDA V(max)), and 7 patients showed an ongoing response resulting in a closed PDA after the 1st cycle (47%). Of the 8 non-responders, 7 received a 2nd cycle with 2 further responders (29%). All non-responders to the 2nd course had a PDA V(max) journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract：:A new protocol for Structured Observation of Motor Performance in Infants, SOMP-I, designed to describe both progress and quality of motor performance, was evaluated concerning its ability to describe and to discriminate between the motor performance observed in different groups of infants. Sixty-eight infants born at...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(95)01678-3
更新日期：1995-11-24 00:00:00
abstract：:Posture and spontaneous motor patterns during the first days of life were studied in ten healthy fullterm infants by direct observation and videorecording. The aim of the study was to provide a description of motor and postural characteristics of normal newborns. The infants were recorded for 1 h on their first and fo...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90020-0
更新日期：1989-02-01 00:00:00
abstract：:Whenever possible, oral feeding is the preferred method in neonatal feeding. However, many premature infants are unable to suck and swallow effectively; in these cases alternative methods of nutrient delivery must be used. We briefly review the different feeding methods used in neonatal units, with particular attentio...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(12)70011-7
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Parent perception of child vulnerability (PPCV) and parent overprotection (POP) are believed to have serious implications for age appropriate cognitive and psychosocial development in very low birth weight preterm children. AIM:With recent concerns about suboptimal developmental outcomes in late-preterm chi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.07.005
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Evaluation of cerebellar morphology and measurement of its biometric parameters such as cerebellar vermis height and transverse cerebellar diameter may assist the neonatologist in monitoring cerebellar growth and development and detect abnormalities resulting from malformations, hemorrhage or ischemic infarc...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.10.001
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Patent ductus arteriosus (PDA) is common in extremely premature infants and associated with increased morbidity and mortality. Medical management of PDA uses either indomethacin or ibuprofen. Despite numerous studies, uncertainty exists as to which drug is safer or more effective; we sought to fill this know...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:Developmental changes in muscle coordination patterns of normal and abnormal general movements (GMs) are described. GMs were studied simultaneously with video-recording and polymyography (polyEMG). GMs of normal full-term infants gradually lose their neonatally slow and 'writhing' character, to be turned into the eleg...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(93)90038-v
更新日期：1993-09-01 00:00:00
abstract：:Data on the postnatal growth patterns of 238 small-for-gestational age (SGA) and 241 large-for-gestational age (LGA) babies are presented. Three proportionality ratios were selected; and their changes in shape, by these indices, during the first 7 years are compared with a random sample of 284 children drawn from the ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90095-2
更新日期：1986-02-01 00:00:00
abstract：:Eleven healthy fetuses between 36 and 39 weeks of gestation were studied during the active sleep state to examine effects of a 5-s vibratory acoustic stimulus on the baseline fetal heart rate and flow velocity waveform in the fetal internal carotid artery. There was an immediate marked rise in baseline fetal heart rat...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90105-9
更新日期：1989-04-01 00:00:00
abstract：:Ultrastructural and immunohistochemical studies were made of the testicular interstitial tissue from eight human fetuses of 15 to 27 weeks gestation. Three cell types developed in mesenchymal cells: Leydig cells and peritubular cells, as already reported, and cells of the mononuclear phagocyte system (MPS), which are ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(89)90070-4
更新日期：1989-09-01 00:00:00
abstract：:The reported energy content of infant formulas will vary, depending upon the method used to calculate or measure the caloric value. Manufacturers' specifications regarding the energy content of milk formulas reflects the 'metabolizable' energy. i.e., the amount of energy which is digested and absorbed by the infant. H...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90124-4
更新日期：1982-07-01 00:00:00
abstract：OBJECTIVE:Many preterm children show difficulties in attention at (pre)school age. The development of attention capacities of preterm and term toddlers was compared using a longitudinal and multi-method approach at 12, 18 and 24months. METHOD:Attention was measured for 123 preterm (32-36weeks gestation) and 101 term b...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2015.08.015
更新日期：2015-12-01 00:00:00
abstract：:In the last two decades the survival of extreme preterm infants and sick newborn infants has improved significantly due to the advances in perinatal medicine. Despite this advance, for some babies, withholding or withdrawal of life sustaining treatment may be the best option in the interest of the baby. An overview of...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.01.002
更新日期：2012-02-01 00:00:00
abstract：:Several studies have described an association between very preterm birth and behavioral and psychiatric outcomes in childhood and adolescence. The exact mechanisms underlying this association are unknown, but impaired neurodevelopment has been proposed as a possible etiological factor. Existing research suggests a sel...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2013.02.002
更新日期：2013-04-01 00:00:00
