Abstract:
BACKGROUND:Controversial results have been reported on the effect of type of feeding on the level of fecal calprotectin in infants. OBJECTIVE:To assess fecal calprotectin levels in breast fed or nonbreast fed healthy infants. DESIGN:A study was conducted to compare fecal calprotectin in infants who were exclusively breastfed compared to those who were not breastfed in Shanghai, China. Stool samples were collected and analyzed, and the fecal calprotectin concentration was determined using a commercially available enzyme-linked immunosorbent assay. The infant's weight and length were measured. Parents were asked to fill in a brief questionnaire, with questions about several clinical and sociodemographic factors. SUBJECTS:This study included 105 healthy infants aged 0-5 months. RESULTS:Stool samples were obtained from 105 healthy infants (63 boys, 42 girls) with a median age of 2.86 months (range 1-5.88). The median fecal calprotectin concentration was significantly higher in breast fed infants (377μg/g, range 35-937μg/g) than that in nonbreast fed ones (233μg/g, range 37-895μg/g) (p=0.001). A correlation was found that from 0 to 5 months, fecal calprotectin was negatively and significantly associated with age in both two kinds of feeding (breast fed: Spearman's rho -0.346, p=0.010; nonbreast fed: Spearman's rho -0.478, p<0.001). CONCLUSIONS:Our findings show that the kind of feeding influences the fecal calprotectin concentration and breast fed infants have higher levels than nonbreast fed ones in the first months of life. This may represent that human milk influences the gut mucosa by immunomodulating factors.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Li F,Ma J,Geng S,Wang J,Ren F,Sheng Xdoi
10.1016/j.earlhumdev.2014.06.005subject
Has Abstractpub_date
2014-09-01 00:00:00pages
471-5issue
9eissn
0378-3782issn
1872-6232pii
S0378-3782(14)00150-9journal_volume
90pub_type
杂志文章abstract:INTRODUCTION:In neonates with spina bifida aperta (SBA), leg movements by myotomes caudal to the meningomyelocele (MMC) are transiently observed. It is unclear whether these leg movements relate to functional neural conduction through the MMC. For optimal therapeutical intervention, pathophysiological insight in these ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.09.002
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Intrauterine growth restriction (IUGR) is a fetal condition characterized by growth-rate reduction. Afflicted fetuses tend to display abnormalities in heart rate. OBJECTIVE:To study the differences in the heart-rate variability of low-risk fetuses and IUGR fetuses during different behavioral states. METHOD...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2013.07.002
更新日期:2013-10-01 00:00:00
abstract::The reactions of heart rate (HR), systolic (sBP) and diastolic (dBP) blood pressure were studied in response to passive head-up tilting (successively to +45 degrees and +90 degrees) in a group of 83 full-term, 1- to 7-day-old newborns who were quiet and awake. A significant mean increase of HR was noted for the whole ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01706-2
更新日期:1996-03-22 00:00:00
abstract::The world's literature has been scoured to obtain data on 492 examples of the fetal alcohol syndrome (FAS) in the Northern Hemisphere. The seasonally pattern of FAS birth prevalence rates is compared with the seasonality pattern of ethanol intakes to estimate the time-lag between them and hence the timing of ethanol d...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(83)90065-8
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Hospitalized infants requiring cardiopulmonary resuscitation (CPR) represent a high-risk group. Recent data on risk factors for mortality following CPR in this population are lacking. AIMS:We hypothesized that infant demographic characteristics, diagnoses, and levels of cardiopulmonary support at the time o...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.03.015
更新日期:2016-10-01 00:00:00
abstract::Magnetic Resonance Imaging is becoming more widely available and increasingly important for imaging the neonatal brain. In newborn infants it poses challenges regarding patient preparation, safety, optimal timing, and sequence optimization. These issues are addressed in this paper and indications for performing neonat...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::Vascular tumours (haemangiomas and malformations) are common tumours of infancy and childhood. They represent a group of mostly benign conditions, which present early, can grow rapidly and be symptomatic or disfiguring. There are various management options, with different cosmetic and functional outcomes. Haemangiomas...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.08.017
更新日期:2010-10-01 00:00:00
abstract::The reported energy content of infant formulas will vary, depending upon the method used to calculate or measure the caloric value. Manufacturers' specifications regarding the energy content of milk formulas reflects the 'metabolizable' energy. i.e., the amount of energy which is digested and absorbed by the infant. H...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(82)90124-4
更新日期:1982-07-01 00:00:00
abstract::Surfactant is now available for general clinical use in infants with RDS. While surfactant is effective, it does not prevent lung disease in many preterm infants because of other aspects of lung immaturity. In experimental models, corticosteroids alter the fetal lung by improving compliances, increasing lung volumes, ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(92)90058-o
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS:Eighty-one preterm infants b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2017.12.008
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Using pure oxygen (PO) in neonatal resuscitation increases oxidative stress and mortality in full-term hypoxic infants. International neonatal resuscitation guidelines recommend air or blended oxygen for resuscitation regardless of gestational age but this requires education and equipment that may not be glo...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.01.005
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Children born preterm are at risk of visuospatial attention orienting and processing dysfunctions, which can be quantified early in life using visually-guided eye movement responses. AIMS:To identify the prevalence and perinatal risk factors for visuospatial attention orienting and processing dysfunctions i...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.01.015
更新日期:2019-03-01 00:00:00
abstract::The possibility of assembling this series of Best Practice Guidelines papers pertaining to WASP (Write a Scientific Paper) arose from the international WASP course, and the realisation that the Statistics at Square One papers initially published in the British Medical Journal in the 1970s, dealing with medical statist...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.05.012
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The requirement of essential fatty acids (EFA) for the development of the brain is well documented. OBJECTIVE:To investigate the early neurological development at term and 44 weeks gestational age in preterm infants in relation to EFA concentrations in breast milk and in infants' and mothers' plasma phospho...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.05.017
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Among preterm infants, high concentrations of inflammatory mediators in cerebrospinal fluid (CSF) are associated with poor outcome. Previous studies have not indicated whether CSF concentrations of inflammatory mediators are associated with important confounders such as gestational age. AIMS:To examine asso...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2008.10.011
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The sudden infant death syndrome (SIDS) is still the main cause of postneonatal infant death and its cause is still unknown. Recently, the medullary serotonergic network deficiency theory has been proposed and an association between SIDS and neuronal plasticity has also been suggested. The growth-associated ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2003.08.017
更新日期:2003-12-01 00:00:00
abstract:UNLABELLED:The aim of the study was to determine the effect of a low oral dose of erythromycin on whole gastrointestinal transit time [WGTT]. Erythromycin [EM] [1.5 mg/kg, 6 hourly] or placebo was given first over 7 days in a double blind randomized crossover study of 21 preterm infants with feed intolerance. Median [r...
