Abstract：
:ROP remains a major cause of childhood blindness worldwide. The smallest, sickest infants develop the most severe forms of zone 1 ROP. Such eyes may not be successfully treated by near confluent laser to the avascular retina (current standard of care). With an understanding of ROP pathogenesis, vascular endothelial growth factor inhibitors (anti-VEGF) are being given only when VEGF is elevated in retina and vitreous. Careful screening allows proper timing of administration. Ideal dose (perhaps different for mild and severe cases) and drug (interrupting only pathologic neovascularization and not normal angiogenesis) remain unproven. The author discusses controversial use of anti-VEGF with documented efficacy, observed local complications, and potential systemic toxicities (none observed in six years) to allow retention of vision for severe zone 1 ROP. The benefits have been demonstrated, however, local and systemic risks in these developing premature infants must be carefully studied (both short and long term).
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Mintz-Hittner HAdoi
10.1016/j.earlhumdev.2012.09.019subject
Has Abstractpub_date
2012-12-01 00:00:00pages
937-41issue
12eissn
0378-3782issn
1872-6232pii
S0378-3782(12)00241-1journal_volume
88pub_type
杂志文章abstract：OBJECTIVE:To compare paired antepartum fetal/maternal COHb ratios in whole blood from control and alloimmunized pregnancies and to examine the relationships between fetal and maternal COHb. METHODS:COHb levels were measured in paired fetal and maternal blood samples obtained at cordocentesis in 47 control and 16 Rh-al...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00079-7
更新日期：2000-06-01 00:00:00
abstract：:Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life. Gastro-oesophageal reflux may be a primary gastro-intestinal motility disorder, but it may also be secondary to other conditions such as cow's milk protein allergy. Objective diagnosis can be ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.10.011
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Pregnancy and delivery are complex processes, and isolated obstetric complications rare and often accompanied or followed by a number of others. AIMS:To study the relationship between the overall obstetric situation (as opposed to single obstetric risk factors) and emotional and substance use disorders in y...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2004.04.016
更新日期：2004-11-01 00:00:00
abstract：:The premature birth of a child and admission to the neonatal intensive care unit (NICU) is a distressing experience for parents, and has been associated with symptoms of depression, anxiety and post-traumatic stress. Supporting parents in the NICU after preterm birth is critical not only for their own mental health, b...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2019.104838
更新日期：2019-12-01 00:00:00
abstract：:Cardiorespiratory interactions in healthy full term newborns were investigated. Spectral analysis was used on heart rate and breathing data from 22 neonates 2-5 days old to reveal coincident frequencies in the breathing and heart rate variability (HRV) spectra, thus identifying respiratory sinus arrhythmia (RSA). The ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(93)90197-3
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To identify obstetric risk factors and to elucidate the effect of prolonged rupture of the membranes on the development of cystic periventricular leukomalacia (PVL) in preterm infants. METHODS:A retrospective case-control study of 95 preterm infants with the diagnosis of PVL and 245 healthy controls matched ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.07.007
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To assess the influence of mother-child interaction on children's cognitive development in a group of children prenatally exposed to methadone or buprenorphine. STUDY DESIGN:The study is part of a prospective longitudinal project investigating the development of children born to women in opioid maintenance t...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2016.08.013
更新日期：2016-10-01 00:00:00
abstract：:Twenty-four term infants with disproportionate intrauterine growth retardation (SGA group) and 24 normally grown term infants matched for age, sex, birth rank and social class were followed from birth until 7 years of age. Both groups were free from perinatal complications and chronic diseases. The children in the SGA...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(88)90038-2
更新日期：1988-11-01 00:00:00
abstract：:Several guidelines have been created in an attempt to raise the quality of different kinds of studies. These also attempt to ensure that research is reported accurately and transparently. Six such guidelines (CONSORT, MOOSE, PRISMA, SPIRIT, STARD, and STROBE) will be briefly discussed in this paper. The purpose of the...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.05.014
更新日期：2019-07-01 00:00:00
abstract：:The objectives of this study were (1) to detect vasoactive intestinal polypeptide in fetal blood obtained by cordocentesis (2) to examine possible changes in growth retarded fetuses and to establish relationships between its levels and fetal blood acid-base status as well as fetal haemodynamics as assessed by Doppler ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(94)01610-2
更新日期：1995-03-17 00:00:00
abstract：:Fetal ventricular outflow tract obstruction (OTO) is congenital heart disease with significant potential for progression before birth as a consequence of the unique nature of the fetal circulation. The pattern of evolution depends upon the timing of development, severity of obstruction and the influence of the OTO on ...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2012.02.005
更新日期：2012-05-01 00:00:00
abstract：:The validity of the Wigglesworth experimental model to produce newborn rats that are small for gestational age by ligation of one of both uterine vessels was confirmed. Newborn rats from the opposite horns are used as controls in the classical model. It is concluded from this study that newborns from sham-operated dam...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(79)90038-0
更新日期：1979-09-01 00:00:00
abstract：:This study documents the longitudinal development of head control in 104 infants born at 25-33 weeks gestation. Protective side turning of the head was found to have a developmental sequence of reducing spinal extension. In the 93 infants with normal motor outcome, individual differences in the rate of development cor...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(85)90074-x
更新日期：1985-09-01 00:00:00
abstract：:Forty-four prenatally depressed women were randomly assigned to peer support or interpersonal psychotherapy groups at 22 weeks gestation. The peer support group participated in a 20-minute group session once per week for 12 weeks, and the interpersonal psychotherapy group met for one hour per week for 12 weeks. Assess...