abstract：:Several guidelines have been created in an attempt to raise the quality of different kinds of studies. These also attempt to ensure that research is reported accurately and transparently. Six such guidelines (CONSORT, MOOSE, PRISMA, SPIRIT, STARD, and STROBE) will be briefly discussed in this paper. The purpose of the...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.05.014
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The second-to-fourth digit ratio (2D:4D) reflects prenatal estrogen and testosterone exposure, and is established in utero. Sex steroids are implicated in development and progression of primary brain tumors. AIMS:To investigate whether there is a link between 2D:4D ratio and primary brain tumors, and age at...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.10.003
更新日期：2016-12-01 00:00:00
abstract：:We measured plasma and erythrocyte vitamin E (VE) and plasma vitamin A (VA) profiles in 48 full-term and 8 preterm pairs of neonates and their mothers at birth and we determined whether there is any relationship between maternal and umbilical cord for the nutrients measured. At the same time, we assessed the influence...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(98)00070-x
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Few studies describe in detail the pregnancy and early development of infants with Prader-Willi syndrome (PWS). However, variations at these early stages may partially account for differences in the later phenotype. A recent paper described an abnormally high number of problems in pregnancy and early infancy...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.08.007
更新日期：2008-05-01 00:00:00
abstract：:To learn if chemoreceptor control of breathing is abnormal in babies whose mothers took narcotics, cocaine, or both drugs during pregnancy, we performed hypoxia and hypercapnia challenges on 28 babies (greater than or equal to 36 weeks gestation). Six babies were exposed to narcotics, six to cocaine, nine to both drug...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(91)90193-7
更新日期：1991-12-01 00:00:00
abstract：:This century has seen marked improvement in perinatal outcomes but prematurity remains a problem the world over. To improve these results requires more attention to early pregnancy or even pre-pregnancy care. Control of pre-existing conditions, improved social behavior in nutrition, smoking cessation and other factors...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(92)90064-n
更新日期：1992-06-01 00:00:00
abstract：:Fourteen infants of 2 months or 6 months of age were video-recorded during polysomnography. Four were normal infants, five had a history of ALTE (apparent life threatening event) and five had repeated and prolonged apnoea during sleep. Two ALTE infants have been recorded at 2 months as well as at 6 months of age. Move...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)90098-1
更新日期：1994-12-16 00:00:00
abstract：:The behavior exhibited by human fathers at their first contact with the young was studied on 15 fathers of full-term infants delivered by cesarean section. The naked infant was presented to the father approximately 15 min after delivery, and photographs were taken every second during the first 7 min of contact. An ord...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90017-3
更新日期：1979-03-01 00:00:00
abstract：BACKGROUND:Cases suggestive of non-acidemia related cerebral palsy (CP) are likely misdiagnosed as acidemia related CP because of the presence of nonreasuring fetal heart rate (FHR) patterns. AIMS:Our purpose was to compare intrapartum FHR patterns between the cases of neurological damage and the cases without disabil...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.10.007
更新日期：2009-04-01 00:00:00
abstract：:Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(13)70005-7
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Controversial results have been reported on the effect of type of feeding on the level of fecal calprotectin in infants. OBJECTIVE:To assess fecal calprotectin levels in breast fed or nonbreast fed healthy infants. DESIGN:A study was conducted to compare fecal calprotectin in infants who were exclusively b...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2014.06.005
更新日期：2014-09-01 00:00:00
abstract：:Psychobiological studies of fetal ontogenesis in non-human species, particularly in laboratory rat, now have much to offer students of human development. Psychobiological approaches are 'ecologically' oriented which, for fetal research, implies consideration of the adaptive significance of behavior within the uterine ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/0378-3782(93)90102-z
更新日期：1993-12-31 00:00:00
abstract：:In the scholarly environment, research findings are disseminated as journal papers which support/dispute extant knowledge or add further to what is already known. The entire manuscript needs to be cited (in-text) and referenced (at the end of article), in order for readers to ascertain the validity of the research cla...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2018.09.012
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:At present, the diagnosis of pulmonary hypoplasia is based on postmortem findings, and there are no clear clinical diagnostic criteria to facilitate its identification and management. AIM:To characterise the respiratory status of pulmonary hypoplasia syndrome (PHS) following preterm rupture of membranes so ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2003.07.002
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Corrected age is typically applied when assessing the development of children born <32 weeks of gestation. There is no consensus as to whether corrected age should be applied when assessing children born late/moderately preterm (LMPT; 32-36 weeks of gestation). AIMS:This study explored the impact of correct...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.01.002
更新日期：2016-03-01 00:00:00
abstract：:In this study the seven postural responses selected by Vojta to evaluate neuromotor development were applied to 68 very low birth weight (VLBW) (greater than 1500 g) infants and to 28 healthy infants of normal birth weight (less than 2500 g). Of the 68 VLBW infants, 41 were small for gestational age and 27 appropriate...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(90)90140-e
更新日期：1990-11-01 00:00:00
