当前位置： SCI文献检索 > EARLY HUMAN DEVELOPMENT期刊下所有文献 > Zinc and copper requirements in preterm infants: an examination of the current literature.

Zinc and copper requirements in preterm infants: an examination of the current literature.

Abstract：

BACKGROUND:Zinc and copper are essential for preterm infants, but recommended requirements from different groups vary widely. Recommended zinc intakes have steadily increased over the years. Although this would be expected to impair copper absorption, recommended copper intakes have not risen in parallel. OBJECTIVES:To systematically review the literature on zinc and copper retention in preterm infants; to examine the effect on zinc intake on copper retention; and to estimate the zinc and copper intakes required to meet the levels of zinc and copper retention required for normal growth. DESIGN:Studies reporting zinc and/or copper retention in preterm infants (<36 weeks of gestation) during the first 120 days of life were identified using PubMed. Only studies reporting net retention were included. RESULTS:Fourteen studies on zinc retention reporting data on 45 different groups were identified. Eleven studies (32 groups) were identified reporting copper retention. Zinc retention was significantly higher at higher zinc intakes, and higher in formula-based diets than in human milk based diets. Zinc intakes of between 1.8-2.4 mg/kg/d (from formula based diets) and 2.3-2.4 mg/kg/d (from human-milk based diets) were required to achieve adequate zinc retention. Copper retention was significantly positively correlated with copper intake and significantly negatively correlated with zinc intake. At the zinc intakes suggested previously (1.8-2.4, 2.3-2.4 mg/kg/d), copper intakes of between 200 and 250 mcg/kg/d are required to ensure adequate copper retention. CONCLUSIONS:Our results support the higher zinc intakes recommended in recent guidelines. However, they suggest that recommended copper intakes have not kept pace with increasing zinc intakes, and that preterm infants may need higher copper intakes than currently recommended.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Griffin IJ,Domellöf M,Bhatia J,Anderson DM,Kler N

doi

10.1016/j.earlhumdev.2013.08.001

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

S29-34

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(13)00190-4

journal_volume

89 Suppl 2

pub_type

杂志文章,评审

在线工具

Zinc and copper requirements in preterm infants: an examination of the current literature.