journal_title:Early human development
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-3782(01)00191-8
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:It remains unclear whether performing amniocentesis to detect intra-amniotic infection is useful for improving neonatal outcomes. AIMS:To determine the efficacy of amniocentesis on the neonatal outcomes in women exhibiting threatened preterm labor and intact membranes. STUDY DESIGN:Retrospective cohort stu...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.03.006
更新日期:2015-05-01 00:00:00
abstract:AIM:The effects of intestinal bifidobacteria on the development of immunity in early life were explored. METHODS:Neonatal SD rats born and housed under strict barrier systems were fed from birth with sufficient antibiotics (bifidobacteria minimisation group) or supplemented daily with 1x10(10) colony-forming units of ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2010.01.002
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Prior studies have shown that children with congenital hearing loss have increased rates of behavior disorders. Child hearing loss has also been reported to be associated with increased maternal stress. Little is known about the behavior or the predictors of behavioral outcomes of children with hearing loss ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.06.006
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:A reliable and valid assessing tool to detect the problem before the child becomes deviant is very important. AIM:This study aimed to further test the reliability and validity of developmental screening instrument for follow-up of thirty-six months children in Taiwan. Also, the stability and changes in the ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2009.12.004
更新日期:2010-01-01 00:00:00
abstract::Newborn infants fulfil some criteria of being conscious i.e. being aware of the body, the self and the world. They are able to differentiate between self and nonself touch, express emotions and show signs of shared feelings. They process sensory impressions including pain at a cortical level. They remember rhythmic so...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2009.08.017
更新日期:2009-10-01 00:00:00
abstract::Prevention of extra-uterine growth retardation is of extreme importance, as the achievement of adequate growth has been associated with a favorable neurodevelopmental outcome through childhood. In addition, as disturbances in growth that take place early in life may affect adult health, a full understanding of the gro...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2013.08.004
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND AIM:To investigate whether neonates with prenatally detected congenital heart defects (CHD) demonstrate cerebral abnormalities on early preoperative cranial ultrasound (CUS), compared to healthy neonates, and to measure brain structures to assess brain growth and development in both groups. STUDY DESIGN...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105097
更新日期:2020-09-01 00:00:00
abstract::The effect of type-I diabetes on the quality of general movements (GMs) was studied longitudinally in 12 human fetuses. GMs were analysed at two-weekly intervals from 16 weeks until delivery. A pregnancy optimality-score and a diabetes optimality-score were used to cover the course of the pregnancy and delivery and th...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(97)00089-3
更新日期:1997-11-24 00:00:00
abstract::The study set out to document child care practices in as many different countries and cultures as possible with the aim of providing baseline child care data and stimulating new hypotheses to explain persisting differences in sudden infant death syndrome (SIDS) rates between countries. The protocol, piloted in four co...
journal_title:Early human development
pub_type: 杂志文章,多中心研究
doi:10.1016/s0378-3782(99)00021-3
更新日期:1999-06-01 00:00:00
abstract::The Golgi-Cox method was used to study the maturation of the large pyramidal cells of the Vth cortical layer in three groups of adult rats: one subjected to undernutrition during the first month of life, another throughout the first 2 mth of life, and the last one during gestation and the suckling period. The main alt...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(86)90186-6
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that RhD positive heterozygotes express better health status than RhD positive homozygotes and especially RhD negative subjects. This also applies to pregnant women. According to the Trivers-Willard hypothesis, women in better physical condition should have more sons. AIM:To test th...
journal_title:Early human development
pub_type: 杂志文章,实务指引
doi:10.1016/j.earlhumdev.2019.104864
更新日期:2020-01-01 00:00:00
abstract::There is increasing evidence that sleep plays a major role in the development of neural pathways in the neonatal brain. Several studies have suggested evidence-based approaches to improve sleep for infants admitted to the neonatal intensive care unit (NICU); however, in many neonatal centers very few of these strategi...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2017.07.002
更新日期:2017-10-01 00:00:00
abstract::Among 7 subjects with hyperemesis gravidarum (HG), we found gabapentin therapy to be associated with mean reductions in nausea and emesis from Baseline to Days 12-14 of 80% and 94%, respectively. There have been 2 congenital defects among 7 exposed infants. Gabapentin may be effective in the treatment of HG. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2009.11.003
更新日期:2010-01-01 00:00:00