Abstract：
OBJECTIVE:To compare paired antepartum fetal/maternal COHb ratios in whole blood from control and alloimmunized pregnancies and to examine the relationships between fetal and maternal COHb. METHODS:COHb levels were measured in paired fetal and maternal blood samples obtained at cordocentesis in 47 control and 16 Rh-alloimmunized pregnancies. COHb was determined by gas chromatography. Results were analyzed by t-test, regression and analysis of covariance. RESULTS:Although fetal/maternal COHb ratios for control and alloimmunized pregnancies were not statistically significantly different, i.e. 1. 11+/-0.04 and 1.26+/-0.09, respectively (P=0.09), fetal COHb levels were higher in Rh-alloimmunized fetuses (P=0.0002). Fetal COHb levels were also higher than paired maternal levels among the alloimmunized group (P=0.011), but not among the control group (1. 04+/-0.04, P=ns). In univariate regression analysis, fetal and maternal COHb levels were significantly correlated with one another in both control (r=0.52, P=0.0002) and alloimmunized pregnancy groups (r=0.52, P=0.05). Comparison of the slopes of the fetal versus maternal COHb plots for the two groups showed a significant difference (P=0.02), with the alloimmunized group having the steeper slope. CONCLUSION:Differences in the antepartum fetal-maternal COHb relationships in control and alloimmunized groups likely reflect increased endogenous CO production among alloimmunized fetuses as a result of pathologic hemolysis.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Hayde M,Pollak A,Bernaschek G,Weiner CP,Vreman HJ,Stevenson DK,Widness JAdoi
10.1016/s0378-3782(00)00079-7keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
205-12issue
3eissn
0378-3782issn
1872-6232pii
S0378378200000797journal_volume
58pub_type
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journal_title：Early human development
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2001-11-01 00:00:00
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pub_type： 杂志文章
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