Abstract:
:Whether preeclampsia affects the fetal hematologic system still remains a controversial issue. The purpose of this series was to examine the hypothesis that preeclampsia may or may not cause adverse effects on fetal hemogram, including erythrocytes, leukocytes, and platelets. In addition, no one, to date, has reported the effect on red cell distribution width (RDW) of fetal cord blood by preeclampsia. Therefore this series also tested the hypothesis that preeclampsia may induce elevation of RDW in fetal cord blood. From August 1, 1989 to July 31 1990, we prospectively collected cord blood samples at parturition from 21 preeclamptic pregnancies and 366 uncomplicated controls and measured their complete blood counts by computerized blood autoanalyzer. The results of the comparison with red blood cells showed significant erythrocythemia (P < 0.05), increased hematocrit (P < 0.05), elevated hemoglobin (P < 0.05), and marked anisocytosis (as reflected by RDW, P < 0.0001) in preeclamptic pregnancies than in controls. Though no significant differences were demonstrated in the white cell counts, severe thrombocytopenia (P < 0.001) was observed in the preeclamptic group than in controls. We concluded that preeclampsia may cause significant normocytic, normochromic erythrocythemia, marked anisocytosis and severe thrombocytopenia in newborns, which deserved the attention of obstetricians and neonatologists. Further studies are warranted to elucidate the underlying pathophysiological mechanisms.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Huang SC,Chang FMdoi
10.1016/0378-3782(94)90150-3subject
Has Abstractpub_date
1994-05-01 00:00:00pages
91-8issue
2eissn
0378-3782issn
1872-6232pii
0378-3782(94)90150-3journal_volume
37pub_type
杂志文章abstract::The biochemical, dermatological and neurological motor disorders of biotinidase deficiency (multiple carboxylase deficiency) show a dramatic response to pharmacological doses of biotin. This condition is characterised by the accumulation of biocytin and depletion of biotin. Neuromuscular function returns to normal wit...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90086-6
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:The second-to-fourth digit ratio (2D:4D) reflects prenatal estrogen and testosterone exposure, and is established in utero. Sex steroids are implicated in development and progression of primary brain tumors. AIMS:To investigate whether there is a link between 2D:4D ratio and primary brain tumors, and age at...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.10.003
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Cognitive, behavioral, and learning problems are evident in extremely preterm/extremely low birth weight (EPT/ELBW, <28 weeks gestational age or <1000 g) children by early school age. However, we know little about how they function within the classroom once they start school. AIMS:To determine how EPT/ELBW ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.09.011
更新日期:2014-12-01 00:00:00
abstract::White matter injury and abnormal maturation are thought to be major contributors to the neurodevelopmental disabilities observed in children and adolescents who were born preterm. Early detection of abnormal white matter maturation is important in the design of preventive, protective, and rehabilitative strategies for...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2008.09.004
更新日期:2008-12-01 00:00:00
abstract::The aim of the study was to evaluate potential changes of cerebral blood volume (CBV) related to arousals in preterm infants. As arousals are known to change different physiological parameters, it was postulated that this could also hold true for CBV. Polygraphic recordings were performed in 38 preterm infants (18 fem...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2006.05.019
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Controversial results have been reported on the effect of type of feeding on the level of fecal calprotectin in infants. OBJECTIVE:To assess fecal calprotectin levels in breast fed or nonbreast fed healthy infants. DESIGN:A study was conducted to compare fecal calprotectin in infants who were exclusively b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.06.005
更新日期:2014-09-01 00:00:00
abstract::Newborn infants in critical conditions require a permanent intra-venous line to allow for the administration of fluids, parenteral nutrition and drugs. The use of central venous catheters, however, is associated with an increased risk of infections, leading to prolongation of length of stay and higher hospitalization ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/S0378-3782(14)70017-9
更新日期:2014-03-01 00:00:00
abstract::To investigate the influence of prematurity and postnatal age on the maturation of the autonomic nervous system function, we analysed heart-rate and heart-rate variability in twelve prematurely born infants (< 37 weeks gestational age) reaching the conceptional age of 37-41 weeks. These neonates were compared with six...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(93)90011-i
更新日期:1993-03-01 00:00:00
abstract::Spectral analysis was performed on ventilation and instantaneous heart rate data recorded in 15 term infants during quiet sleep in the first week after delivery, and in 11 of these infants during active sleep. There was a close relation between the main peaks of the ventilation spectra and the corresponding histograms...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(89)90050-9
更新日期:1989-11-01 00:00:00
abstract:AIMS:1. To determine the survival and morbidity of infants at discharge with a birthweight of less than 1500 g in the geographically defined population of East Anglia. 2. To demonstrate a cost-effective method of regional data collection. 3. To determine whether there were any changes in the demand for neonatal care. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2005.10.019
更新日期:2006-02-01 00:00:00
abstract::Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.10.008
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Small size at birth may be associated with impaired cognitive ability later in life. The aim of this study was to examine the effect of being born small for gestational age (SGA), with or without intrauterine growth restriction (IUGR) on cognitive ability in late adolescence. STUDY DESIGN:A follow-up study ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.08.014
更新日期:2015-12-01 00:00:00
abstract::The aim of this study was to determine whether corticotropin-releasing hormone (CRH) regulates human trophoblast cell growth. The results showed that exogenous CRH significantly stimulated human trophoblast proliferation in first-trimester primary cultures. In vivo, CRH was strongly immunolocalised to cytotrophoblasti...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2004.04.010
更新日期:2004-08-01 00:00:00