journal_title：Early human development
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.earlhumdev.2013.04.006
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the newborn transient evoked otoacoustic emission (TEOAE) hearing screening tests of infants later diagnosed with the sudden infant death syndrome (SIDS). STUDY DESIGN:In a case-controlled study, the newborn TEOAE hearing screens of 31 infants who subsequently died of SIDS were retrospectively co...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2007.06.001
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Mothers have been shown to have higher morning cortisol on days they go to work compared to non-workdays; however, it is unknown how maternal workday associates with child morning cortisol or the attunement of mother-child morning cortisol. AIMS:This study examined the presence and stability of morning cort...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2013.11.007
更新日期：2014-01-01 00:00:00
abstract：:This study examined the risk factors for respiratory distress syndrome (RDS) in preterm infants from pregnancies complicated by placenta previa. Forty preterm infants born to mothers with placenta previa between January 1989 and December 1995 in a medical center were enrolled. Each of these patients was matched in ges...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(00)00121-3
更新日期：2001-01-01 00:00:00
abstract：:The potential use of a piglet as a model for investigation of brain blood flow was evaluated by assessing the presence of autoregulation in 11 spontaneously breathing newborn piglets. Blood pressure was altered by phlebotomy. When the mean arterial blood pressure was greater than 50 mm Hg, no significant change in bra...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90063-9
更新日期：1982-01-01 00:00:00
abstract：:Maturation of spontaneous fetal body and breathing movements of 24- to 33-week-old fetuses in 168 pregnancies threatening to deliver prematurely were examined on the basis of newborn outcome (premature compromised, premature healthy, term healthy). Maturation of fetuses in 60 low-risk pregnancies delivering as healthy...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(99)00007-9
更新日期：1999-05-01 00:00:00
abstract：:Urinary epidermal growth factor (EGF) excretion was studied serially in 36 newborn infants, from 26 to 40 weeks gestation, from birth to three months of age. All infants excreted EGF from birth. Excretion was significantly higher in term infants than in preterm infants at birth; in term infants excretion rose steadily...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(86)90190-8
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:Improved neonatal survival data have been reported following early preterm prelabour rupture of membranes (PPROM) prior to 25 weeks gestation with a prolonged latency to delivery and persistent oligohydramnios. However, data regarding long-term respiratory and neurological morbidity are lacking. AIMS:To eva...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2012.01.012
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Antenatal depression is associated with adverse social-emotional and behavioural outcomes during childhood but there has been little investigation of the impact on infant neurodevelopment during the first postnatal year. AIMS:The aim of this study was to assess the impact of depression during pregnancy on i...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2019.05.021
更新日期：2019-07-01 00:00:00
abstract：:The transitional circulation of the preterm infant differs significantly from the term infant. The preterm infant is uniquely at risk of hypotension and low systemic blood flow states due to failure or delay in the normal transitional circulation processes. The maintenance of normal tissue oxygenation requires mainten...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2005.03.006
更新日期：2005-05-01 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease wi...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/0378-3782(82)90007-x
更新日期：1982-10-01 00:00:00
abstract：:The purpose of this study was to investigate prostanoid synthesis in different segments of the umbilicoplacental vascular tree and its relationship to impaired maternal glucose tolerance. Segments from the umbilical artery and vein, allantochorionic artery branches, and the cotyledon artery from 21 women with diabetes...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3732(97)00036-2
更新日期：1998-01-09 00:00:00
abstract：:There is increasing evidence that sleep plays a major role in the development of neural pathways in the neonatal brain. Several studies have suggested evidence-based approaches to improve sleep for infants admitted to the neonatal intensive care unit (NICU); however, in many neonatal centers very few of these strategi...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/j.earlhumdev.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:Intrauterine growth restriction (IUGR) is associated with altered lung development in human and rat. The transcription factor PPARγ, is thought to contribute to lung development. PPARγ is activated by docosahexanoic acid (DHA). One contribution of PPARγ to lung development may be its direct regulation of chromatin mod...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2010.08.026
更新日期：2010-12-01 00:00:00
abstract：AIM:To determine whether maternal state and trait anxiety levels affect fetal movements or fetal heart rate (FHR) in the third trimester. SUBJECTS:Forty-one healthy pregnant nulliparous women not on medication and with a singleton pregnancy. STUDY DESIGN:Maternal anxiety was assessed using the Spielberger State- Trai...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/s0378-3782(01)00256-0
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVE:To establish longitudinal reference ranges for the fetal superior mesenteric artery (SMA) flow velocity and pulsatility index (PI(SMA)). Also to examine the hemodynamic relationship to venous liver perfusion and umbilical flow distribution in the liver, to other splanchnic arteries, and more generally to the ...
journal_title：Early human development
pub_type： 杂志文章
doi：10.1016/j.earlhumdev.2008.09.412
更新日期：2009-04-01 00:00:00
abstract：:Pulse oximetry screening is a highly specific, moderately sensitive test for detecting critical congenital heart defects (CCHDs) that meets the criteria for universal screening. The possibility of using pulse oximetry as a screening test was first investigated over 10 years ago and since then data from more than 370,0...
journal_title：Early human development
pub_type： 杂志文章,评审
doi：10.1016/S0378-3782(14)50006-0
更新日期：2014-09-01 00:00:00