abstract::Surfactant is now available for general clinical use in infants with RDS. While surfactant is effective, it does not prevent lung disease in many preterm infants because of other aspects of lung immaturity. In experimental models, corticosteroids alter the fetal lung by improving compliances, increasing lung volumes, ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/0378-3782(92)90058-o
更新日期:1992-06-01 00:00:00
abstract::This study documents the longitudinal development of head control in 104 infants born at 25-33 weeks gestation. Protective side turning of the head was found to have a developmental sequence of reducing spinal extension. In the 93 infants with normal motor outcome, individual differences in the rate of development cor...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90074-x
更新日期:1985-09-01 00:00:00
abstract:AIM:This study examined the rates of follow-up for a cohort of extremely preterm (EP -<28weeks gestation) and/or extremely low birthweight (ELBW -<1000g) children at two years with related perinatal and geographical factors. The secondary aim was to determine the rates of developmental delay and disability. METHODS:A ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2015.09.012
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To compare paired antepartum fetal/maternal COHb ratios in whole blood from control and alloimmunized pregnancies and to examine the relationships between fetal and maternal COHb. METHODS:COHb levels were measured in paired fetal and maternal blood samples obtained at cordocentesis in 47 control and 16 Rh-al...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(00)00079-7
更新日期:2000-06-01 00:00:00
abstract:UNLABELLED:During the previous two decades smoking among pregnant women in the developed world declined by about 60-75%. Nevertheless, prenatal smoking remains a common habit and accounts for a significant proportion of fetal morbidity and mortality through both a direct (fetal) and an indirect (placental) effect. The ...
journal_title:Early human development
pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2007.08.002
更新日期:2007-11-01 00:00:00
abstract::In this study the seven postural responses selected by Vojta to evaluate neuromotor development were applied to 68 very low birth weight (VLBW) (greater than 1500 g) infants and to 28 healthy infants of normal birth weight (less than 2500 g). Of the 68 VLBW infants, 41 were small for gestational age and 27 appropriate...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(90)90140-e
更新日期:1990-11-01 00:00:00
abstract::Increasing public awareness of the prone sleeping position, maternal smoking and overheating as potentially avoidable risk factors for the sudden infant death syndrome (SIDS) has been accompanied by a dramatic reduction in mortality. The results of two population based studies of SIDS in Avon are compared; the first o...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(94)90208-9
更新日期:1994-09-15 00:00:00
abstract::The anatomical findings of sirenomelia in a 12-weeks aborted embryo are reported. The occurrence of sirenomelia in material from spontaneous abortions is discussed. ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(87)90080-6
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:To 1) define predictors of parent presence, any holding, holding in arms, and skin-to-skin care in the NICU and 2) investigate the relationships between parent participation and a) early neurobehavior and b) developmental outcomes at age 4 to 5years among preterm infants. METHODS:Eighty-one preterm infants b...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2017.12.008
更新日期:2018-02-01 00:00:00
abstract::It is convenient to calculate milk energy from the creamatocrit but in order to assess the accuracy with which energy content can be predicted in this way, the creamatocrit, the percentage of carbon, and the calorie value of milk were determined in 11 samples of pooled pasteurised human milk. The calculated milk energ...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(85)90121-5
更新日期:1985-05-01 00:00:00
abstract::Here presented are the different human fetal larynx functions. Analysis and observation of the organ show at least three behavioural patterns: swallowing, respiratory and phonetic. The respiratory function coincides with a blood aspiration through the venosus duct (phenomenon measured by pulsed Doppler) which increase...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/0378-3782(95)01721-6
更新日期:1996-07-05 00:00:00
abstract::Improvements in perinatal and neonatal management have not only led to a higher survival rate of very low birth weight infants (VLBW; < or = 1,500 g or < 32 weeks gestational age), but also to a better outcome of these children. However the percentage of VLBW children who need special education because of later school...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(99)00056-0
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Preterm infants have a high risk of cranial deformity resulting from external pressures. Such deformity is associated with delayed neurodevelopment. AIMS:We aimed to clarify the effects of continuous use of positioning pillows on cranial deformity and neurodevelopment in preterm infants. METHODS:This prosp...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105137
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Even though the biological norm in humans is frequent on demand breastfeeding, sparse feeding intervals have become the cultural norm in most Western countries due to a history of on schedule breastfeeding. This discrepancy between the biological basis and the culturally driven practice continues to interfer...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2020.105242
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Testosterone (T) is taken or prescribed to enhance appearance, increase athletic performance and libido and to treat hypogonadism. Digit ratio (2D:4D) is thought to be a negative correlate of prenatal T. Here we consider the relationship between 2D:4D and T supplementation. AIMS:Our sample was taken from th...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2019.104843
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the preschool neurodevelopmental outcome in CDH survivors between 2 and 5 years of age and to identify perinatal and postnatal factors that may be predictive of persistent neurological deficits. METHODS:The study cohort consists of 60 CDH survivors that were enrolled in our prospective, follow-up...
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.12.009
更新日期:2013-06-01 00:00:00
abstract::Fetal bladder volume and hourly fetal urine production (HFUPR) is calculated on the assumption that the fetal bladder is ellipsoid in shape. A recent validation study demonstrated a progressive overestimation at increasing bladder volumes. This may be due to changes in shape of the fetal bladder at increasing volumes....
journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/s0378-3782(97)00049-2
更新日期:1998-02-27 00:00:00